解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In developmental biology as well as in other biological systems, emerging structure and organization can be captured using time-series data of protein locations. In analyzing this time-dependent data, it is a common challenge not only to determine whether topological features emerge, but also to identify the timing of...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00847-3
更新日期:2021-01-16 00:00:00
abstract::We explore the dynamics of invasive weeds by partial differential equation (PDE) modelling and applying dynamical system and phase portrait techniques. We begin by applying the method of characteristics to a preexisting PDE model of the spreading of T. fluminensis, an invasive weed which has been responsible for nativ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00825-9
更新日期:2021-01-07 00:00:00
abstract::Mechanical cell competition is important during tissue development, cancer invasion, and tissue ageing. Heterogeneity plays a key role in practical applications since cancer cells can have different cell stiffness and different proliferation rates than normal cells. To study this phenomenon, we propose a one-dimension...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00807-x
更新日期:2020-09-26 00:00:00
abstract::We extend a spatially non-local cross-diffusion model of aggregation between multiple species with directed motion toward resource gradients to include many species and more general kinds of dispersal. We first consider diffusive instabilities, determining that for directed motion along fecundity gradients, the model ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00786-z
更新日期:2020-08-11 00:00:00
abstract::We consider a minimalist model for the Sterile Insect Technique (SIT), assuming that residual fertility can occur in the sterile male population. Taking into account that we are able to get regular measurements from the biological system along the control duration, such as the size of the wild insect population, we st...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00790-3
更新日期:2020-08-09 00:00:00
abstract::Studies have been done using networks to represent the spread of infectious diseases in populations. For diseases with exposed individuals corresponding to a latent period, an SEIR model is formulated using an edge-based approach described by a probability generating function. The basic reproduction number is computed...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00769-0
更新日期:2020-07-16 00:00:00
abstract::Metaecoepidemic models generalize metapopulation systems, combining local population dynamics with inter-patch migration coupled with an epidemic proliferation. A resource-consumer model is introduced with an ecosystem composed by two patches, in which consumers can freely move. A disease affects resources of the seco...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00764-5
更新日期:2020-07-07 00:00:00
abstract::Viruses that infect bacteria, i.e., bacteriophage or 'phage,' are increasingly considered as treatment options for the control and clearance of bacterial infections, particularly as compassionate use therapy for multi-drug-resistant infections. In practice, clinical use of phage often involves the application of multi...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00751-w
更新日期:2020-06-12 00:00:00
abstract::Here, we consider a game-theoretic model of multilevel selection in which individuals compete based on their payoff and groups also compete based on the average payoff of group members. Our focus is on multilevel social dilemmas: games in which individuals are best off cheating, while groups of individuals do best whe...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00742-x
更新日期:2020-05-30 00:00:00
abstract::Over the last 25 years, reforms in undergraduate biology education have transformed the way biology is taught at many institutions of higher education. This has been fueled in part by a burgeoning discipline-based education research community, which has advocated for evidence-based instructional practices based on fin...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00739-6
更新日期:2020-05-13 00:00:00
abstract::The origin of the modern genetic code and the mechanisms that have contributed to its present form raise many questions. The main goal of this work is to test two hypotheses concerning the development of the genetic code for their compatibility and complementarity and see if they could benefit from each other. On the ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00724-z
更新日期:2020-04-04 00:00:00
abstract::Hair loss in the autoimmune disease, alopecia areata (AA), is characterized by the appearance of circularly spreading alopecic lesions in seemingly healthy skin. The distinct spatial patterns of AA lesions form because the immune system attacks hair follicle cells that are in the process of producing hair shaft, catap...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00707-0
更新日期:2020-02-24 00:00:00
abstract::Classical evolutionary game theory (EGT) focuses on competition among phenotypes while assuming asexual transmission of these phenotypes to the next generation. However, phenotypic selection and sexual recombination are not necessarily mutually reinforcing in populations with sexual reproduction. In particular, it has...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-020-00705-2
更新日期:2020-02-06 00:00:00
