Abstract:
:Spatial oscillations of proteins in bacteria have recently attracted much attention. The cellular mechanism underlying these oscillations can be studied at molecular as well as at more macroscopic levels. We construct a minimal mathematical model with two proteins that is able to produce self-sustained regular pole-to-pole oscillations without having to take into account molecular details of the proteins and their interactions. The dynamics of the model is based solely on diffusion across the cell body and protein reactions at the poles, and is independent of stimuli coming from the environment. We solve the associated system of reaction-diffusion equations and perform a parameter scan to demonstrate robustness of the model for two possible sets of the reaction functions.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Rashkov P,Schmitt BA,Søgaard-Andersen L,Lenz P,Dahlke Sdoi
10.1007/s11538-012-9752-ysubject
Has Abstractpub_date
2012-09-01 00:00:00pages
2183-203issue
9eissn
0092-8240issn
1522-9602journal_volume
74pub_type
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