Involvement of endogenous opioids and ATP-sensitive potassium channels in the mediation of apomorphine-induced antinociception at the spinal level: a study using EMG planimetry of flexor reflex in rats.

abstract：:The effect of serotonin synthesis inhibitor, p-chlorophenylalanine (PCPA), on induction and maintenance of pseudopregnancy as indicated by deciduoma formation was examined in female rats. Animals were injected with 1 mg/kg b.wt. of reserpine on the day of metestrus, and silk thread was passed through and placed in the...

journal_title：Brain research bulletin

authors： Maekawa F,Yamanouchi K

更新日期：1996-01-01 00:00:00

abstract：:Single-unit recordings were made from lateral hypothalamic area (LHA) neurons of infant (8 through 21 days of age) male and female albino rats. Basal (or spontaneous) firing rates of LHA neurons were recorded for 20 min from rats 8 through 21 days of age, and mean basal firing rates did not differ across ages. Basal f...

journal_title：Brain research bulletin

authors： Almli CR,McMullen NT,Golden GT

更新日期：1976-11-01 00:00:00

abstract：:The non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) attenuates morphine-induced immediate-early gene expression in the rat striatum in a sexually dimorphic manner that depends in part on gonadal steroids. To determine if this effect was dependent on modulation of glutamate receptor...

journal_title：Brain research bulletin

authors： D'Souza DN,Harlan RE,Garcia MM

更新日期：2003-01-15 00:00:00

abstract：:Adenoviral vector directed gene transfer to rat facial motoneurons occurs efficiently following intra-parenchymal injection of relatively high dosages (> or =10(7) pfu per injection) of a prototype first generation adenoviral vector. However, high level of transgene expression, as observed during the first week follow...

journal_title：Brain research bulletin

authors： Hermens WT,Verhaagen J

更新日期：1998-09-15 00:00:00

abstract：:Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valua...

journal_title：Brain research bulletin

authors： Arendt T,Stieler JT,Holzer M

更新日期：2016-09-01 00:00:00

abstract：:In animal models of Fetal Alcohol Syndrome, ethanol causes a number of changes in brain development, with many of these changes being very transient. This is especially true for the process of synaptogenesis in different brain areas. Our quantitative electron microscopic study of synaptogenesis in the molecular layer ...

journal_title：Brain research bulletin

authors： Hoff SF

更新日期：1988-07-01 00:00:00

abstract：:Several works have shown that males and females differ in the ability to learn spatial locations in mazes. In this study, we used the Morris water maze to assess the acquisition of a spatial working memory (WM) task in adult male and female Wistar rats. The task consisted of a paired sample procedure made up of two da...

journal_title：Brain research bulletin

authors： Méndez-López M,Méndez M,López L,Arias JL

更新日期：2009-05-29 00:00:00

abstract：:Endogenous opioids (EO) probably do not modulate endotoxin (LPS)- or interleukin 1 (IL1)-induced fever because naloxone does not prevent its development. Yet, increases in CSF and hypothalamic levels of beta-endorphin have been reported during LPS-and IL1-induced fevers. Since IL1 also reduces the specific binding of ...

journal_title：Brain research bulletin

authors： Ahokas RA,Seydoux J,Llanos-Q J,Mashburn TA Jr,Blatteis CM

更新日期：1985-12-01 00:00:00

abstract：:This study aims to evaluate the neuroprotective effect of sodium butyrate against the pentylenetetrazol (PTZ)-induced kindling epilepsy. Sodium butyrate (SB) (5, 10 and 20 mg/kg) and sodium valproate for 40 days and PTZ (37 mg/kg) injection every day were conducted for Kunming mice, to investigate seizure intensity an...

journal_title：Brain research bulletin

authors： Li D,Bai X,Jiang Y,Cheng Y

更新日期：2020-12-28 00:00:00

abstract：:Current treatments for Parkinson's disease (PD) rely on a dopamine replacement strategy and are reasonably effective, particularly in the early stages of the disease. However, chronic dopaminergic therapy is limited by the development of a range of side effects, including dyskinesia. This has led to a search for alter...

journal_title：Brain research bulletin

authors： Monville C,Torres EM,Dunnett SB

更新日期：2005-12-15 00:00:00

abstract：:The present study investigates the protective effects of electroacupuncture (EA) application on cardiac function, while simultaneously exploring the underlying neurobiological mechanisms, in rats that have experienced thoracic surgery-induced stress. Mean arterial and left intraventricular pressures were monitored as ...