abstract::Cancer is a complex phenomenon, and the sheer variation in behaviour across different types renders it difficult to ascertain underlying biological mechanisms. Experimental approaches frequently yield conflicting results for myriad reasons, and mathematical modelling of cancer is a vital tool to explore what we cannot...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00677-y
更新日期:2020-01-22 00:00:00
abstract::The asymptotes and transition points of the net CO2 assimilation (A/Ci) rate curves of the steady-state Farquhar-von Caemmerer-Berry (FvCB) model for leaf photosynthesis of C3 plants are examined in a theoretical study, which begins from the exploration of the standard equations of hyperbolae after rotating the coordi...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00676-z
更新日期:2019-12-23 00:00:00
abstract::We investigate how the structure of interactions between coupled oscillators influences the formation of asynchronous patterns in a multilayer network by formulating a simple, general multilayer oscillator model. We demonstrate the analysis of this model in three-oscillator systems, illustrating the role of interactio...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00682-1
更新日期:2019-12-20 00:00:00
abstract::Population management using artificial gene drives (alleles biasing inheritance, increasing their own transmission to offspring) is becoming a realistic possibility with the development of CRISPR-Cas genetic engineering. A gene drive may, however, have to be stopped. "Antidotes" (brakes) have been suggested, but have ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00668-z
更新日期:2019-12-01 00:00:00
abstract::We present an improved mathematical model of population dynamics of mosquito-borne disease transmission. Our model considers the effect of mosquito repellent use and the mosquito's behavior or attraction to the infected human, which cause mosquitoes' biased distribution around the human population. Our analysis of the...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00666-1
更新日期:2019-12-01 00:00:00
abstract::We focus on discrete-time infectious disease models in populations that are governed by constant, geometric, Beverton-Holt or Ricker demographic equations, and give a method for computing the basic reproduction number, [Formula: see text]. When [Formula: see text] and the demographic population dynamics are asymptotic...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0426-2
更新日期:2019-11-01 00:00:00
abstract::In this paper, we use multiple scale homogenisation to derive a set of averaged macroscale equations that describe the movement of nutrients in partially saturated soil that contains growing potato tubers. The soil is modelled as a poroelastic material, which is deformed by the growth of the tubers, where the growth o...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00656-3
更新日期:2019-10-01 00:00:00
abstract::Rigorously calibrating dynamic models with time-series data can pose roadblocks. Oftentimes, the problem is ill-posed and one has to rely on appropriate regularization techniques to ensure stable parameter estimation from which forward projections with quantified uncertainty could be generated. If the inversion proced...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00650-9
更新日期:2019-10-01 00:00:00
abstract::Systemic chemotherapy is one of the main anticancer treatments used for most kinds of clinically diagnosed tumors. However, the efficacy of these drugs can be hampered by the physical attributes of the tumor tissue, such as tortuous vasculature, dense and fibrous extracellular matrix, irregular cellular architecture, ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0402-x
更新日期:2019-09-01 00:00:00
abstract::Evidence suggests that many G protein-coupled receptors (GPCRs) are bound together forming dimers. The implications of dimerisation for cellular signalling outcomes, and ultimately drug discovery and therapeutics, remain unclear. Consideration of ligand binding and signalling via receptor dimers is therefore required ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-017-0387-x
更新日期:2019-09-01 00:00:00
abstract::An algorithm for computing the linear noise approximation (LNA) of the reaction-diffusion master equation (RDME) is developed and tested. The RDME is often used as a model for biochemical reaction networks. The LNA is derived for a general discretization of the spatial domain of the problem. If M is the number of chem...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0428-0
更新日期:2019-08-01 00:00:00
abstract::Cell migration plays an important role in physiology and pathophysiology. It was observed in the experiments that cells, such as fibroblast, leukocytes, and cancer cells, exhibit a wide variety of migratory behaviors, such as persistent random walk, contact inhibition of locomotion, and ordered behaviors. To identify ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00585-1
更新日期:2019-08-01 00:00:00
abstract::The present paper studies a predator-prey fishery model which incorporates the independent harvesting strategies and nonlinear impact of an anthropogenic toxicant. Both fish populations are harvested with different harvesting efforts, and the cases for the presence and non-presence of harvesting effort are discussed. ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00627-8
更新日期:2019-07-01 00:00:00
abstract::Recent discoveries in ecological stoichiometry have indicated that food quality in terms of the phosphorus/carbon (P/C) ratio affects consumers whether the imbalance involves insufficient or excess nutrients. This phenomenon is called the "stoichiometric P/C knife-edge." In this study, we develop and analyze a produce...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00629-6
