abstract：:A significant pathological feature of refractory temporal lobe epilepsy (TLE) is neuronal loss. Oxidative stress caused by repeated seizures is an important mechanism leading to neuronal loss in hippocampus. Nicotinamide-adenine dinucleotide (NAD) a coenzyme that is involved in many biochemical oxidation-reduction rea...

journal_title：Brain research bulletin

authors： Wu H,Meng Q,Zhang Y,Li H,Liu Y,Dong S,Liu B,Zhang H

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Cerebral ischemic stroke (IS) threatens the daily life of individuals, with high mortality. Emerging studies have deciphered the independent roles of the long non-coding RNA growth-arrest-specific transcript 5 (GAS5), microRNA (miR)-455-5p and phosphatase and tensin homolog (PTEN) in IS, but the understanding...

journal_title：Brain research bulletin

authors： Wu R,Yun Q,Zhang J,Bao J

更新日期：2021-02-01 00:00:00

abstract：:Itch is an annoying sensation that always triggers scratching behavior, yet little is known about its transmission pathway in the central nervous system. Parabrachial nucleus (PBN), an essential transmission nucleus in the brainstem, has been proved to be the first relay station in itch sensation. Meanwhile, dorsal mi...

journal_title：Brain research bulletin

authors： Li JN,Ren JH,Zhao LJ,Wu XM,Li H,Dong YL,Li YQ

更新日期：2021-01-25 00:00:00

abstract：:Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the mature brain. At an early developmental period, it acts in an excitatory manner that influences many processes of proliferation, migration, and differentiation of the neurons. Previous evidence indicated that manipulation of the GABAergi...

journal_title：Brain research bulletin

authors： Naderipoor P,Amani M,Abedi A,Sakhaie N,Sadegzadeh F,Saadati H

更新日期：2021-01-10 00:00:00

abstract：:Carbon monoxide (CO) and nitric oxide (NO) modulate inflammatory nociception and anxiety. We evaluate whether treatments with a heme oxygenase-1 (HO-1) inducer (CoPP) or a carbon monoxide-releasing molecule (CORM-2) are capable of inhibiting inflammatory pain aversiveness in wild type (WT) and inducible nitric oxide s...

journal_title：Brain research bulletin

authors： Cazuza RA,Arantes ALF,Pol O,Leite-Panissi CRA

更新日期：2021-01-07 00:00:00

abstract：:Emerging evidence suggests that sleep deprivation (SD) is a public health epidemic and increase the risk of Alzheimer's disease (AD) progression. However, the underlying mechanisms remain to be fully investigated. In this study, we investigate the impact of 72 h SD on the prefrontal cortex (PFC) of 3∼4-months-old APP/...

journal_title：Brain research bulletin

authors： Tabassum S,Misrani A,Tabassum S,Ahmed A,Yang L,Long C

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Parkinson's disease (PD) is a frequent degenerative disease of the nervous system with undefined pathogenesis. This study explored the protective effect of microRNA (miR)-218-5p on dopaminergic neuron injury in substantia nigra (SN) of rats with PD through the regulation of LIM and SH3 domain protein 1 (LASP1...

journal_title：Brain research bulletin

authors： Ma X,Zhang H,Yin H,Geng S,Liu Y,Liu C,Zhao J,Liu Y,Wang X,Wang Y

更新日期：2021-01-01 00:00:00

abstract：:Five polymorphisms (rs4713916, rs4713902, rs1360780, rs9296158 and rs3800373) of FKBP5 gene were analyzed in a case-control study comprising 423 Mexican individuals (146 individuals with suicide attempt and 277 controls). The SNP's were genotyped using the TaqMan-allelic assay. Genotype and allele frequencies were com...

journal_title：Brain research bulletin

authors： Hernández-Díaz Y,González-Castro TB,Tovilla-Zárate CA,Juárez-Rojop IE,López-Narváez ML,Pérez-Hernández N,Rodríguez-Pérez JM,Genis-Mendoza AD

