The impact of hepatitis A virus infection on hepatitis C virus infection: a competitive exclusion hypothesis.

Abstract:

:We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show that the inclusion of the immune system explains both the elimination of one virus and the co-existence of both infections for a certain range of parameters. We discuss the potential clinical implications of our findings.

journal_name

Bull Math Biol

authors

Amaku M,Coutinho FA,Chaib E,Massad E

doi

10.1007/s11538-012-9795-0

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

82-93

issue

1

eissn

0092-8240

issn

1522-9602

journal_volume

75

pub_type

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