Abstract：
:Nephropathy is one of the most frequent complications of chronic diabetes. The main reason for nephropathy despite being hyperglycemia, but it progresses even after good glycemic control has been achieved in diabetic patients. The effects of prior exposure to high blood glucose conditions depend upon the severity and duration of this exposure, indicating a "metabolic memory" phenomenon. Hyperglycemia not only increases oxidative stress but is also alleged to start several biochemical anomalies and alter gene expression associated with metabolic homeostasis. High glucose levels induce epigenetic modifications that alter gene expression without changing DNA sequences. These epigenetic modifications have shown to be reversible and have the potential to cease adverse effects if good glycemic control is achieved from initiation of diabetes. However, if good glycemic control is not achieved for months, these modifications stand firm to reversals. Therapies and drugs have been in use to prevent epigenetic modifications and oxidative stress, which also helped in ameliorating diabetic nephropathy. But these synthetic drugs are loaded with side effects like increased body weight, kidney dysfunction etc. So phytochemicals are emerging as alternatives and many of them have already been used to treat nephropathy. But still, there is rigorous need to evaluate phytochemicals which can regulate epigenetic events and have the potential to decelerate the further progression of these life-threatening diseases. In this review article we discuss the potential epigenetic modifiers from plants that can erase metabolic memory and can thus be protective against diabetic nephropathy.
journal_name
Biochimiejournal_title
Biochimieauthors
Kushwaha K,Sharma S,Gupta Jdoi
10.1016/j.biochi.2020.01.007subject
Has Abstractpub_date
2020-03-01 00:00:00pages
140-151eissn
0300-9084issn
1638-6183pii
S0300-9084(20)30009-2journal_volume
170pub_type
杂志文章,评审相关文献
BIOCHIMIE文献大全abstract：:By use of procollagen proline hydroxylas which catalyses the substitution of the hydrogen in the trans position on carbon 4 with an hydroxyl on L-proline residues of procollagen, we have shown that the L-[3H-4] proline product of C.E.N. Saclay contained 29 per cent of the trans and 71 per cent of the cis form. It was ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(76)80433-6
更新日期：1976-01-01 00:00:00
abstract：:In recent years the chaperone HSC-70 has become a target for drug design with a strong focus in anticancer therapies. In our study of possible inhibitors of HSC-70 enzymatic activity we screened compounds by NMR as well as X-ray crystallography. As part of our screening efforts we crystallized the human HSC-70 ATP bin...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.11.012
更新日期：2015-01-01 00:00:00
abstract：:A nuclear poly(ADP-ribose) polymerase (PARP) is activated by gamma-irradiation and consequently synthesizes poly(ADP-ribose) by binding to DNA strand-breaks. This property suggests that PARP is a DNA strand-break-signal generator. Meanwhile, the cell-cycle arrest occurs in G1 and G2 phases following gamma-irradiation....
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/0300-9084(96)88161-2
更新日期：1995-01-01 00:00:00
abstract：:The binding of Ca2+ to membrane models composed of diplamitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine (DPPE) 15N-labeled in the polar head group was investigated at pH 8.5 and pH 9.4 by 15N-NMR spectroscopy. Both phospholipids exhibit a decrease in the chemical shift anisotropy, indicating c...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(89)90143-0
更新日期：1989-01-01 00:00:00
abstract：:The amino acid sequence of rat thymus histone obtained in highly purified form by preparative electrophoresis, was determined. This sequence is identical to the sequence of calf thymus histone H2B. The in vitro phosphorylation of the rat histone with a cyclic AMP-dependent protein kinase isolated from rat pancreas led...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(79)80313-2
更新日期：1979-01-01 00:00:00
abstract：BACKGROUND:Fatty acids (FAs), and especially monounsaturated FAs (MUFAs) stimulate GLP-1 release. However, lipotoxicity is indicated in GLP-1 secreting cells following long-term exposure to elevated levels of saturated FAs (SFAs) in vivo and in vitro, where in vitro studies indicate that cosupplementation with MUFAs co...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2018.11.017
更新日期：2019-04-01 00:00:00
abstract：:The combination of cDNA and RNA sequencing techniques has enabled determination of the complete sequence of one of the mRNAs coding for the precursor of the small subunit of ribulose bisphosphate carboxylase of Nicotiana sylvestris. In this 898-nucleotide-long mRNA, 540 nucleotides code for the entire 180-amino-acid-l...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(84)90148-2
更新日期：1984-07-01 00:00:00
abstract：:Leishmania is a unicellular protozoan parasite which causes leishmaniasis, a neglected tropical disease. It possess a unique thiol metabolism comprising of several proteins among which, tryparedoxin (cTXN) and tryparedoxin peroxidase (cTXNPx), function in concert as oxidoreductases, utilizing trypanothione as a source...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.12.017
更新日期：2016-02-01 00:00:00
abstract：:Strains of Escherichia, Salmonella, Shigella and Yersinia actively enter eukaryotic cells. Several techniques were used to compare and contrast the invasion mechanisms of Salmonella cholerae-suis, Yersinia enterocolitica and Shigella flexneri. Three animal cell lines (CHO, HEp-2 and MDCK) were examined for susceptibil...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(88)90271-4
更新日期：1988-08-01 00:00:00
abstract：:Affinity chromatography on cross-linked starch affords a simple and rapid procedure for alpha-amylases (EC 3.2.1.1.) purification. When starch is cross-linked in alkaline medium by epichlorhydrin in the conditions described, the insoluble polysaccharide obtained is able to retain specifically the alpha-amylase which i...