更新日期：2021-01-01 00:00:00

abstract：:Mouse models that replicate facets of human neurological diseases are often used at the pre-clinical stage to better understand the underlying mechanisms of a disease and test the target engagement of potential therapeutic interventions. We recently characterized a mouse model of childhood-onset parkinsonism-dystonia,...

journal_title：Brain research bulletin

authors： Giraldo G,Janus C

更新日期：2021-01-01 00:00:00

abstract：:Changes in dietary habits, including the increased consumption of processed foods, rich in trans fatty acids (TFA), have profound effects on offspring health in later life. Thus, this study aimed to assess the influence of maternal trans fat intake during pregnancy or lactation on anxiety behavior, as well as markers ...

journal_title：Brain research bulletin

authors： Pase CS,Metz VG,Roversi K,Roversi K,Vey LT,Dias VT,Schons CF,de David Antoniazzi CT,Duarte T,Duarte M,Burger ME

更新日期：2021-01-01 00:00:00

abstract：:This study aims to evaluate the neuroprotective effect of sodium butyrate against the pentylenetetrazol (PTZ)-induced kindling epilepsy. Sodium butyrate (SB) (5, 10 and 20 mg/kg) and sodium valproate for 40 days and PTZ (37 mg/kg) injection every day were conducted for Kunming mice, to investigate seizure intensity an...

journal_title：Brain research bulletin

authors： Li D,Bai X,Jiang Y,Cheng Y

更新日期：2020-12-28 00:00:00

abstract：:Isoflurane (ISO) is an anesthesia and can result in neuron injury. A previous study has indicated that microRNA-302b-3p (miR-302b-3p) exerts a crucial function in modulating cerebral ischemia/reperfusion damage-induced neuronal injury. We sought to examine the role of miR-302b-3p in ISO-induced neuronal injury. In the...

journal_title：Brain research bulletin

authors： Li L,Lu S,Fan X

更新日期：2020-12-25 00:00:00

abstract：:Spinal cord ischemia-reperfusion injury(SCII)affects nerve function through many mechanisms, which are complex and not fully understood. Recently, accumulating evidence has indicated that long noncoding RNAs (lncRNAs) play an increasingly important role in SCII. We investigated the role of lncRNA growth arrest-specifi...

journal_title：Brain research bulletin

authors： Zhang Z,Li X,Chen F,Li Z,Wang D,Ren X,Ma H

更新日期：2020-12-11 00:00:00

abstract：:Bone marrow mesenchymal stem cells (BMSCs) are involved in cancer initiation and metastasis, and sometimes mediate cell communication by releasing exosomes and delivering microRNAs (miRNAs). The study aims to investigate the effects of exosomal hsa-miR-23b-3p derived from human BMSCs on intracranial aneurysm (IA). Fir...

journal_title：Brain research bulletin

authors： Sun X,Zheng X,Zhang X,Zhang Y,Luo G

更新日期：2020-12-01 00:00:00

abstract：:Neuropathic pain (NP) is a challenge due to our limited understanding of the mechanisms that initiate and maintain chronic pain. The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is an important area of the emotional and cognitive components of pain and pharmacological systems can interact into the n...

journal_title：Brain research bulletin

authors： Medeiros P,Oliveira-Silva M,Negrini-Ferrari SE,Medeiros AC,Elias-Filho DH,Coimbra NC,de Freitas RL

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Statins are cholesterol lowering drugs that decrease the risk of cardiovascular events, but they are related with a few unfavorable symptoms in skeletal muscle including myopathy, and mild to moderate fatigue. Additionally, there has been discrepancies about the impacts of statins on brain and cognition. Thi...

journal_title：Brain research bulletin

authors： Okudan N,Belviranli M

更新日期：2020-12-01 00:00:00

abstract：:Glucokinase (GCK) may be involved in inflammatory pathological changes, while the P2X3 receptor in the stellate ganglia (SG) is related to diabetic cardiac autonomic neuropathy. In this study, we explored the relationship between the upregulated GCK in SG and diabetic cardiac sympathy. The expression and location of G...

