Abstract:
:To determine whether repeated exposure of cocaine affects the dopaminergic innervation of the nucleus accumbens, we employed a typical cocaine-dosing regimen in adult male Sprague-Dawley rats followed by an immunocytochemical analysis of tyrosine hydroxylase (TH). Treatment consisted of bi-daily injections of saline or 15 mg/kg cocaine for 5 consecutive days. After 2 or 14 days of withdrawal, sections of the nucleus accumbens (NAc) were processed for tyrosine hydroxylase and the number of immunoreactive varicosities in the core and shell were quantified. Two days after treatment, the core demonstrated a decrease, while after 14 days of treatment, the shell was found to contain significantly more TH immunoreactive varicosities. Additionally, 2 days post-cocaine treatment, core-shell differences were found, however moderate differences were also found in the saline treatment group, making the absolute effects of cocaine difficult to separate from injection and handling effects at this time point. These results suggest that the shell of the NAc may undergo alterations that could be involved with behavioral sensitization that typically results from such cocaine treatment regimens.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Todtenkopf MS,De Leon KR,Stellar JRdoi
10.1016/s0361-9230(00)00277-xkeywords:
subject
Has Abstractpub_date
2000-07-15 00:00:00pages
407-11issue
5eissn
0361-9230issn
1873-2747pii
S0361-9230(00)00277-Xjournal_volume
52pub_type
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