更新日期:2019-07-01 00:00:00
abstract::Bacterial quorum sensing (QS) is a form of intercellular communication that relies on the production and detection of diffusive signaling molecules called autoinducers. Such a mechanism allows the bacteria to track their cell density in order to regulate group behavior, such as biofilm formation and bioluminescence. I...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-019-00570-8
更新日期:2019-05-01 00:00:00
abstract::Bistability and multistationarity are properties of reaction networks linked to switch-like responses and connected to cell memory and cell decision making. Determining whether and when a network exhibits bistability is a hard and open mathematical problem. One successful strategy consists of analyzing small networks ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-00555-z
更新日期:2019-04-01 00:00:00
abstract::A two-dimensional model for red blood cell motion is adapted to consider the dynamics of breast cancer cells in a microfluidic channel. Adjusting parameters to make the membrane stiffer, as is the case with breast cancer cells compared with red blood cells, allows the model to produce reasonable estimates of breast ca...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-00557-x
更新日期:2019-04-01 00:00:00
abstract::Human rabies is one of the major public health problems in China with an average of 1977 cases per year. It is estimated that 95% of these human rabies cases are due to dog bites. In recent years, the number of wildlife-associated human rabies cases has increased, particularly in the southeast and northeast regions of...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-00537-1
更新日期:2019-04-01 00:00:00
abstract::Microtubules (MTs) are protein filaments found in all eukaryotic cells which are crucial for many cellular processes including cell movement, cell differentiation, and cell division. Due to their role in cell division, they are often used as targets for chemotherapy drugs used in cancer treatment. Experimental studies...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0531-2
更新日期:2019-03-01 00:00:00
abstract::Temporal evolution of a clonal bacterial population is modelled taking into account reversible mutation and selection mechanisms. For the mutation model, an efficient algorithm is proposed to verify whether experimental data can be explained by this model. The selection-mutation model has unobservable fitness paramete...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0529-9
更新日期:2019-03-01 00:00:00
abstract::Coalescent models of evolution account for incomplete lineage sorting by specifying a species tree parameter which determines a distribution on gene trees, and consequently, a site pattern probability distribution. It has been shown that the unrooted topology of the species tree parameter of the multispecies coalescen...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0456-9
更新日期:2019-02-01 00:00:00
abstract::The Shapley value, a solution concept from cooperative game theory, has recently been considered for both unrooted and rooted phylogenetic trees. Here, we focus on the Shapley value of unrooted trees and first revisit the so-called split counts of a phylogenetic tree and the Shapley transformation matrix that allows f...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0392-8
更新日期:2019-02-01 00:00:00
abstract::Distinct electrophysiological phenotypes are exhibited by biological cells that have differentiated into particular cell types. The usual approach when simulating the cardiac electrophysiology of tissue that includes different cell types is to model the different cell types as occupying spatially distinct yet coupled ...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0516-1
更新日期:2019-01-01 00:00:00
abstract::We develop an age-structured ODE model to investigate the role of intermittent preventive treatment (IPT) in averting malaria-induced mortality in children, and its related cost in promoting the spread of antimalarial drug resistance. IPT, a malaria control strategy in which a full curative dose of an antimalarial med...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0524-1
更新日期:2019-01-01 00:00:00
abstract::Modellers of large-scale genome rearrangement events, in which segments of DNA are inverted, moved, swapped, or even inserted or deleted, have found a natural syntax in the language of permutations. Despite this, there has been a wide range of modelling choices, assumptions and interpretations that make navigating the...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0514-3
更新日期:2018-12-01 00:00:00
abstract::Cholera is an acute gastro-intestinal infection that affects millions of people throughout the world each year, primarily but not exclusively in developing countries. Because of its public health ramifications, considerable mathematical attention has been paid to the disease. Here we consider one neglected aspect of c...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0476-5
更新日期:2018-10-01 00:00:00
abstract::Aging in Caenorhabditis elegans is controlled, in part, by the insulin-like signaling and heat shock response pathways. Following thermal stress, expression levels of small heat shock protein-16.2 show a spatial patterning across the 20 intestinal cells that reside along the length of the worm. Here, we present a hypo...
journal_title:Bulletin of mathematical biology
pub_type: 杂志文章
doi:10.1007/s11538-018-0482-7
更新日期:2018-10-01 00:00:00