journal_title：Brain research bulletin

authors： Xu X,Liu B,Yang J,Zou Y,Sun M,Li Z,Li L,Yang R,Zou L,Li G,Liu S,Li G,Liang S

更新日期：2020-12-01 00:00:00

abstract：:The effects of autophagy on neuronal damage can be positive or detrimental negative. Through establishing a model of fetal rat cortical neuron hydraulic shock injury, dipotassium bisperoxo (picolinoto) oxovanadate (V) [bpv(pic)] was used to inhibit PTEN at different time points post-injury and autophagy level after ne...

journal_title：Brain research bulletin

authors： Yu H,Shao J,Huang R,Guan Y,Li G,Chen S,Zhou F,Yao Q,Shen J

更新日期：2020-12-01 00:00:00

abstract：:Traumatic spinal cord injury (SCI) can lead to motor disturbance, sensory deficit, or autonomic dysfunction. The role of circRNAs in the pivotal physiopathological processes of SCI has been demonstrated recently. However, no similar research has been performed to explore the circRNAs involved in apoptosis after SCI. T...

journal_title：Brain research bulletin

authors： Yao Y,Wang J,He T,Li H,Hu J,Zheng M,Ding Y,Chen YY,Shen Y,Wang LL,Zhu Y

更新日期：2020-11-01 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a common neurological disease, causing severe disability and even deaths. Stem cell transplantation has been increasingly used in stroke therapy, and neural stem cells (NSCs) are a good source for stem cell transplantation. However, the regulatory mechanism of NSCs remains unclear. In...

journal_title：Brain research bulletin

authors： Sun Z,Wu K,Gu L,Huang L,Zhuge Q,Yang S,Wang Z

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND PURPOSE:DTNBP1 gene variation and lower dysbindin-1 protein are associated with schizophrenia. Previous evidence suggests that downregulated dysbindin-1 expression results in lower expression of copper transporters ATP7A (intracellular copper transporter) and SLC31A1 (CTR1; extracellular copper transport...

journal_title：Brain research bulletin

authors： Schoonover KE,McMeekin LJ,Farmer CB,Varghese NE,Queern SL,Lapi SE,Cowell RM,Roberts RC

更新日期：2020-11-01 00:00:00

abstract：:Nitric oxide plays a role in the long term potentiation mechanisms produced in the mammalian hippocampus during spatial learning. A great deal of data has demonstrated that the dorsolateral telencephalon of fish could be homologous to the mammalian hippocampus sharing functional similarities. In the present study, we ...

journal_title：Brain research bulletin

authors： Gómez Y,Vargas JP,López JC,Portavella M

更新日期：2020-11-01 00:00:00

abstract：:Every year, a large number of infants and young children worldwide are administered general anesthesia. Whether general anesthesia adversely affects the intellectual development and cognitive function of children at a later date remains controversial. Many animal experiments have shown that general anesthetics can cau...

journal_title：Brain research bulletin

authors： Yang F,Zhao H,Zhang K,Wu X,Liu H

更新日期：2020-11-01 00:00:00

abstract：:Cytochrome P450 2D (CYP2D) mediates the activation and inactivation of several classes of psychoactive drugs, including opioids, which can alter drug response. Tramadol is a synthetic opioid with analgesic activity of its own as well as being metabolically activated by CYP2D to O-desmethyltramadol (ODMST) an opioid re...

journal_title：Brain research bulletin

authors： McMillan DM,El-Sherbeni AA,Richards J,Tyndale RF

更新日期：2020-11-01 00:00:00

abstract：:Metformin (MET),an antidiabetic drug, has shown antioxidative and neuroprotective effects. In the present investigation, we aimed to study the probable effects of MET on cerebral ischemia/reperfusion in rats. Rats underwent cerebral ischemia/reperfusion and MET was administered orally at doses of 100 and 200 mg/kg for...

