Abstract：
:Cell migration plays an important role in physiology and pathophysiology. It was observed in the experiments that cells, such as fibroblast, leukocytes, and cancer cells, exhibit a wide variety of migratory behaviors, such as persistent random walk, contact inhibition of locomotion, and ordered behaviors. To identify biophysical mechanisms for these cellular behaviors, we developed a rigorous computational model of cell migration on a two-dimensional non-deformable substrate. Cells in the model undergo motion driven by mechanical interactions between cellular protrusions and the substrate via the balance of tensile forces. Properties of dynamic formation of lamellipodia induced the persistent random walk behavior of a migrating cell. When multiple cells are included in the simulation, the model recapitulated the contact inhibition of locomotion between cells at low density without any phenomenological assumptions or momentum transfer. Instead, the model showed that contact inhibition of locomotion can emerge via indirect interactions between the cells through their interactions with the underlying substrate. At high density, contact inhibition of locomotion between numerous cells gave rise to confined motions or ordered behaviors, depending on cell density and how likely lamellipodia turn over due to contact with other cells. Results in our study suggest that various collective migratory behaviors may emerge without more restrictive assumptions or direct cell-to-cell biomechanical interactions.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Hassan AR,Biel T,Umulis DM,Kim Tdoi
10.1007/s11538-019-00585-1subject
Has Abstractpub_date
2019-08-01 00:00:00pages
3301-3321issue
8eissn
0092-8240issn
1522-9602pii
10.1007/s11538-019-00585-1journal_volume
81pub_type
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