Neuroprotective effect of transretinal electrical stimulation on neurons in the inner nuclear layer of the degenerated retina.

abstract：:The distribution of enkephalin-like cell bodies in the thalamus of the rat was studied by means of intratissular injections of colchicine and using an indirect immunoperoxidase technique. The densest clusters of immunoreactive perikarya were observed in the nuclei geniculatum lateralis ventralis, medialis dorsalis, ce...

journal_title：Brain research bulletin

authors： Coveñas R,Alonso JR,Conrath M

更新日期：1989-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a worldwide progressive neurodegenerative disorder in the elderly. Previous research has indicated that Alzheimer's disease impairs white matter (WM) tracts. Anatomical and neuroimaging studies have indicated that WM tracts are associated with cognitive function. Whether the abnormal WM int...

journal_title：Brain research bulletin

authors： Li Y,Feng F,Lin P,Huang ZG,Liu T,Zhou B,Yao H,Zheng L,Li C,Wang P,Zhang Z,Guo Y,Wang L,An N,Zhu X,Zhang X,Wang J

更新日期：2018-10-01 00:00:00

abstract：:The effect of subarachnoid hemorrhage (SAH) on the neuropeptides and mast cells of the rat dura mater has not been reported. We examined the outcome of SAH on the rat supratentorial dura mater to determine whether dural nerves undergo effects similar to those of nerves accompanying cerebral blood vessels after SAH. Fo...

journal_title：Brain research bulletin

authors： Keller JT,Mullen BG,Zuccarello M

更新日期：1993-01-01 00:00:00

abstract：:Locomotor activity was increased as a function of current intensity in a series of rats with chronic stimulating electrodes in the tegmental pedunculopontine nucleus. Single pulse stimulation of these same mesencephalic locomotor region (MLR) sites antidromically activated more than one-quarter of the neurons sampled ...

journal_title：Brain research bulletin

authors： Mogenson GJ,Wu M

更新日期：1986-03-01 00:00:00

abstract：:The glucostatic theory supports the role of central and peripheral substrate "sensors" in monitoring cellular glucose metabolism. Induction of hyperphagia and hyperglycemia by intracerebroventricular (i.c.v.) delivery of drugs inhibiting glucose uptake or oxidation suggests that glucose "sensors" are accessible from t...

journal_title：Brain research bulletin

authors： Briski KP

更新日期：2000-02-01 00:00:00

abstract：:Crested Ducks (CR) occasionally show intracranial fat bodies. Additionally, behavioral abnormalities such as motor incoordination can be observed. Here, it is shown that a behavioral test helps to identify CR that have a problematical fat body. The ducks were put on their backs, and the time required for them to stand...

journal_title：Brain research bulletin

authors： Cnotka J,Tiemann I,Frahm HD,Rehkämper G

更新日期：2008-06-15 00:00:00

abstract：:The present study investigated whether the raphe neurons which give rise to the transient serotonergic fibers in the visual cortex of neonatal rats persist or disappear as the rats mature. Three experiments were performed employing the WGA-apoHRP-Au retrograde transport technique in conjunction with 5-HT or WGA-HRP im...

journal_title：Brain research bulletin

authors： Koh T,Nakazawa M,Kani K,Maeda T

更新日期：1991-11-01 00:00:00

abstract：:Abnormalities of the ionotropic glutamate receptors (N-methyl-D-aspartate, alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid [AMPA], and kainate) have been reported in the brain in schizophrenia, although in complex, region-specific patterns. While limbic cortex and medial temporal lobe structures have been mo...

journal_title：Brain research bulletin

authors： Meador-Woodruff JH,Hogg AJ Jr,Smith RE

更新日期：2001-07-15 00:00:00

abstract：:Sex differences are prominent influences on spatial performance. One of the most common tasks to assess sex differences in spatial navigation in rodents is the Morris water task (MWT). In this task rats swim in a pool of water to locate a hidden platform employing the topographical relationships among the distal visua...

journal_title：Brain research bulletin

authors： Faraji J,Metz GA,Sutherland RJ

更新日期：2010-01-15 00:00:00

abstract：:Previous research has demonstrated that while primary visual cortex lesions in rats will disrupt performance of a learned brightness discrimination, the neural traces associated with this discrimination are spared. Moreover, the spared neural traces may, in certain instances, influence the postoperative reinstatement ...

