Abstract:
:The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for controlling neuroprotective gene expression. This study characterized the temporal and regional expression of a variety of proteins following ischemic injury induced by occlusion of the middle cerebral artery in rats. The results demonstrated upregulation of both c-Fos and FRA-2 in penumbral regions that preceded upregulation of the classic injury-associated proteins expressed by astrocytes and microglia and, in the case of FRA-2, appeared to correlate with neuronal survival. A further, previously undescribed, expression of FRA-2 in endothelial cells of the core ischemic region was also demonstrated.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Butler TL,Pennypacker KRdoi
10.1016/j.brainresbull.2003.12.005keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
65-73issue
1eissn
0361-9230issn
1873-2747pii
S0361923004000085journal_volume
63pub_type
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journal_title:Brain research bulletin
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