journal_title：Biochimie
pub_type： 杂志文章
doi：
更新日期：1976-01-01 00:00:00
abstract：:The synthesis of S100 protein increases toward the end of the exponential phase of growth of clonal rat glial cells C6 in monolayer culture. Moreover the synthesis of this protein can be increased by treatment of C6 cells with the lectin succinylated concanavalin A (succinyl ConA). In order to study the relationship b...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(84)80024-3
更新日期：1983-11-01 00:00:00
abstract：:Split luciferase complementary assay has been used to investigate the effect of WD domain deletion on Apaf-1 oligomerization. Apaf-1 is an adaptor molecule in formation of apoptosome that activates caspase-9, an activation that is a key event in the mitochondrial cell death pathway. Structural studies suggest that nor...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2020.10.013
更新日期：2021-01-01 00:00:00
abstract：:Experimental Lyme arthritis provides a mouse model for exploring the development of pathology following infection of C3H mice with Borrelia burgdorferi. Infected mice develop a reliable inflammatory arthritis of the ankle joint with severity that typically peaks around two to three weeks post-infection and then underg...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2017.06.010
更新日期：2017-10-01 00:00:00
abstract：:Pleurocidin (GWGSFFKKAAHVGKHVGKAALTHYL-NH(2)), found in skin mucous secretions of the winter flounder Pleuronectes americanus, is known to possess a high potency and broad-spectrum antimicrobial peptide without cytotoxicity. In this study, to investigate the impact of pleurocidin on apoptotic progress, we observed mor...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2011.07.011
更新日期：2011-10-01 00:00:00
abstract：:Surfactants carrying either a hydrocarbon or a fluorocarbon alkyl chain have been synthesized. The polar head was either tris(hydroxymethyl)acrylamidomethane (THAM), telomerized THAM, or a glycosylated THAM moiety. The aqueous solubility of some of these molecules was increased by oxidizing to a sulfoxide the thioethe...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(00)80017-6
更新日期：1998-05-01 00:00:00
abstract：:We have analyzed changes in the supercoiling of nucleoid DNA of murine fibroblasts cultured in the presence of hydralazine. The entire DNA attached to the nuclear matrix was extracted from the cells and sedimented in neutral sucrose density gradients containing ethidium bromide. Nucleoids from cells treated with hydra...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(98)80025-4
更新日期：1998-07-01 00:00:00
abstract：:The measurement and potential technological significance of in vivo missense errors are briefly reviewed. A recently developed approach is described in which reporter enzyme activity is generated by mistranslation of a gene coding for an inactive mutant form of the enzyme. Initial results obtained using the alpha subu...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/0300-9084(91)90192-4
更新日期：1991-12-01 00:00:00
abstract：:In order to identify conserved potential secondary structures within translational start sites, mRNA sequences derived from different species were studied with programs able to depict such features. The potential secondary structure of 71 bases around the initiator AUG or AUGs in the coding sequences of 290 eukaryotic...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(94)90120-1
更新日期：1994-01-01 00:00:00
abstract：:We isolated and purified the main lipids of the rat sciatic nerve. After methanolysis, fatty acids were isolated and purified by thin layer chromatography, and studied by gas chromatography. C 16 and C 18 fatty acids are the most abundant. Among the long-chain fatty acids, arachidonic acid (20:4) is present in some li...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(78)80202-8
更新日期：1978-01-01 00:00:00
abstract：:Pseudouridine [Ψ] is a frequent base modification in the ribosomal RNA [rRNA] and may be involved in the modulation of the conformational flexibility of rRNA helix-loop structures during protein synthesis. Helix 69 of 23S rRNA contains pseudouridines at the positions 1911, 1915 and 1917 which are formed by the helix 6...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2010.12.018
