Abstract：
:Sporadic Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder affected by amyloid and vascular pathogenesis. Brain insulin resistance (BIR) has been suggested as one of the pathomechanisms of sporadic AD. We investigated how the amyloid and vascular pathogenesis of AD interacts with BIR. We examined experimental groups mimicking amyloid pathogenesis following intracerebroventriculr (icv) injection of amyloid β or vascular pathogenesis following permanent ligation of the bilateral common carotid arteries in Wistar rats that had undergone icv injection of streptozotocin. Behavioral tests and pathologic studies were performed. Cognitive impairments were induced by BIR superimposed by amyloid or vascular pathogenesis. Neuroinflammation in the white matter and hippocampus was aggravated by an interaction between BIR and vascular pathogenesis. Amyloid-associated pathology in the white matter was enhanced by BIR and vascular pathogenesis. Tau-associated pathology in the hippocampus was altered by BIR in a relation with amyloid or vascular pathogenesis. Our study may provide useful experimental insights based on an integrated approach to the influence of amyloid and vascular pathogenesis on BIR, permitting better understanding of the heterogeneous pathogenesis of sporadic AD. Pathologic responses in sporadic AD may differ depending on amyloid and vascular pathogenesis and may sometimes be synergistically aggravated when combined with BIR.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Choi BR,Seo JH,Back DB,Han JS,Choi DH,Kwon KJ,Shin CY,Lee J,Kim HYdoi
10.1016/j.brainresbull.2020.02.012subject
Has Abstractpub_date
2020-05-01 00:00:00pages
40-50eissn
0361-9230issn
1873-2747pii
S0361-9230(19)30895-0journal_volume
158pub_type
杂志文章abstract：:Individual cardiac nerves from which stimulation elicited cardioinhibition (bradycardia and negative inotropism) were identified in 24 of 38 dogs. Subsequently, 3-25 microliters of 30% horseradish peroxidase (HRP) were injected into an identified cardiac nerve. After a 3-day survival period, the medulla oblongata was ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(82)90073-9
更新日期：1982-04-01 00:00:00
abstract：:Previous studies suggest that hypnotizability represents a protective factor against the cardiac effects of cognitive stress and that hypnosis prevents vascular stress-induced modifications in highly hypnotizable individuals. The aim of the experiment was to investigate whether a similar effect at vascular level is pr...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.01.011
更新日期：2004-04-30 00:00:00
abstract：:Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy. α- (phenylselanyl) acetophenone (PSAP) is an organic selenium compound which has already demonstrated antioxidant, antidepressant and antin...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2018.07.007
更新日期：2018-09-01 00:00:00
abstract：:Chronic social stress and/or pharmacological treatments differentially modulate the expression of c-Fos, a marker of neuronal activity, in subregions of the rat brain. Here, we examined the effect of the atypical antipsychotic Clozapine (Clz) (20 mg/kg/day for 3 weeks) on the neuronal activation pattern of c-Fos prote...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2019.07.005
更新日期：2019-10-01 00:00:00
abstract：:Reports from both this laboratory and others indicate that prenatal exposure of rats to cocaine can produce alterations in development, activity and responses to environmental stimuli. In order to determine a biochemical basis for these effects, radioligand receptor-binding assays for different monoaminergic receptors...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90261-h
更新日期：1991-06-01 00:00:00
abstract：:The firing rate of the nerves innervating interscapular brown adipose tissue (IBAT), IBAT and colonic temperatures (TIBAT and Tc), heart rate, and oxygen (O2) consumption were monitored in urethane-anesthetized male Sprague-Dawley rats. These variables were measured for 40 min before (baseline values) and 40 min after...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)00032-a
更新日期：1995-01-01 00:00:00
abstract：:The effects of two indirect (dexfenfluramine and fluoxetine) and one direct (RU 24969) serotonergic agonists on diet selection over a 12-hr period were examined. Rats were habituated to eat, during the dark period, from two isoenergetic diets that differed in carbohydrate and protein content. Drugs were injected intra...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90130-r
更新日期：1990-06-01 00:00:00
abstract：:Catecholaminergic systems, specifically in the region of the lateral perifornical hypothalamus (PFH), have been linked to the inhibition of feeding behavior. The present studies examined the effects of d-amphetamine (AMPH), which is believed to act through the release of endogenous catecholamines (CAs), on spontaneous...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(86)90200-5
更新日期：1986-11-01 00:00:00
abstract：:Abundance of muscle spindles is most likely related to gradual recruitment and functional specialization of motor units, as well as to their fundamental role in reflex intermuscular interaction and cooperation with other sensory systems. Spindle afferents per se usually convey ambiguous kinesthetic information to the ...
