Cellular mechanisms of peroxynitrite-induced neuronal death.

abstract：:A microdialysis probe, implanted in the posterior hypothalamus (PH) was used to examine changes of extracellular norepinephrine (NE) in freely moving rats from which mean arterial pressure (mAP) and heart rate (HR) were continuously monitored. Artificial cerebrospinal fluid (aCSF) was pumped through the probe and 10-m...

journal_title：Brain research bulletin

authors： Nakata T,Berard W,Kogosov E,Alexander N

更新日期：1990-10-01 00:00:00

abstract：:Although increasing evidence indicates that psychiatric symptoms are crucial characteristic of the early stage of Parkinson's disease (PD) and precede motor impairments, the neuronal firing activity of the basolateral nucleus of the amygdala (BLA) in the psychiatric symptom of PD and the involved mechanism are still u...

journal_title：Brain research bulletin

authors： Chen L,Liu J,Zhang QJ,Feng JJ,Gui ZH,Ali U,Wang Y,Fan LL,Hou C,Wang T

更新日期：2011-07-15 00:00:00

abstract：:A number of biological risk factors have been implicated for Alzheimer's disease (AD). The investigation of prevalence rates of AD in crosscultural populations has much potential in validating these factors. We previously assessed brain amyloid beta (A beta) protein deposition and other lesions associated with AD as p...

journal_title：Brain research bulletin

authors： Kalaria RN,Ogeng'o JA,Patel NB,Sayi JG,Kitinya JN,Chande HM,Matuja WB,Mtui EP,Kimani JK,Premkumar DR,Koss E,Gatere S,Friedland RP

更新日期：1997-01-01 00:00:00

abstract：:Diabetes mellitus (DM) is considered the primary cause of neuropathic pain. Osthole (7-methoxy-8[3-methylpent 2-enyl]coumarin) is a component extracted from Cnidium monnieri (L.) cusson plant seeds and has anti-inflammatory and anti-oxidative properties. The aim of the present study was to investigate the effects of o...

journal_title：Brain research bulletin

authors： Yuan H,Ouyang S,Yang R,Li S,Gong Y,Zou L,Jia T,Zhao S,Wu B,Yi Z,Liu H,Shi L,Li L,Gao Y,Li G,Xu H,Liu S,Zhang C,Liang S

更新日期：2018-09-01 00:00:00

abstract：:An evaluation of N,N-dipropargyl-2-phenylethylamine (DPGPEA) as a prodrug to increase brain levels of 2-phenylethylamine (PEA) was conducted in rats. A 0.1 mmol/kg (IP) dose of DPGPEA was administered and produced marked elevations of PEA levels in brain, liver and blood which were sustained for several hours. Ex vivo...

journal_title：Brain research bulletin

authors： Rao TS,Baker GB,Coutts RT

更新日期：1987-07-01 00:00:00

abstract：:The vertebrate neural tube consists of a series of neuromeres along its anteroposterior axis. Between amphioxus that possesses no neuromeres and gnathostomes, the lamprey occupies a critical position in the phylogeny for the origin of the segmented brain. To clarify the rhombomeric configuration of the Japanese lampre...

journal_title：Brain research bulletin

authors： Murakami Y,Ogasawara M,Satoh N,Sugahara F,Myojin M,Hirano S,Kuratani S

更新日期：2002-02-01 00:00:00

abstract：:Effects of the selective alpha 2-adrenoceptor agonist, medetomidine, on a compound volley of a tibial nerve stimulation-evoked spinal reflex, pain-induced phrenic motor responses and on postoperative neuropathic pain behavior were studied in rats. Medetomidine (0.3 mg/kg) decreased the amplitude of the compound volley...

journal_title：Brain research bulletin

authors： Taira T,Tanila H,Jyväsjärvi E,Pertovaara A,Kauppila T

更新日期：1995-01-01 00:00:00

abstract：:The catecholamines dopamine, epinephrine and norepinephrine, as well as the indoleamine serotonin were measured using radioenzymatic assays, in the frontal cortex of normal rats and of rats in which serotonin synthesis had been inhibited with p-chlorophenylalanine. Besides serotonin, norepinephrine levels were signifi...

journal_title：Brain research bulletin

authors： Reader TA

更新日期：1982-05-01 00:00:00

abstract：:In eleven acute precollicular rats, cortical and hippocampal EEG activity was recorded. Hippocampal theta activity of low frequency (mean 4.5 c/sec) was found in nine rats and in four occupied above 50% of the recording time. In contrast, in the cortex the synchronized EEG activity dominated. The electrical stimulatio...

journal_title：Brain research bulletin

authors： Gottesmann C,Gandolfo G,Zernicki B

更新日期：1989-06-01 00:00:00

abstract：:The antidepressant desipramine has been shown to decrease synaptic membrane concentrations of the norepinephrine re-uptake transporter (NET) in vivo and in vitro, on both an acute and a chronic basis. The possible contribution of decreased NET synthesis to the chronic downregulation of the NETs has not been definitive...

