解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The use of electrospun scaffolds for neural tissue engineering applications allows a closer mimicry of the native tissue extracellular matrix (ECM), important for the transplantation of cells in vivo. Moreover, the role of the electrospun fiber mat topography on neural stem cell (NSC) differentiation remains to be com...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2021.01.001
更新日期:2021-01-07 00:00:00
abstract::Heat shock proteins (Hsps) are involved in several important aspects of the cell proteostasis. Hsp90 interacts with at least a tenth of the cell proteome helping a large number of proteins to fold correctly. Hsp90 function is modulated by several co-chaperones having TPR (tetratricopeptide repeat) domains that allow f...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.12.017
更新日期:2021-01-06 00:00:00
abstract::The quest for effective anticancer therapeutics continues to be extensively pursued. Over the past century, several drugs have been developed, however, a majority of these drugs have a poor therapeutic index and increased toxicity profile. Hence, there still exists ample opportunity to discover safe and effective anti...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.12.024
更新日期:2021-01-06 00:00:00
abstract::The emergence of drug-resistant Mycobacterium tuberculosis (Mtb) stains has escalated the need for developing more efficient drugs and therapeutic strategies against tuberculosis. Here we functionally annotate a secretory mycobacterial asparaginase Rv1538c (MtA) and describe its biochemical properties. MtA primarily e...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.12.023
更新日期:2021-01-05 00:00:00
abstract::Oxidative stress is the main mechanism behind efficient disinfectants, causing damage in bacterial macromolecules. Importantly, bacteria activate resistance mechanisms in response to damage generated by oxidative stress. Strategies allowing pathogens to survive oxidative stress are highly conserved among microorganism...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.11.009
更新日期:2021-01-01 00:00:00
abstract::Split luciferase complementary assay has been used to investigate the effect of WD domain deletion on Apaf-1 oligomerization. Apaf-1 is an adaptor molecule in formation of apoptosome that activates caspase-9, an activation that is a key event in the mitochondrial cell death pathway. Structural studies suggest that nor...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.10.013
更新日期:2021-01-01 00:00:00
abstract::rBmTI-A is a recombinant serine protease inhibitor that belongs to the Kunitz-BPTI family and that was cloned from Rhipicephalus microplus tick. rBmTI-A has inhibitory activities on bovine trypsin, human plasma kallikrein, human neutrophil elastase and plasmin with dissociation constants in nM range. It is characteriz...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.12.014
更新日期:2020-12-24 00:00:00
abstract::Tryptocidine C (TpcC, cyclo[D-Phe1-Pro2-Trp3-D-Trp4-Asn5-Gln6-Trp7-Val8-Orn9-Leu10]) is a broad-spectrum antimicrobial peptide in the tyrothricin complex produced by a soil bacterium, Brevibacillus parabrevis. Electrospray mass spectrometric studies reveal the oligomerisation of TpcC into dimers and higher oligomers, ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.12.006
更新日期:2020-12-18 00:00:00
abstract::Acinetobacter baumannii encodes all enzymes required in the tricarboxylic acid (TCA) cycle and glyoxylate bypass except for isocitrate dehydrogenase kinase/phosphatase (IDHKP), which can phosphorylate isocitrate dehydrogenase (IDH) at a substrate-binding Ser site and control the carbon flux in enterobacteria, such as ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.12.001
更新日期:2020-12-05 00:00:00
abstract::Protein 3D structures support their biological functions. As the number of protein structures is negligible in regards to the number of available protein sequences, prediction methodologies relying only on protein sequences are essential tools. In this field, protein secondary structure prediction (PSSPs) is a mature ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.09.006
更新日期:2020-12-01 00:00:00
abstract::In around 10% of SARS-CoV-2 infected patients, coronavirus disease-2019 (Covid-19) symptoms are complicated with a severe lung damage called Acute Respiratory Distress Syndrome (ARDS), which is often lethal. ARDS is mainly associated with an uncontrolled overproduction of immune cells and cytokines, called "cytokine s...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2020.09.003
更新日期:2020-12-01 00:00:00
abstract::Microalgae are single-cell, photosynthetic organisms whose biodiversity places them at the forefront of biological producers of high-value molecules including lipids and pigments. Some of these organisms particular are capable of synthesizing n-3 very long chain polyunsaturated fatty acids (VLC-PUFAs), known to have b...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2020.04.022
更新日期:2020-11-01 00:00:00
abstract::Vegetable oils, consisting principally of triacylglycerols (TAG), are major sources of calories and essential fatty acids in the human diet. The fatty acid composition of TAG is a primary determinant of the nutritional quality and health-promoting properties of vegetable oils. TAG fatty acid composition also affects t...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2020.09.020
更新日期:2020-11-01 00:00:00