journal_title：Brain research bulletin
pub_type： 评论,杂志文章
doi：10.1016/j.brainresbull.2007.12.002
更新日期：2008-03-28 00:00:00
abstract：:Electrophysiological responses to olfactory and gustatory stimuli were recorded in the same neural elements in the parabrachial nuclei (PbN) of rats under Flaxedil. Responses to olfactory stimuli varied in temporal pattern and magnitude from responses to gustatory stimuli. Intravenous infusion of Nembutal while record...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(85)90219-9
更新日期：1985-12-01 00:00:00
abstract：:How deep brain stimulation (DBS) acts and how the brain responds to it remains unclear. To investigate the mechanisms involved, we analyzed changes in local field potentials from the subthalamic area (STN-LFPs) recorded through the deep brain macroelectrode during monopolar DBS of the subthalamic nucleus area (STN-DBS...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.01.023
更新日期：2008-07-30 00:00:00
abstract：:In order to examine the effect of chronic neuroleptics on spinal dopaminergic system, rats were treated with haloperidol (0.5 mg/kg IP) for 21 days and the monosynaptic mass reflex (MMR) as well as dopamine (DA) metabolism were investigated. MMR, recorded from ventral root L6 following supramaximal stimulation to ipsi...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90240-x
更新日期：1992-01-01 00:00:00
abstract：OBJECTIVE:Transcranial near-infrared stimulation (tNIRS) can penetrate the scalp and skull and can reach the superficial layers of the cerebral cortex. In this study, we evaluated whether an 820-nm tNIRS can modulate the excitability of the primary motor cortex (M1) as measured by transcranial magnetic stimulation (TMS...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2019.12.007
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:Parkinson's disease (PD) is a frequent degenerative disease of the nervous system with undefined pathogenesis. This study explored the protective effect of microRNA (miR)-218-5p on dopaminergic neuron injury in substantia nigra (SN) of rats with PD through the regulation of LIM and SH3 domain protein 1 (LASP1...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.10.019
更新日期：2021-01-01 00:00:00
abstract：:Microtubule associated proteins are a heterogeneous group of proteins that have been implicated in regulating microtubule stability. They play an important role in the organisation of the neuronal cytoskeleton during neurite outgrowth, plasticity and regeneration. The fish visual system presents a considerable degree ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(01)00618-9
更新日期：2001-09-15 00:00:00
abstract：:Mouse models that replicate facets of human neurological diseases are often used at the pre-clinical stage to better understand the underlying mechanisms of a disease and test the target engagement of potential therapeutic interventions. We recently characterized a mouse model of childhood-onset parkinsonism-dystonia,...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.10.018
更新日期：2021-01-01 00:00:00
abstract：:Melanin was measured by a spectrophotofluorometric method in the brains of albino rats from birth to 20 months of age. The concentration of brain melanin increased from Day 1 until adult levels were reached at 1 month. Between 1 and 20 months of age no significant differences were found in brain melanin. Daily injecti...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(79)90014-5
更新日期：1979-11-01 00:00:00
abstract：:It has been demonstrated that the posteromedial cortical amygdaloid nucleus (PMCo), is sexually dimorphic. It is shown (Experiment 1) that male orchidectomy on the day of birth (D1) decreases the volume and number of neurons of the PMCo, while a single injection of propionate testosterone to the female on D1 masculini...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(00)00332-4
更新日期：2000-10-01 00:00:00
abstract：:The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for contr...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2003.12.005
更新日期：2004-03-01 00:00:00
abstract：:Recent in vivo electrophysiological studies in our laboratory demonstrated medial thalamus (MT) induced short-term facilitation in the middle layers of the anterior cingulate cortex (ACC). The aim of the present study was to investigate different forms of short-term plasticity (STP) in layer II/III of the ACC in an in...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2006.10.011
