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Effects of acute and subacute administration of bicuculline on dopamine and muscarinic receptors in rat brain.

Abstract：

:The changes of characteristics of dopamine (D1 and D2) and muscarinic receptors after acute and subacute administration of bicuculline were examined in rat brain. The results demonstrated that in striatal region, the Bmax of D2 receptor was significantly increased with no change of affinity after subacute administration of bicuculline. However, neither Bmax nor Kd or the D2 receptor was changed after single administration. The characteristics of D1 receptor were not changed by either acute or subacute administration. The Bmax of muscarinic receptor in striatal area was significantly increased without changes of affinity after both a single and repeated administration of bicuculline. However, in hippocampus, the Bmax of muscarinic receptor was significantly decreased after subacute administration of bicuculline. The results suggest that the interactions among GABAergic, dopaminergic and cholinergic neuron exist in central nerve system.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Lim DK,Ito Y,Hoskins B,Ho IK

doi

10.1016/0361-9230(88)90114-1

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

21-4

issue

1

eissn

0361-9230

issn

1873-2747

pii

0361-9230(88)90114-1

journal_volume

21

pub_type

杂志文章

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