Emergence of rules in cell society: differentiation, hierarchy, and stability.

Abstract:

:A dynamic model for cell differentiation, where cells with internal chemical reaction dynamics interact with each other and replicate was studied. It led to spontaneous differentiation of cells and determination, as discussed in the isologous diversification. The following features of the differentiation were obtained: (1) hierarchical differentiation from a 'stem' cell to other cell types, with the emergence of the interaction-dependent rules for differentiation; (2) global stability of an ensemble of cells consisting of several cell types, that were sustained by the emergent, autonomous control on the rate of differentiation; (3) existence of several cell colonies with different cell-type distributions. The results provide a novel viewpoint on the origin of a complex cell society, while relevance to some biological problems, especially to the hemopoietic system, is also discussed.

journal_name

Bull Math Biol

authors

Furusawa C,Kaneko K

doi

10.1006/bulm.1997.0034

subject

Has Abstract

pub_date

1998-07-01 00:00:00

pages

659-87

issue

4

eissn

0092-8240

issn

1522-9602

pii

S0092-8240(97)90034-3

journal_volume

60

pub_type

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