abstract::Diacylglycerol kinase (DGK) phosphorylates diacylglycerol to produce phosphatidic acid (PA). The η isozyme of DGK is abundantly expressed in C2C12 myoblasts. However, the role of DGKη in skeletal muscle cells remains unknown. In the present study, we showed that DGKη was downregulated at an early stage of myogenic dif...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.07.018
更新日期:2020-10-01 00:00:00
abstract::Kinetic parameters characterizing the catalytic activities of enzymes are typically investigated in dilute solutions. However, in reality, these reactions occur in cells that, in addition to water and ions, are full of other macromolecules including proteins, nucleic acids, lipids, and metabolites. Such a crowded envi...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.07.009
更新日期:2020-09-01 00:00:00
abstract::Glycogen was described as a temporal storage molecule in rhodococci, interconnecting lipids and carbon availability. The Rhodococcus jostii ADP-glucose pyrophosphorylase (ADP-GlcPPase) kinetic and regulatory properties support this role. Curiously, the enzyme uses glucosamine-1P as alternative substrate. Herein, we re...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.07.006
更新日期:2020-09-01 00:00:00
abstract::The protein "BCL-2-associated athanogene-1" (BAG-1), which exists in multiple isoforms, promotes cancer cell survival and is overexpressed in many different cancers. As a result, BAG-1-targeted therapy appears to be a promising strategy with which to treat cancer. It has previously been shown that the 5'UTR of the BAG...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.06.013
更新日期:2020-09-01 00:00:00
abstract::Regeneration is an adaptive phenomenon with wide biological implications spread heterogeneously in almost all the organism including human beings. The ability of regeneration varies from species to species for its complexity. Epimorphic regeneration of zebrafish caudal fin tissue is the most widely studied regeneratio...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.05.014
更新日期:2020-08-01 00:00:00
abstract::Sm and Sm-like (Lsm) proteins are considered as an evolutionary conserved family involved in RNA metabolism in organisms from bacteria and archaea to human. Currently, the function of Sm-like archaeal proteins (SmAP) is not well understood. Here, we report the crystal structures of SmAP proteins from Sulfolobus acidoc...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.05.001
更新日期:2020-08-01 00:00:00
abstract::The misfolding of amyloid proteins is closely correlated with the pathogenesis of protein conformation-related diseases, such as Alzheimer's disease (AD), prion disease, and type 2 diabetes mellitus (T2DM). The deposition of human islet amyloid polypeptide (hIAPP) and amyloid-β (Aβ) protein is entangled in AD and diab...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.04.012
更新日期:2020-07-01 00:00:00
abstract::High plasma choline has been associated with the metabolic syndrome and risk of chronic diseases, including cardiovascular disease. However, dietary choline is not correlated with choline plasma concentrations, and there are few studies and contradictory evidence regarding dietary choline and cardiovascular events. In...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.11.001
更新日期:2020-06-01 00:00:00
abstract::We have previously shown that withdrawal of folic acid led to metabolic reprogramming and a less aggressive phenotype in a mouse cell model of triple-negative breast cancer (TNBC). Herein, we evaluate the effects of folic acid withdrawal on transcriptomic profiles in these cells. Murine cell lines were originally deri...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.04.005
更新日期:2020-06-01 00:00:00
abstract::Hypertension is the leading cause of preventable mortality worldwide, contributing to over 9 million deaths per annum, predominantly owing to cardiovascular disease. The association of obesity, physical inactivity and alcohol with elevated blood pressure (BP) is firmly established. Weight loss or other dietary strateg...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2020.03.016
更新日期:2020-06-01 00:00:00
abstract::The proximity of cerebrospinal fluid (CSF) with the brain, its permanent renewal and better availability for research than tissue biopsies, as well as ganglioside (GG) shedding from brain to CSF, impelled lately the development of protocols for the characterization of these glycoconjugates and discovery of central ner...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.12.008
更新日期:2020-03-01 00:00:00
abstract::Nephropathy is one of the most frequent complications of chronic diabetes. The main reason for nephropathy despite being hyperglycemia, but it progresses even after good glycemic control has been achieved in diabetic patients. The effects of prior exposure to high blood glucose conditions depend upon the severity and ...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2020.01.007
更新日期:2020-03-01 00:00:00
abstract::Evidence shows that oral glycerol supplementation during the early stages of rat liver cancer reduces the growth of preneoplastic lesions. Besides, human hepatocellular carcinoma (HCC) cells display decreased expression of glycerol channel aquaporin 9 (AQP9) and also diminished glycerol-3-phosphate (G3P) content. Acco...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.01.002
更新日期:2020-03-01 00:00:00
abstract::The increasing prevalence of obesity and metabolic diseases is a worldwide public health concern, and the advent of new analytical technologies has made it possible to highlight the involvement of some molecules, such as sphingolipids (SL), in their pathophysiology. SL are constituents of cell membranes, lipoproteins ...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2019.10.003