更新日期：2011-05-01 00:00:00
abstract：:Toyocamycin (TMC), an adenosine analog has been previously reported to inhibit both number and infectivity of retrovirus particles released by chronically infected cells (Bonar et al., 1970; Riman, 1971; Mauchauffé et al., 1979). We have previously shown that loss of infectivity could result from the incorporation of ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(81)80013-2
更新日期：1981-01-01 00:00:00
abstract：:Homeostasis in vivo is maintained by a highly complex network of positive and negative signals. At the cellular level, this regulatory microenvironment can be divided, in a simplified fashion, into two major compartments: the humoral compartment, including compounds such as hormones, growth factors and nutrients, and ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(88)90301-x
更新日期：1988-11-01 00:00:00
abstract：:Two soluble forms of brain glutamate dehydrogenase isoproteins were inactivated by pyridoxal 5'-phosphate. Restoration of catalytic activity can be accomplished by dialysis and addition of an excess of cysteine or lysine. Spectral evidence is presented to indicate that the inactivation proceeds through Schiff base for...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(97)84333-7
更新日期：1996-01-01 00:00:00
abstract：:EPR spectroscopy in conjunction with oxidation-reduction potentiometry has been used to determine the half-reduction potentials of the four hemes of cytochrome c3. As predicted, the four hemes of cytochrome c3 have different mid-point potentials. The Em values are: Heme I,--284 mV; Heme II,--310 mV; Heme III,--324 mV ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/s0300-9084(78)80829-3
更新日期：1978-01-01 00:00:00
abstract：:Caveolin is the protein marker of caveola-mediated endocytosis. Previously, we demonstrated by immunoblotting and immunofluorescence that an anti-chick embryo caveolin-1 monoclonal antibody (mAb) recognizes a protein in amoeba extracts. Nevertheless, the caveolin-1 gene is absent in the Entamoeba histolytica genome da...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2014.09.007
更新日期：2014-12-01 00:00:00
abstract：:Thraustochytrium is a marine protist producing a specific profile of nutritionally important fatty acids, including very long chain polyunsaturated fatty acids (VLCPUFAs) docosahexaenoic acid (DHA, 22:6n-3), even chain saturated fatty acids (SFAs) palmitic acid (16:0), and odd chain SFAs pentadecanoic acid (15:0). To ...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2017.10.024
更新日期：2018-01-01 00:00:00
abstract：:Beta-turmerin from turmeric (Curcuma longa) waste grits obtained after extraction of curcumin was purified by successive gel permeation chromatography. Homogeneity of beta-turmerin was confirmed by its movement as single band both in SDS-PAGE and as well as in native (basic) PAGE. The apparent molecular mass is approx...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2009.06.006
更新日期：2009-09-01 00:00:00
abstract：:The Cystic Fibrosis Transmembrane Regulator (CFTR) is a membrane protein whose mutations cause cystic fibrosis, a lethal genetic disease. We performed a molecular dynamic (MD) study of the properties of the nucleotide binding domains (NBD) whose conformational changes, upon ATP binding, are the direct responsible of t...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/j.biochi.2015.01.010
更新日期：2015-04-01 00:00:00
abstract：:The recF gene of E coli lies within a cluster of genes which play essential roles in DNA replication; the gene order is dnaA dnaN recF gyrB. Each of these genes has its own promoters which, with the exception of dnaA promoters, reside entirely within the translated region of the respective preceding gene. In this repo...
journal_title：Biochimie
pub_type： 杂志文章
doi：10.1016/0300-9084(91)90220-u
更新日期：1991-02-01 00:00:00
abstract：:Plasmalogens (Pls) represent a specific subclass of glycerophospholipids characterized by the presence of a vinyl-ether bond at the sn-1 position of glycerol. Pls are quantitatively important in membranes of neuronal tissues, including the brain and the retina, where they can represent until almost two-third of ethano...
journal_title：Biochimie
pub_type： 杂志文章,评审
doi：10.1016/j.biochi.2014.07.023
更新日期：2014-12-01 00:00:00