journal_title：Brain research bulletin

authors： Fatemi I,Saeed-Askari P,Hakimizadeh E,Kaeidi A,Esmaeil-Moghaddam S,Pak-Hashemi M,Allahtavakoli M

更新日期：2020-10-01 00:00:00

abstract：:Melatonin (Mel) has neuroprotective effects; however, its roles in hypoxic-ischemic brain damage (HIBD) and the underlying mechanisms remain unknown. We aimed to explore its roles and mechanisms in a HIBD rat model. We found that exogenous Mel treatment ameliorated HIBD-induced pathological changes, inhibited neuronal...

journal_title：Brain research bulletin

authors： Gou Z,Su X,Hu X,Zhou Y,Huang L,Fan Y,Li J,Lu L

更新日期：2020-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) constitutes a heterogeneous cerebral insult induced by traumatic biomechanical forces. Mitochondria play a critical role in brain bioenergetics, and TBI induces several consequences related with oxidative stress and excitotoxicity clearly demonstrated in different experimental model involv...

journal_title：Brain research bulletin

authors： Courtes AA,Gonçalves DF,Hartmann DD,da Rosa PC,Cassol G,Royes LFF,de Carvalho NR,Soares FAA

更新日期：2020-10-01 00:00:00

abstract：:Secondary brain injuries following intracerebral hemorrhage (ICH) are mediated by inflammatory pathway activation. The present study aimed to characterize long noncoding RNAs (lncRNAs) that are differentially expressed in cerebral tissues during ICH pathogenesis and to investigate their pathogenic functions. An ICH mo...

journal_title：Brain research bulletin

authors： Chen JX,Wang YP,Zhang X,Li GX,Zheng K,Duan CZ

更新日期：2020-09-01 00:00:00

abstract：:Previously obtained data suggests that noradrenaline (NE) released from the efferent locus coeruleus (LC) endings in hippocampal formation (HPC) may serve as an important modulating signal involved in the pharmacological mechanisms responsible for the production of type 2 theta rhythm in rats. Hence, two distinct hypo...

journal_title：Brain research bulletin

authors： Broncel A,Bocian R,Kłos-Wojtczak P,Konopacki J

更新日期：2020-09-01 00:00:00

abstract：:Diabetic mechanical allodynia (DMA) is a common manifestation in patients with diabetes mellitus, and currently, no effective treatment is available. Transient receptor potential vanilloid 4 (TRPV4) is involved in mechanical hypersensitivity resulting from varying aetiologies in animal, but its expression pattern duri...

journal_title：Brain research bulletin

authors： Cui YY,Li MY,Li YT,Ning JY,Gou XC,Shi J,Li YQ

更新日期：2020-09-01 00:00:00

abstract：:Vesicular glutamate transporter (VGLUT) 1 and VGLUT2 have been reported to distribute complementally in most brain regions and have been assumed to define distinct functional elements. Previous studies have shown the expression of VGLUT1 mRNA and VGLUT2 mRNA in the lateral reticular nucleus (LRN), a key precerebellar ...

journal_title：Brain research bulletin

authors： Li ZH,Zhang CK,Qiao Y,Ge SN,Zhang T,Li JL

更新日期：2020-09-01 00:00:00

abstract：:Wnt/β-catenin signaling plays an essential role in blood-brain barrier (BBB) formation and maintenance under pathophysiological conditions. HLY78, a lycorine derivative, has been identified as a novel activator of Wnt/β-catenin signaling in vitro. However, the effects of HLY78 on the BBB function in subarachnoid hemor...