journal_title：Brain research bulletin

authors： Zavosh A,Schaefer J,Ferrel A,Figlewicz DP

更新日期：1999-07-01 00:00:00

abstract：:Windup, the frequency dependent build-up of spinal neuronal responses is an electrophysiological model of the development of the central sensitization in the chronic pain states. NR2B subunit containing NMDA-type glutamate receptors are implicated in the windup of dorsal horn neurons, while their role at the motoneuro...

journal_title：Brain research bulletin

authors： Kocsis P,Kovács G,Farkas S,Horváth C,Szombathelyi Z,Tarnawa I

更新日期：2004-08-30 00:00:00

abstract：:Gestational exposure to nicotine has been shown to interfere with biochemical markers of development of central and peripheral noradrenergic activity. The current study examines the development and function of cardiac beta-adrenergic receptors in the offspring of pregnant rats given nicotine infusions of 6 mg/kg/day f...

journal_title：Brain research bulletin

authors： Navarro HA,Mills E,Seidler FJ,Baker FE,Lappi SE,Tayyeb MI,Spencer JR,Slotkin TA

更新日期：1990-08-01 00:00:00

abstract：:The goal of this study was to determine if the dorsal noradrenergic bundle (DNAB) plays an essential role in mediating increased plasma renin activity (PRA) and hypothalamic activation, as indicated by increased Fos expression, in response to a small volume blood loss in unanesthetized animals. Male Sprague-Dawley rat...

journal_title：Brain research bulletin

authors： Jaworski RL,Blair ML

更新日期：2004-07-15 00:00:00

abstract：:Here we asked if insulin activation of the nucleus accumbens in vitro is reflected by an increase in (3)H-deoxyglucose ([(3)H]DG) uptake, thus subserving a new model to study molecular mechanisms of central insulin actions. Additionally, we investigated the dependence of this insulin effect on endocannabinoids and cor...

journal_title：Brain research bulletin

authors： Pinheiro BS,Lemos C,Neutzling Kaufmann F,Marques JM,da Silva-Santos CS,Carvalho E,Mackie K,Rodrigues RJ,Cunha RA,Köfalvi A

更新日期：2016-06-01 00:00:00

abstract：:The Lurcher (Lc/+) mutant mouse is characterized by a considerable atrophy of the cerebellum due to a massive loss of cerebellar Purkinje and granule cells, as well as of neurons from the inferior olivary nucleus. In this study the effects of a therapeutic combination of amantadine, thiamine and L-tryptophan on the se...

journal_title：Brain research bulletin

authors： Le Marec N,Hébert C,Botez MI,Botez-Marquard T,Marchand L,Reader TA

更新日期：1999-01-15 00:00:00

abstract：:Neonatal rats, when spinalized on the fourteenth postnatal day, showed minimal recovery of function in their hindlimbs. Bridging the cut spinal cord with E16 fetal spinal cord tissue did not improve functional recovery. Bridging, plus treatment with GM1 ganglioside, caused a significant (p less than 0.05) improvement ...

journal_title：Brain research bulletin

authors： Commissiong JW,Sauve Y,Csonka K,Karoum F,Toffano G

更新日期：1991-07-01 00:00:00

abstract：:Mouse models that replicate facets of human neurological diseases are often used at the pre-clinical stage to better understand the underlying mechanisms of a disease and test the target engagement of potential therapeutic interventions. We recently characterized a mouse model of childhood-onset parkinsonism-dystonia,...

journal_title：Brain research bulletin

authors： Giraldo G,Janus C

更新日期：2021-01-01 00:00:00

abstract：:We examined whether reticulospinal sympathoexcitatory neurons in the rostral ventrolateral medulla (RVLM) have muscarinic receptors and ACh inputs, and whether these cholinergic mechanisms on RVLM neurons are involved in the pressor response induced by peripheral administration of physostigmine. Microiontophoretic app...

journal_title：Brain research bulletin

authors： Kubo T,Taguchi K,Sawai N,Ozaki S,Hagiwara Y

更新日期：1997-01-01 00:00:00

abstract：:This study aims to evaluate the neuroprotective effect of sodium butyrate against the pentylenetetrazol (PTZ)-induced kindling epilepsy. Sodium butyrate (SB) (5, 10 and 20 mg/kg) and sodium valproate for 40 days and PTZ (37 mg/kg) injection every day were conducted for Kunming mice, to investigate seizure intensity an...

journal_title：Brain research bulletin

authors： Li D,Bai X,Jiang Y,Cheng Y

更新日期：2020-12-28 00:00:00

abstract：:Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain. However, insulin receptors are important for brain function...

