Abstract：
:Adenoviral vector directed gene transfer to rat facial motoneurons occurs efficiently following intra-parenchymal injection of relatively high dosages (> or =10(7) pfu per injection) of a prototype first generation adenoviral vector. However, high level of transgene expression, as observed during the first week following administration of the adenoviral vector, declines during the second and third weeks and is associated with a local inflammatory response. In the present study rats were treated with dexamethasone to suppress the inflammatory response that occurs following administration of a first generation adenoviral vector and the effect of dexamethasone treatment on the duration of transgene expression was studied. Dexamethasone-treated rats displayed a reduced infiltration of macrophages and intra-parenchymal T-cells were not detectable at 14 days post-infusion of the viral vector. Transduced astrocytes persisted following treatment with dexamethasone, whereas only a few transduced motoneurons survived. In conclusion, suppression of inflammation by dexamethasone has a beneficial effect on the survival of transduced astroglial cells but exerts only moderate protection on transduced facial motoneurons.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Hermens WT,Verhaagen Jdoi
10.1016/s0361-9230(98)00042-2subject
Has Abstractpub_date
1998-09-15 00:00:00pages
133-40issue
2eissn
0361-9230issn
1873-2747pii
S0361923098000422journal_volume
47pub_type
杂志文章abstract：:Adaptation of the frog, Rana temporaria, to a white background for 12 hr has resulted in an intense formaldehyde-induced fluorescence (FIF) in the neurons of the preoptic recess organ (PRO), paraventricular organ (PVO), nucleus infundibularis dorsalis (NID) and their basal processes permitting visualization of the PRO...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(82)90184-8
更新日期：1982-07-01 00:00:00
abstract：:Nicotinic acetylcholine (ACh) and dopamine (DA) receptor activation has been found to be important for working memory. The regional distribution of these receptors in the brain has been well characterized. However, the relationship of the region-specific nicotinic ACh and DA binding density to memory performance has n...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(97)00009-9
更新日期：1997-01-01 00:00:00
abstract：:Rat sciatic nerves were transected and placed in a solution of HRP. Following perfusion, L4-6 spinal segments and sensory ganglia were cut into 60 micron sections. Alternate sections were processed with the glucose oxidase (GOD) or the benzidine dihydrochloride (BDHC) procedure. Sections were then either mounted on gl...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90154-5
更新日期：1983-04-01 00:00:00
abstract：:The topographical distribution of glutamate uptake, GABA uptake, and GAD activity was studied in caudal, intermediate and rostral areas of the nucleus of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the hypoglossal nu...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(85)90176-5
更新日期：1985-01-01 00:00:00
abstract：:The regeneration of brain tissue remains one of the greatest unsolved challenges in medicine and by many is considered unfeasible. Indeed, the adult mammalian brain does not regenerate tissue, but there is ongoing endogenous neurogenesis, which is upregulated after injury and contributes to tissue repair. This endogen...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2019.05.013
更新日期：2019-08-01 00:00:00
abstract：:Electrophysiologic response characteristics of mouse sciatic nerve and spinal cord were investigated following CNS infection with the temperature-sensitive (ts) vesicular stomatitis virus (VSV) mutant G31 KS5. Measurements were obtained before clinical symptoms of the virus-induced CNS disease appeared. Sciatic nerve ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90001-9
更新日期：1994-01-01 00:00:00
abstract：:We have found that thiamine-deficient (TD) rats show significant impairment of avoidance learning on the 25th day after the start of TD diet, as measured by passive-avoidance task. Administration of physostigmine (0.1 mg/kg, i.p.) from the 14th day after the start of TD diet improved the impairment of avoidance learni...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(00)00248-3
更新日期：2000-06-01 00:00:00
abstract：:In 1906, the first Nobel prize in the neurosciences was awarded jointly to Camillo Golgi and Santiago Ramón y Cajal in recognition of their work on the structure of the nervous system. The Nobel Prize in Physiology or Medicine linked together forever these two scientists. One century later, what remains of their oppos...