journal_title：Brain research bulletin

authors： Luo X,Li L,Zheng W,Gu L,Zhang X,Li Y,Xie Z,Cheng Y

更新日期：2020-09-01 00:00:00

abstract：:Depression is a state of low mood and aversion to activity, affecting a person's thoughts, behavior, motivation, feelings and sense of well-being, which is associated with dramatical gene expression changes in hippocampus. Rodents induced by chronic unpredictable mild stress (CUMS) demonstrate typical depression-like ...

journal_title：Brain research bulletin

authors： Tao Y,Xie Z,Shi J,Ou R,Wu H,Shi H,Huang F,Wu X

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:We assessed the potential of resting-state fMRI lag analysis (RSLA) in detecting epileptic activation and in estimating anti-epileptic effects of Levetiracetam (LEV) in Rolandic epilepsy. METHODS:Forty-three children with Rolandic epilepsy underwent simultaneous EEG-fMRI. They were grouped into LEV vs drug-naï...

journal_title：Brain research bulletin

authors： Xu Q,Hu Z,Yang F,Bernhardt BC,Zhang Q,Stufflebeaskm SM,Zhang Z,Lu G

更新日期：2020-09-01 00:00:00

abstract：:Obesity and consumption of diet rich in fat are known to contribute to the development of Alzheimer's disease (AD) which is a complex and multifactorial neurodegenerative disease and a leading cause of mortality with unmet medical needs. Hypercholesterolemia was discovered to increase neuropathological changes along w...

journal_title：Brain research bulletin

authors： Zameer S,Alam M,Hussain S,Vohora D,Ali J,Najmi AK,Akhtar M

更新日期：2020-08-01 00:00:00

abstract：:Endocannabinoid system activity contributes to the homeostatic defense against aging and thus may counteract the progression of brain aging. The cannabinoid type 1 (CB1) receptor activity declines with aging in the brain, which impairs neuronal network integrity and cognitive functions. However, the underlying mechani...

journal_title：Brain research bulletin

authors： Kataoka K,Bilkei-Gorzo A,Nozaki C,Togo A,Nakamura K,Ohta K,Zimmer A,Asahi T

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To explore the unified and disease specific structural features of the brain in patients spanning six mental disorders who experience own-thought auditory verbal hallucinations (OTAVH). METHODS:A pilot study was conducted on 25 patients with schizophrenia (FUSCH-OTAVH), 20 patients with major depression diso...

journal_title：Brain research bulletin

authors： Zhuo C,Lin X,Wang C,Song X,Xu X,Li G,Xu Y,Tian H,Zhang Y,Wang W,Zhou C

更新日期：2020-07-01 00:00:00

abstract：:Intractable scratching is the characteristic of chronic itch, which represents a great challenge in clinical practice. However, the mechanism underlying chronic itch development is largely unknown. In the present study, we investigated the role of NMDA receptor in acute itch and in development of chronic itch. A mouse...

journal_title：Brain research bulletin

authors： Li NQ,Tang Y,Huang ST,Liu XT,Zeng LP,Li H,Wan L

更新日期：2020-05-01 00:00:00

abstract：:Sporadic Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder affected by amyloid and vascular pathogenesis. Brain insulin resistance (BIR) has been suggested as one of the pathomechanisms of sporadic AD. We investigated how the amyloid and vascular pathogenesis of AD interacts with BIR. We examined...

journal_title：Brain research bulletin

authors： Choi BR,Seo JH,Back DB,Han JS,Choi DH,Kwon KJ,Shin CY,Lee J,Kim HY

更新日期：2020-05-01 00:00:00

abstract：:Diabetic cardiac autonomic neuropathy (DCAN) is a serious complication of diabetes mellitus, which often leads to cardiac dysfunction and even threatens patients' life. Osthole, a natural coumarin derivative, has anti-inflammatory, anti-oxidant and antihypertensive effects. The P2X3 receptor is related to DCAN. The ob...

journal_title：Brain research bulletin

authors： Wu B,Sheng X,Xu Z,Zhang Y,Dan Y,Guo J,Peng H,Liang S,Li G

更新日期：2020-04-01 00:00:00