Abstract:
:Microtubule associated proteins are a heterogeneous group of proteins that have been implicated in regulating microtubule stability. They play an important role in the organisation of the neuronal cytoskeleton during neurite outgrowth, plasticity and regeneration. The fish visual system presents a considerable degree of plasticity. Thus, the retina grows continually throughout life and the optic nerve regenerates after crush. In the present study, we compared the distribution of the microtubule associated protein 1B in its phosphorylated form (MAP1B-phos) in the normal adult fish visual system with that observed during optic nerve regeneration after adult optic nerve crush using a specific monoclonal antibody mAb-150. Expression of MAP1B-phos was observed in some ganglion cell somata and in developing, growing axons within the control optic nerve. Few immunoreactive terminals were seen in the control optic tectum. After optic nerve crush, we found additional MAP1B-phos expression in regenerating axons throughout the visual system. Our results demonstrate that MAP1B-phos is present in growing and regenerating axons of fish retinal ganglion cells, which suggests that the phosphorylated form of MAP1B may play an important role in developmental and regeneration processes within the fish central nervous system.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Vecino E,Avila Jdoi
10.1016/s0361-9230(01)00618-9keywords:
subject
Has Abstractpub_date
2001-09-15 00:00:00pages
131-7issue
2eissn
0361-9230issn
1873-2747pii
S0361-9230(01)00618-9journal_volume
56pub_type
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journal_title:Brain research bulletin
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journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/0361-9230(81)90117-9
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/s0361-9230(99)00063-5
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00567-6
更新日期:2001-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2005.08.015
更新日期:2005-12-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:1993-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1988-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(87)90213-9
更新日期:1987-06-01 00:00:00