journal_title：Brain research bulletin
pub_type： 传,历史文章,杂志文章
doi：10.1016/j.brainresbull.2006.09.022
更新日期：2007-01-09 00:00:00
abstract：:To acquire knowledge about the environment two types of learning are necessary: declarative localizatory learning about where environmental cues and the subject are, and procedural learning about how to explore and move around the environment. Experimental data indicate that hippocampal regions are involved in spatial...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2006.06.006
更新日期：2006-10-16 00:00:00
abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over 60 years of age in the US and many other developed countries. Increasingly sophisticated methods for the diagnosis and treatment of macular degeneration are not effective for the majority of patients in whom late stage...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/S0361-9230(03)00072-8
更新日期：2004-02-15 00:00:00
abstract：:Taurine's site of action within the central nervous system was localized by studying its effect on prolactin secretion following the microinfusion of 125 nmoles of this amino acid into discrete regions of the brain. Taurine was found to stimulate prolactin secretion only when microinfused into the arcuate nucleus of t...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(84)90007-8
更新日期：1984-07-01 00:00:00
abstract：:Transnuclear transport of horseradish peroxidase (HRP) and wheat germ agglutinin-HRP conjugate (WGA-HRP) and the retrograde transport of fluorescent tracers were used to study axon collaterals of neurons in the mamillary nuclei. Tracers were injected into the thalamus or brain stem and after 18 hour-5 day survival per...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(85)90024-3
更新日期：1985-05-01 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a common neurological disease, causing severe disability and even deaths. Stem cell transplantation has been increasingly used in stroke therapy, and neural stem cells (NSCs) are a good source for stem cell transplantation. However, the regulatory mechanism of NSCs remains unclear. In...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.08.026
更新日期：2020-11-01 00:00:00
abstract：:The anticonvulsant drug Diazepam (DIA-2 mg/kg b. wt), the nitric oxide (NO) donor L-Arginine (L-Arg-2000 mg/kg b. wt) and the putative nitric oxide synthase (NOS) inhibitor N(G)-Nitro-L-Arginine methyl ester (L-NAME-50 mg/kg b. wt) were used to determine the role of endogenous NO on convulsions induced by picrotoxin (...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00011-8
更新日期：1999-03-01 00:00:00
abstract：:A combination of immunocytochemical, electrophysiological and pharmacological techniques were employed to study the properties of neurons within the supramammillary (SUM) complex of the rat. The SUM region contains a small, but dense, population of tyrosine hydroxylase immunoreactive neurons. Following injection of th...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(88)90060-3
更新日期：1988-03-01 00:00:00
abstract：:High-fat (HF) diet and obesity are risk factors for a number of mental health problems including depression, cognitive dysfunction, dementia, and neurodegenerative diseases. Histamine H1 receptors (H1Rs) are involved in many of these conditions. This study examined H1R receptor binding density in the brain of male rat...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2013.06.003
更新日期：2013-08-01 00:00:00
abstract：:Although interleukin-1β (IL-1β) is a prototypical pro-inflammatory cytokine, the specific mechanisms underlying the role of its cognate receptor, the interleukin-1 receptor (IL-1R) in peripheral sensitization remain to be investigated. Since emerging evidence in the literature indicates that IL-1β can modulate membran...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2017.01.019
更新日期：2017-04-01 00:00:00
abstract：:The development of central serotonergic neurons has been examined immunocytochemically utilizing an antiserum to serotonin (5-HT). Cells of the B4-B9 complex are first detected early on embryonic day 13 (E13; 7 mm crown rump length, CRL) and increase rapidly in number through E15 when they appear as bilateral columns ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90144-2
更新日期：1983-04-01 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression ar...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2008.12.002
更新日期：2009-03-30 00:00:00
abstract：:The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition in...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(98)00048-3
更新日期：1998-07-15 00:00:00
abstract：BACKGROUND AND PURPOSE:In humans, activation of the diving reflex by a cold stimulus to the face results in bradycardia, peripheral vasoconstriction and an increase in blood pressure. However, responses of the cerebral blood flow have not yet been evaluated. We undertook this study to assess the effect of cold face sti...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(03)00065-0
更新日期：2003-06-30 00:00:00
abstract：:The purpose of this study was to elucidate the role of norepinephrine (NE) in the mediation of adrenocortical responses following limbic stimuli. The effects of stimulation of the dorsal and ventral hippocampus and the midbrain reticular formation on the plasma corticosterone (CS) levels was studied in rats with vehic...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(88)90197-9
更新日期：1988-10-01 00:00:00
abstract：:Hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine (NIC) are sexually diergic: Female rats have higher adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses than do males. In the present study we determined HPA responses in male and female rats following single doses of NIC, a sing...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2011.03.001
更新日期：2011-05-30 00:00:00
abstract：:The localization and relative number of serotonergic (5HT) cell bodies in the brainstem of the cat were studied through the use of a specific immunocytochemical technique. A surprisingly large number of 5HT cells were found in regions in addition to the classical raphe nuclei (obscurus, pallidus, magnus, centralis sup...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(84)90003-0
更新日期：1984-07-01 00:00:00
abstract：:Bilateral inferior olive lesions, produced by systemic administration of the neurotoxin 3-acetylpyridine (3AP) produce a proconvulsant state specific for strychnine-induced seizures and myoclonus. We have proposed that these phenomena are mediated through increased excitation of cerebellar Purkinje cells, through acti...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90118-j
更新日期：1990-10-01 00:00:00
abstract：:The distribution of 125I-alpha-bungarotoxin (alpha-BTX), a putative nicotinic cholinergic receptor ligand was studied both in vitro and in vivo in the suprachiasmatic nucleus (SCN), anterior hypothalamic area (AHA), and supraoptic nucleus (SON) of the hypothalamus. For in vitro studies 20 micron frozen frontal section...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(86)90139-5
更新日期：1986-05-01 00:00:00
abstract：:The effect of the intracerebroventricular (ICV) administration of pertussis toxin on penile erection and yawning induced by apomorphine and oxytocin was studied in male rats. Pertussis toxin (2 micrograms ICV) prevented the above behavioral responses to apomorphine (80 micrograms/kg SC) and oxytocin (30 ng ICV) on day...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(92)90194-3
更新日期：1992-02-01 00:00:00
abstract：:The topographical distribution of cholinergic cell bodies has been studied in the rat brain and spinal cord by choline acetyltransferase (ChAT)-immunohistochemistry and acetylcholinesterase (AChE)-pharmacohistochemistry using diisopropylfluorophosphate (DFP). The ChAT-containing cells and the cells that stained intens...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90013-8
更新日期：1983-12-01 00:00:00
abstract：:After sustaining a traumatic brain injury (TBI), a person's ability to make daily decisions can be affected. Simple tasks such as, deciding what to wear are no longer effortless choices, but are instead difficult decisions. This study explored the use of a discrimination task with a magnesium treatment in order to exa...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2018.02.019
更新日期：2018-05-01 00:00:00
abstract：:Previous research has demonstrated that while primary visual cortex lesions in rats will disrupt performance of a learned brightness discrimination, the neural traces associated with this discrimination are spared. Moreover, the spared neural traces may, in certain instances, influence the postoperative reinstatement ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(78)90058-8
更新日期：1978-01-01 00:00:00