更新日期：2007-01-09 00:00:00
abstract：:Rats received bilateral intracerebroventricular (ICV) infusions of either AF64A (1.5 nmol/ventricle; n = 9) or vehicle (3.0 microliters/ventricle; n = 7). Four weeks later, the animals were anesthetized and their brains processed to visualize and quantify choline acetyltransferase (ChAT) immunoreactive (IR) and parval...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90125-2
更新日期：1994-01-01 00:00:00
abstract：:The polysialylated form of the neural cell adhesion molecule (PSA-NCAM) is involved in several morphogenetic processes of the central nervous system. In the present study the expression of PSA-NCAM has been investigated in the rat thalamus during embryonic and postnatal development using light and electron microscopic...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2006.11.015
更新日期：2007-03-30 00:00:00
abstract：:To examine synaptic input and association of terminals containing dopamine and other transmitters to rat striatal nitric oxide synthase-expressing neurons, an electron microscopic study using tyrosine hydroxylase (TH) immunohistochemistry combined with histochemistry for NADPH-diaphorase (NADPHd) was performed. NADPHd...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(96)00035-4
更新日期：1996-01-01 00:00:00
abstract：:Every year, a large number of infants and young children worldwide are administered general anesthesia. Whether general anesthesia adversely affects the intellectual development and cognitive function of children at a later date remains controversial. Many animal experiments have shown that general anesthetics can cau...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2020.08.003
更新日期：2020-11-01 00:00:00
abstract：:Inducing significant axon growth or regeneration after spinal cord injury has been difficult, primarily due to the poor growth supportive environment and low intrinsic growth ability of neurons within the CNS. Neurotrophins alone have been shown to readily induce regeneration of sensory axons after dorsal root lesions...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2010.05.013
更新日期：2011-03-10 00:00:00
abstract：:A modified synaptosomal superfusion apparatus is described which uses less than 10 micrograms of tissue per replicate sample and facilitates the routine separation of 3H-DA, 3H-DOPAC, and 3H-HVA. A flow rate of 1.5 ml/min allows superfusion without the use of reuptake or monoamine oxidase inhibitors. Superfusate sampl...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90232-o
更新日期：1990-09-01 00:00:00
abstract：:Specific angiotensin II (Ang II) binding sites are present in the dorsal medulla of several species, and dose-related cardiovascular effects are produced by microinjection of the peptide into this region. Because the anatomical location of Ang II binding sites in the area postrema (ap), nucleus tractus solitarii (nTS)...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(86)90217-0
更新日期：1986-10-01 00:00:00
abstract：:The pattern of NADPH-diaphorase expression was studied in the retina and optic tectum of the cichlid fish Tilapia mariae during the first developmental stages. NADPH-diaphorase activity was seen early, at hatching. In the retina a few cell bodies of the retinal inner nuclear layer showed a faint labeling. Scattered la...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(01)00451-8
更新日期：2001-03-15 00:00:00
abstract：:Since the second decade of this century it has been known that opiates can influence ingestive behaviors. Generally, opioid agents enhance feeding and opioid antagonists decrease feeding. The present paper reviews the responsiveness of different animal species to opiates in relation to ingestive behaviors, the opioid ...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/0361-9230(85)90116-9
更新日期：1985-06-01 00:00:00
abstract：:Methylphenidate (MPD), commonly known as Ritalin, is the most frequently prescribed drug to treat children and adults with attention deficit hyperactivity disorder (ADHD). Adolescence is a period of development involving numerous neuroplasticities throughout the central nervous system (CNS). Exposure to a psychostimul...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2006.09.019
更新日期：2006-12-11 00:00:00