journal_title：Brain research bulletin

authors： Mueller PL,Pritchett CE,Wiechman TN,Zharikov A,Hajnal A

更新日期：2018-10-01 00:00:00

abstract：:We have examined the effects of the presence of the mutated human presenilin 1 gene (M146L; hps1*) on lesion-induced sprouting in the hippocampus of the mouse (C57/CBA). The entorhinal cortex was unilaterally lesioned with ibotenic acid in adult, male mice. Four weeks later the subsequent axonal sprouting in the denta...

journal_title：Brain research bulletin

authors： Kadish I,Pradier L,van Groen T

更新日期：2002-03-15 00:00:00

abstract：:The use of neurons induced from stem cells has been introduced as an effective strategy for promoting peripheral nerve regeneration (PNR). The evolution and role of native denervated Schwann cells (SCs) were often ignored when exploring the mechanisms underlying neural transplantation therapy for PNR. The aim of this ...

journal_title：Brain research bulletin

authors： Zheng Y,Huang C,Liu F,Lin H,Niu Y,Yang X,Zhang Z

更新日期：2018-05-01 00:00:00

abstract：:Electrical stimulation has been shown to have neuroprotective effects on ganglion cells and photoreceptors in axotomized and dystrophic retinas from Royal College of Surgeons (RCS) rats. This study determined whether electrical stimulation also has a neuroprotective effect on cells in the inner nuclear layer (INL) of ...

journal_title：Brain research bulletin

authors： Schmid H,Herrmann T,Kohler K,Stett A

更新日期：2009-04-06 00:00:00

abstract：:Small GTPases of the rho family regulate the extensive rearrangements of the cytoskeleton that characterize neuronal differentiation. Citron kinase is a target molecule for activated rhoA, previously implicated in control of cytokinesis. We have found that, in addition, it could play an important role in modulating th...

journal_title：Brain research bulletin

authors： Di Cunto F,Ferrara L,Curtetti R,Imarisio S,Guazzone S,Broccoli V,Bulfone A,Altruda F,Vercelli A,Silengo L

更新日期：2003-05-30 00:00:00

abstract：:Observation of people performing movements facilitates motor planning, execution and memory formation. Tempo, a crucial aspect involved in the execution of rhythmic movements, is normally perceived and learned through auditory channels. In this work, we ascertained whether: first, the frequency of self-paced finger mo...

journal_title：Brain research bulletin

authors： Bove M,Tacchino A,Pelosin E,Moisello C,Abbruzzese G,Ghilardi MF

更新日期：2009-09-28 00:00:00

abstract：:In order to study mechanisms by which a neurotropic strain of influenza A virus (A/WSN/33) may affect neuronal function or cause nerve cell death, hippocampal cultures from embryonic rats were infected with this virus. Approximately 70% of the neurons in the infected cultures became immunopositive for viral antigens a...

journal_title：Brain research bulletin

authors： Brask J,Owe-Larsson B,Hill RH,Kristensson K

更新日期：2001-06-01 00:00:00

abstract：:The direct monosynaptic pathway which exists between vasoactive intestinal peptide (VIP) and GnRH neurons in the hypothalamic preoptic area provides a neuroanatomical background for the modulatory effects of VIP exerted on GnRH neurons activity. Though central microinjection of VIP revealed its involvement in the modu...

journal_title：Brain research bulletin

authors： Gajewska A,Wolińska-Witort E,Kochman K

更新日期：2005-10-30 00:00:00

abstract：:A method is described for the isolation and culture of neurons in the adult mammalian brain. The cell could be maintained in primary culture for more than several weeks. Whereas the neurons freshly dissociated from the adult brain did not respond to any of the neurotransmitter substances applied, the neurons regained ...

journal_title：Brain research bulletin

authors： Ogata N,Tatebayashi H

更新日期：1991-11-01 00:00:00

abstract：:Depression and anxiety have been reported as the major neuropsychiatric consequences following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms in patients with major depressive disorders and anxiety-like symptoms. In addition, minocycline demonstrated efficacy and seemed a promising neuro...

journal_title：Brain research bulletin

authors： Camargos QM,Silva BC,Silva DG,Toscano ECB,Oliveira BDS,Bellozi PMQ,Jardim BLO,Vieira ÉLM,de Oliveira ACP,Sousa LP,Teixeira AL,de Miranda AS,Rachid MA

更新日期：2020-02-01 00:00:00

abstract：:Wnt signaling plays an important role in the adult brain function and its dysregulation has been implicated in some neurodegenerative pathways. Despite the functional role of the Wnt signaling in adult neural circuits, there is currently no evidence regarding the relationships between exogenously Wnt signaling activat...

journal_title：Brain research bulletin

authors： Ortiz-Matamoros A,Arias C

更新日期：2018-05-01 00:00:00