Abstract:
:We investigate the existence of oscillatory dynamics and multiple steady-state flow rates in a network with a simple topology and in vivo microvascular blood flow constitutive laws. Unlike many previous analytic studies, we employ the most biologically relevant models of the physical properties of whole blood. Through a combination of analytic and numeric techniques, we predict in a series of two-parameter bifurcation diagrams a range of dynamical behaviors, including multiple equilibria flow configurations, simple oscillations in volumetric flow rate, and multiple coexistent limit cycles at physically realizable parameters. We show that complexity in network topology is not necessary for complex behaviors to arise and that nonlinear rheology, in particular the plasma skimming effect, is sufficient to support oscillatory dynamics similar to those observed in vivo.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Karst NJ,Storey BD,Geddes JBdoi
10.1007/s11538-015-0089-1subject
Has Abstractpub_date
2015-07-01 00:00:00pages
1377-400issue
7eissn
0092-8240issn
1522-9602journal_volume
77pub_type
杂志文章abstract::This paper considers plant-pollinator systems in which plants are divided into two categories: The plants that secret a substantial volume of nectar in their flowers are called secretors, while those without secreting nectar are called nonsecretors (cheaters). The interaction between pollinators and secretors is mutua...
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journal_title:Bulletin of mathematical biology
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