journal_title：Brain research bulletin

authors： Zhang HH,Chen J,Xia CM,Jiang MY,Wang J,Cao YX,Shen LL,Wang MY,Zhu DN

更新日期：2012-10-01 00:00:00

abstract：:The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for contr...

journal_title：Brain research bulletin

authors： Butler TL,Pennypacker KR

更新日期：2004-03-01 00:00:00

abstract：:Ongoing maternal behavior in rats is under the inhibitory influence of opiates. Exposure to drugs of abuse may result in a progressive and enduring enhancement of their reinforcing effects. Little attention has been paid to the possibility that puerperal treatment with morphine may lead to sensitization to this drug, ...

journal_title：Brain research bulletin

authors： Miranda-Paiva CM,Nasello AG,Yin AJ,Felicio LF

更新日期：2001-07-01 00:00:00

abstract：:Serotonin transporter (SERT) and brain-derived neurotrophic factor (BDNF) are key modulators of molecular signaling, cognition and behavior. Although SERT and BDNF mutant mouse phenotypes have been extensively characterized, little is known about their self-grooming behavior. Grooming represents an important behaviora...

journal_title：Brain research bulletin

authors： Kyzar EJ,Pham M,Roth A,Cachat J,Green J,Gaikwad S,Kalueff AV

更新日期：2012-12-01 00:00:00

abstract：:Regeneration following bilateral optic nerve crush was studied in groups of goldfish housed either on a standard diurnal cycle or under total light deprivation. Unoperated fish were included in each deprivation condition. Regeneration was only slightly delayed in the surgical group housed under light deprivation (68-8...

journal_title：Brain research bulletin

authors： Leitner DS,Francis A,Gazzaniga MS

更新日期：1982-01-01 00:00:00

abstract：:The non-adenosine nucleoside guanosine (Guo) was demonstrated to decrease quinolinic acid(QA)-induced seizures, spontaneously emerged absence epileptic seizures and lipopolysaccharide(LPS)-evoked induction of absence epileptic seizures suggesting its antiepileptic potential. It was also described previously that intra...

journal_title：Brain research bulletin

authors： Lakatos RK,Dobolyi Á,Todorov MI,Kékesi KA,Juhász G,Aleksza M,Kovács Z

更新日期：2016-06-01 00:00:00

abstract：:Peroxynitrite (ONOO-) is a strong biological oxidant formed by the diffusion-limited reaction of nitric oxide (NO-) and superoxide anion (O2-). It has long been theorized that peroxynitrite generation could be the cause in a number of pathological conditions ranging from atherosclerosis to inflammatory, autoimmune, he...

journal_title：Brain research bulletin

authors： Ramdial K,Franco MC,Estevez AG

更新日期：2017-07-01 00:00:00

abstract：:The role of several hippocampal innervations in the sensitivity to barbital-induced narcosis was studied in selected mice strains. The outbred and inbred mouse strains HS/lgb, SABRA/HUC, C57BL, CBA/LAC, and BALB/c were tested for barbital-induced sleep (315 mg/kg). The relatively short sleeping HS/lbg (HS) and the lon...

journal_title：Brain research bulletin

authors： Yanai J,Pick CG

更新日期：1995-01-01 00:00:00

abstract：:All the opiate-like peptides we tested (Met-enkephalin, (D-Ala2)-Met-enkephalin-NH2, beta-endorphin, (D-Ala2)-beta-endorphin, (D-Ala2)-alpha-endorphin, (D-Ala2)-gamma-endorphin) were capable of reducing distress vocalizations (DV's) in socially-isolated chicks when injected into the vicinity of the fourth ventricle in...

journal_title：Brain research bulletin

authors： Panksepp J,Vilberg T,Bean NJ,Coy DH,Kastin AJ

更新日期：1978-11-01 00:00:00

abstract：:We have examined the effects of the presence of the mutated human presenilin 1 gene (M146L; hps1*) on lesion-induced sprouting in the hippocampus of the mouse (C57/CBA). The entorhinal cortex was unilaterally lesioned with ibotenic acid in adult, male mice. Four weeks later the subsequent axonal sprouting in the denta...

journal_title：Brain research bulletin

authors： Kadish I,Pradier L,van Groen T

更新日期：2002-03-15 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a devastating subtype of stroke because it has few viable therapeutic options to intervene against primary or second brain injury. Recently, evidence has suggested that ferroptosis, a nonapoptotic form of cell death, is involved in ICH. In this study, we examined whether ICH-induced n...