journal_title：Brain research bulletin

authors： Levere TE,Davis N,Fontaine CW

更新日期：1978-01-01 00:00:00

abstract：:Serotonin 5-HT1A receptors belong to the superfamily of G-protein-coupled receptors. Receptor activation of G-proteins can be determined by agonist-stimulated [35S]GTPgammaS binding in the presence of excess GDP, and in vitro autoradiographic adaptation of this technique allows visualization of receptor-activated G-pr...

journal_title：Brain research bulletin

authors： Sim LJ,Xiao R,Childers SR

更新日期：1997-01-01 00:00:00

abstract：:Serotonergic modulation of acetylcholine (ACh) release after neuron-specific increase of the expression of 5-HT(1B) receptors by gene transfer was studied in vitro and in vivo. The increased expression of the 5-HT(1B) receptor in vitro was induced by treating rat primary fetal septal cell cultures for 3 days with a vi...

journal_title：Brain research bulletin

authors： Riegert C,Rothmaier AK,Leemhuis J,Sexton TJ,Neumaier JF,Cassel JC,Jackisch R

更新日期：2008-07-01 00:00:00

abstract：:Endocannabinoid system activity contributes to the homeostatic defense against aging and thus may counteract the progression of brain aging. The cannabinoid type 1 (CB1) receptor activity declines with aging in the brain, which impairs neuronal network integrity and cognitive functions. However, the underlying mechani...

journal_title：Brain research bulletin

authors： Kataoka K,Bilkei-Gorzo A,Nozaki C,Togo A,Nakamura K,Ohta K,Zimmer A,Asahi T

更新日期：2020-07-01 00:00:00

abstract：:This study was performed to elucidate the mechanism by which adenosine triphosphate (ATP) encapsulated into liposomes was able to protect against experimental brain ischemia in the rat. After intracarotidal administration of liposomally entrapped ATP, the ATP blood level increased dramatically whereas no change was ob...

journal_title：Brain research bulletin

authors： Chapat S,Frey V,Claperon N,Bouchaud C,Puisieux F,Couvreur P,Rossignol P,Delattre J

更新日期：1991-03-01 00:00:00

abstract：:Postmortem caudate and substantia nigra tissue samples from human parkinsonian patients (PD) and age-matched controls (NC) were analyzed for uric acid (UA), dopamine (DA), and ascorbic acid (AA) by HPLC/UV/ED. Uric acid and DA levels were significantly lower in the substantia nigra of PD by 54% and 85%, respectively. ...

journal_title：Brain research bulletin

authors： Church WH,Ward VL

更新日期：1994-01-01 00:00:00

abstract：:In the present study, cellular tropism and relative transduction efficiency of AAV2/6, AAV2/8 and AAV2/9 vectors have been tested for the cornea using primary cultures of human corneal fibroblasts. The AAV6, AAV8 and AAV9 serotypes having AAV2 ITR plasmid encoding for alkaline phosphatase (AP) gene were generated by t...

journal_title：Brain research bulletin

authors： Sharma A,Ghosh A,Hansen ET,Newman JM,Mohan RR

更新日期：2010-02-15 00:00:00

abstract：:Neurochemical and morphological effects of neonatal anoxia on monoamine systems were studied after 100% N2 exposure for 25 min at 30 h postnatally (postnatal day 2-P2). At 20 min after anoxia, reductions of tissue levels of cerebellar noradrenaline (NA) and striatal dopamine (DA) and metabolites were seen, while 5-hyd...

journal_title：Brain research bulletin

authors： Dell'Anna ME,Luthman J,Lindqvist E,Olson L

更新日期：1993-01-01 00:00:00

abstract：:The effect of regucalcin, a Ca(2+)-binding protein, on Ca(2+)-dependent protein kinase activity in the brain cytosol of rats with different ages (5 and 50 weeks old) was investigated. The addition of calmodulin (10 microg/ml) or dioctanoylglycerol (5 microg/ml) in the enzyme reaction mixture caused a significant incre...

journal_title：Brain research bulletin

authors： Hamano T,Hanahisa Y,Yamaguchi M

更新日期：1999-10-01 00:00:00

abstract：:Cerebral ischemia is one of the leading causes of death and long-term disability worldwide. N-myc downstream-regulated gene 4 (NDRG4) is predominantly expressed in the brain as well as in the heart and has been reported to be involved in resistance to neuronal cell death caused by ischemic injury. However, the underly...

journal_title：Brain research bulletin

authors： Wen L,Liu L,Li J,Tong L,Zhang K,Zhang Q,Li C

更新日期：2019-03-01 00:00:00

abstract：:Acute inflammation activates macrophages or monocytes and subsequently releases several inflammatory cytokines and reactive oxygen and nitrogen species. These proinflammatory cytokines activate astrocytes and trigger neurodegenerative diseases. In this work, we chose to address the mechanistic aspects of alpha-crystal...

