The influence of fluid flow on modeling quorum sensing in bacterial biofilms.

Abstract:

:In this paper, we study quorum sensing in Pseudomonas aeruginosa biofilms. Quorum sensing is a process where bacteria monitor their population density through the release of extra-cellular signalling molecules. The presence of these molecules affects gene modulation leading to changes in behaviour such as the release of virulence factors. Here, we use numerical methods to approximate a 2-D model of quorum sensing. It is observed that the shape of the biofilm can have a profound effect on the onset of quorum sensing. This has serious repercussions for experimental observations since biofilms of the same biomass but different shapes can produce quite different results.

journal_name

Bull Math Biol

authors

Vaughan BL Jr,Smith BG,Chopp DL

doi

10.1007/s11538-009-9485-8

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

1143-65

issue

5

eissn

0092-8240

issn

1522-9602

journal_volume

72

pub_type

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