更新日期:2020-02-01 00:00:00
abstract::Microalgae can produce large quantities of triacylglycerols (TAGs) and other neutral lipids that are suitable for making biofuels and as feedstocks for green chemistry. However, TAGs accumulate under stress conditions that also stop growth, leading to a trade-off between biomass production and TAG yield. Recently, in ...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2019.06.016
更新日期:2020-02-01 00:00:00
abstract::Porcine pancreatic extracts (PPE), also named pancreatin, are commonly used as a global source of pancreatic enzymes for enzyme replacement therapy in patients with exocrine pancreatic insufficiency. They are considered as a good substitute of human pancreatic enzymes and they have become a material of choice for in v...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.07.004
更新日期:2020-02-01 00:00:00
abstract::Many natural phyto-products as perezone (Per) exhibit anti-cancer activities. Using experimental and computational studies, it was described that Poly ADP-ribose polymerase 1(PARP-1) inhibition and the induction of oxidative stress state explain the pro-apoptotic activity of Per. The aim of this study was to evaluate ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.03.003
更新日期:2020-01-01 00:00:00
abstract::Although up to 25% of glucose released into circulation in the postabsorptive state comes from renal gluconeogenesis, the regulatory mechanisms of this process are still poorly recognized, comparing to hepatic ones. The aim of the present study was to examine if hypoxia-inducible factor-1 (HIF-1) might be involved in ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2020.02.002
更新日期:2020-01-01 00:00:00
abstract::A novel bgl1 gene, encoding GH3 family β-glucosidase from Penicillium verruculosum (PvBGL), was cloned and heterologously expressed in P. canescens RN3-11-7 (niaD-) strain under the control of the strong xylA gene promoter. The recombinant rPvBGL was purified and their properties were studied in comparison with those ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.11.009
更新日期:2020-01-01 00:00:00
abstract::Histone acetyltransferase (Hpa2) is an unusual acetyltransferase, with a wide range of substrates; including histones, polyamines and aminoglycosides antibiotic. Hpa2 belongs to GNAT superfamily and GNATs are well known for the formation of homo-oligomers. However, the reason behind their oligomerization remained unex...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.11.015
更新日期:2020-01-01 00:00:00
abstract::Gastrokine1 (GKN1), important for maintaining the physiological function of the gastric mucosa, is highly expressed in the stomach of healthy individuals but is down-regulated or absent in gastric tumor tissues and derived cell lines. The mechanisms underlying GKN1 gene inactivation are still unknown. We previously sh...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.09.005
更新日期:2019-12-01 00:00:00
abstract::Genome-editing technologies, in particular, CRISPR systems, are widely used for targeted regulation of gene expression and obtaining modified human and animal cell lines, plants, fungi, and animals with preassigned features. Despite being well described and easy to perform, the most common methods for construction and...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2019.09.003
更新日期:2019-12-01 00:00:00
abstract::Porphyromonas gingivalis uses a type IX secretion system (T9SS) to deliver more than 30 proteins to the bacterial surface using a conserved C-terminal domain (CTD) as an outer membrane translocation signal. On the surface, the CTD is cleaved and an anionic lipopolysaccharide (A-PLS) is attached by PorU sortase. Among ...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.06.010
更新日期:2019-11-01 00:00:00
abstract::Zika and Dengue viruses have attracted substantial attention from researchers in light of recent outbreaks of Dengue fever and increases in cases of congenital microcephaly in areas with Zika incidence. This review summarizes the current state of knowledge about Zika and Dengue proteases. These enzymes have several in...
journal_title:Biochimie
pub_type: 杂志文章,评审
doi:10.1016/j.biochi.2019.05.004
更新日期:2019-11-01 00:00:00
abstract::Since 2012, the interest for TMEM165 increased due to its implication in a rare genetic human disease named TMEM165-CDG (Congenital Disorder(s) of Glycosylation). TMEM165 is a Golgi localized protein, highly conserved through evolution and belonging to the uncharacterized protein family 0016 (UPF0016). Although the pr...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.07.016
更新日期:2019-10-01 00:00:00
abstract::High glucose (HG)-induced podocyte injury contributes to the pathogenesis of diabetic nephropathy, a severe complication of diabetes. Bromodomain-containing protein 4 (BRD4) has emerged as a critical regulator for cell injury. However, whether BRD4 participates in HG-induced podocyte injury remains unclear. In this st...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.07.012
更新日期:2019-10-01 00:00:00
abstract::Dysfunction in lipid metabolism may result in a decrease in hepatic autophagy, which contributes to the pathogenesis of non-alcoholic steatohepatitis. ATP-binding cassette transporter A1 transports free cholesterol and phospholipids to apolipoprotein A-I (apoA-I) to form nascent high-density lipoprotein particles. Res...
journal_title:Biochimie
pub_type: 杂志文章
doi:10.1016/j.biochi.2019.08.001
更新日期:2019-10-01 00:00:00