journal_title：Brain research bulletin

authors： Masilamoni JG,Vignesh S,Kirubagaran R,Jesudason EP,Jayakumar R

更新日期：2005-10-15 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are promising donor cells for transplantation therapies for a variety of diseases. However, there still lack efficient ways to induce directional differentiation of BMSCs to promote their practical use in transplantation therapy. In this study, we constructed hybrid cells by transferr...

journal_title：Brain research bulletin

authors： Zhou Z,Xu Y,Zhong Q,Zheng J

更新日期：2012-02-10 00:00:00

abstract：:Our previous in vivo structure-activity studies suggested that the putative receptors mediating the effects of NPY and NPY2-36 on food intake and body temperature are pharmacologically different [17]. In the present study, we examined and compared dose-related effects of NPY and NPY2-36 on ad lib food intake and recta...

journal_title：Brain research bulletin

authors： Bouali SM,Fournier A,St-Pierre S,Jolicoeur FB

更新日期：1995-01-01 00:00:00

abstract：:The effects of two diketopiperazines, Cyclo (His-Pro) (CHP) and Cyclo (Asp-Phe) (CAP), on striatal extracellular levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) were examined using in vivo microdialysis in anaesthetized rats. Treatment with ...

journal_title：Brain research bulletin

authors： Kaakkola S,Wurtman RJ

更新日期：1993-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people over 60 years of age in the US and many other developed countries. Increasingly sophisticated methods for the diagnosis and treatment of macular degeneration are not effective for the majority of patients in whom late stage...

journal_title：Brain research bulletin

authors： Rowe-Rendleman C,Glickman RD

更新日期：2004-02-15 00:00:00

abstract：:Previous findings showed that inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), degrading enzymes of anandamide (2-AEA) and 2-arachidonoylglycerol (2-AG), reduced the nonsteroidal anti-inflammatory drug-induced gastric lesions. The present study aimed to investigate: i./whether centra...

journal_title：Brain research bulletin

authors： Tóth VE,Fehér Á,Németh J,Gyertyán I,Zádori ZS,Gyires K

更新日期：2018-05-01 00:00:00

abstract：:The inhibition of excitatory mechanisms by components of low molecular weight, isolated from spiders and solitary wasps, such as, the acyl-polyamines, has demonstrated, on the one hand, neuroprotection potential, and on the other hand, it is well known that some arthropod venom components have convulsant activity. Whi...

journal_title：Brain research bulletin

authors： Ribeiro AM,dos Santos WF,Garcia-Cairasco N

更新日期：2000-08-01 00:00:00

abstract：:Ongoing maternal behavior in rats is under the inhibitory influence of opiates. Exposure to drugs of abuse may result in a progressive and enduring enhancement of their reinforcing effects. Little attention has been paid to the possibility that puerperal treatment with morphine may lead to sensitization to this drug, ...

journal_title：Brain research bulletin

authors： Miranda-Paiva CM,Nasello AG,Yin AJ,Felicio LF

更新日期：2001-07-01 00:00:00

abstract：:Seizure activity stimulates adult neurogenesis, the birth of new neurons, in the hippocampus. Many new neurons that develop in the presence of repeatedly induced seizures acquire abnormal morphological and functional characteristics that can promote network hyperexcitability and hippocampal dysfunction. However, the i...

journal_title：Brain research bulletin

authors： Kalinina A,Maletta T,Carr J,Lehmann H,Fournier NM

更新日期：2019-10-01 00:00:00

abstract：:The in vitro and in vivo effects of alphaxalone, a steroid anesthetic, and two physiological steroids, tetrahydrodeoxycorticosterone (THDOC) and pregnenolone sulfate (PS), on GABAA receptor function were evaluated in long-sleep (LS) and short-sleep (SS) mice. In vitro, both alphaxalone and THDOC enhanced GABAergic inh...

journal_title：Brain research bulletin

authors： Bowers BJ,Wehner JM

更新日期：1992-07-01 00:00:00

abstract：:To determine whether repeated exposure of cocaine affects the dopaminergic innervation of the nucleus accumbens, we employed a typical cocaine-dosing regimen in adult male Sprague-Dawley rats followed by an immunocytochemical analysis of tyrosine hydroxylase (TH). Treatment consisted of bi-daily injections of saline o...

journal_title：Brain research bulletin

authors： Todtenkopf MS,De Leon KR,Stellar JR

更新日期：2000-07-15 00:00:00