journal_title：Brain research bulletin

authors： Chen B,Chen Z,Liu M,Gao X,Cheng Y,Wei Y,Wu Z,Cui D,Shang H

更新日期：2019-11-01 00:00:00

abstract：:Traumatic brain injury (TBI) constitutes a heterogeneous cerebral insult induced by traumatic biomechanical forces. Mitochondria play a critical role in brain bioenergetics, and TBI induces several consequences related with oxidative stress and excitotoxicity clearly demonstrated in different experimental model involv...

journal_title：Brain research bulletin

authors： Courtes AA,Gonçalves DF,Hartmann DD,da Rosa PC,Cassol G,Royes LFF,de Carvalho NR,Soares FAA

更新日期：2020-10-01 00:00:00

abstract：:Previous cytoarchitectural and electron micrographic studies have indicated that the gustatory zone of the nucleus of the solitary tract (NST) may contain local circuit neurons. It is known that neurons of the caudal "visceroceptive" NST contain GABA, glutamic acid decarboxylase (EC 4.1.1.15), and GABA-transaminase (G...

journal_title：Brain research bulletin

authors： Lasiter PS,Kachele DL

更新日期：1988-10-01 00:00:00

abstract：:To examine synaptic input and association of terminals containing dopamine and other transmitters to rat striatal nitric oxide synthase-expressing neurons, an electron microscopic study using tyrosine hydroxylase (TH) immunohistochemistry combined with histochemistry for NADPH-diaphorase (NADPHd) was performed. NADPHd...

journal_title：Brain research bulletin

authors： Fujiyama F,Masuko S

更新日期：1996-01-01 00:00:00

abstract：:GnRH release from hypothalamic explants from young and aged male Wistar-Kyoto rats was evaluated following stimulation with glutamate receptor agonists. Glutamate stimulated GnRH release to a similar extent in hypothalami from young and old animals, whereas N-methyl-D-Aspartate (NMDA) and kainate appeared more efficac...

journal_title：Brain research bulletin

authors： Sortino MA,Aleppo G,Scapagnini U,Canonico PL

更新日期：1996-01-01 00:00:00

abstract：:The failure of regenerating axons to grow within the adult mammalian central nervous system (CNS) does not apply to the olfactory bulb (OB). In this structure, normal and transected olfactory axons are able to enter, regenerate, and reestablish lost synaptic contacts with their targets, throughout the lifetime of the ...

journal_title：Brain research bulletin

authors： Ramón-Cueto A,Avila J

更新日期：1998-06-01 00:00:00

abstract：:The roles of prostaglandins (PGs) involved in opioidergic, cholinergic, and serotonergic regulation of the diurnal changes of tuberoinfundibular dopaminergic (TIDA) neuronal activities were investigated in ovariectomized, estrogen-treated rats. Treatment with naloxone [10 mg/kg, intraperitoneal (i.p.)], atropine (5 mg...

journal_title：Brain research bulletin

authors： Chu YC,Tsou MY,Pan JT

更新日期：2001-09-01 00:00:00

abstract：:Depression is the root of various diseases. It is one of the most debilitating conditions globally. Antidepressant drugs are usually the first-line of depression treatment. Arctigenin (ARC), one of active ingredient of Arctium lappa L, has been found to exert neuroprotective, anti-decrepitude, and anti-inflammatory ac...

journal_title：Brain research bulletin

authors： Du Y,Li W,Li Y,Yang J,Wang X,Yin S,Wang X,Velez de-la-Paz OI,Gao Y,Chen H,Yin X,Shi H

更新日期：2019-03-01 00:00:00

abstract：:The subiculum may be the key structure in the transfer of relevant processed information from the hippocampal formation to cortical areas. We investigated the location of the serotonin 1B receptor (5-HT1B) in the hippocampus with the specific ligand serotonin-O-carboxymethyl-glycyl[125I]tyrosinamide in rat brain secti...

journal_title：Brain research bulletin

authors： Aït Amara D,Segu L,Naïli S,Buhot MC

更新日期：1995-01-01 00:00:00

abstract：:Methylphenidate (MPD) is currently one of the most prescribed drug therapies for attention deficit/hyperactivity disorder (ADHD) and moreover is abused for cognitive enhancement and used for recreation by the young and adults. Methylphenidate is used for prolonged periods of time and its mechanism of action on the bra...

journal_title：Brain research bulletin

authors： Claussen C,Dafny N

更新日期：2012-03-10 00:00:00