Mathematical Models for Immunology: Current State of the Art and Future Research Directions.

Abstract:

:The advances in genetics and biochemistry that have taken place over the last 10 years led to significant advances in experimental and clinical immunology. In turn, this has led to the development of new mathematical models to investigate qualitatively and quantitatively various open questions in immunology. In this study we present a review of some research areas in mathematical immunology that evolved over the last 10 years. To this end, we take a step-by-step approach in discussing a range of models derived to study the dynamics of both the innate and immune responses at the molecular, cellular and tissue scales. To emphasise the use of mathematics in modelling in this area, we also review some of the mathematical tools used to investigate these models. Finally, we discuss some future trends in both experimental immunology and mathematical immunology for the upcoming years.

journal_name

Bull Math Biol

authors

Eftimie R,Gillard JJ,Cantrell DA

doi

10.1007/s11538-016-0214-9

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2091-2134

issue

10

eissn

0092-8240

issn

1522-9602

pii

10.1007/s11538-016-0214-9

journal_volume

78

pub_type

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