Abstract:
:A dynamic model for cell differentiation, where cells with internal chemical reaction dynamics interact with each other and replicate was studied. It led to spontaneous differentiation of cells and determination, as discussed in the isologous diversification. The following features of the differentiation were obtained: (1) hierarchical differentiation from a 'stem' cell to other cell types, with the emergence of the interaction-dependent rules for differentiation; (2) global stability of an ensemble of cells consisting of several cell types, that were sustained by the emergent, autonomous control on the rate of differentiation; (3) existence of several cell colonies with different cell-type distributions. The results provide a novel viewpoint on the origin of a complex cell society, while relevance to some biological problems, especially to the hemopoietic system, is also discussed.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Furusawa C,Kaneko Kdoi
10.1006/bulm.1997.0034subject
Has Abstractpub_date
1998-07-01 00:00:00pages
659-87issue
4eissn
0092-8240issn
1522-9602pii
S0092-8240(97)90034-3journal_volume
60pub_type
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