Recovery of function in spinalized, neonatal rats.

abstract：:Accumulating evidence points to the amyloid-β (Aβ) peptide as the culprit in the pathogenesis of Alzheimer's disease (AD). β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is a protease that is responsible for initiating Aβ production. Although precise mechanisms that trigger Aβ accumulation remain unc...

journal_title：Brain research bulletin

authors： Ohno M

更新日期：2016-09-01 00:00:00

abstract：:Considerable evidence exists for an involvement of serotonergic mechanisms in the control of alcohol consumption. In the present study, an extensive 5-hydroxytryptamine (5-HT3) receptor autoradiographical investigation was performed using two genetically selected rat strains, alcohol preferring (P) and Alko alcohol (A...

journal_title：Brain research bulletin

authors： Ciccocioppo R,Ge J,Barnes NM,Cooper SJ

更新日期：1998-07-01 00:00:00

abstract：:The development of the lateral, basomedial and basolateral nuclei of the amygdala in 1-28 day old kittens was studied using Golgi morphometric methods. The major finding of this study is the growth of neurons within each of the nuclei of the amygdala examined occurs during the same time period, between 5-14 and 16-18 ...

journal_title：Brain research bulletin

authors： Wakefield CL,Levine MS

更新日期：1985-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a degenerative disease with a progressive loss of motor neurons in the central nervous system (CNS). However, there are unsolved problems with the therapies for this disease. α-Lipoic acid (LA) is a natural, universal antioxidant capable of scavenging hydroxyl radicals as well as...

journal_title：Brain research bulletin

authors： Wang T,Cheng J,Wang S,Wang X,Jiang H,Yang Y,Wang Y,Zhang C,Liang W,Feng H

更新日期：2018-06-01 00:00:00

abstract：:Adenoviral vector directed gene transfer to rat facial motoneurons occurs efficiently following intra-parenchymal injection of relatively high dosages (> or =10(7) pfu per injection) of a prototype first generation adenoviral vector. However, high level of transgene expression, as observed during the first week follow...

journal_title：Brain research bulletin

authors： Hermens WT,Verhaagen J

更新日期：1998-09-15 00:00:00

abstract：:It is now generally accepted that adenosine has a neuroprotective role in the central nervous system. Agonists of adenosine such as 2-chloroadenosine (2-ClA) have been shown to be neuroprotective, while antagonists such as 8-phenyltheophylline (8-PT) increase neurotoxicity. However, paradoxical results have been repor...

journal_title：Brain research bulletin

authors： Brooke SM,Sapolsky RM

更新日期：2000-03-01 00:00:00

abstract：:Various hypotheses are reviewed concerning the mechanisms of feeding induced by insulin or 2DG. New data are presented to show that elevated plasma ketone levels are not sufficient to suppress 2DG feeding, suggesting that nourishment of the brain either does not occur or is not sufficient to stop 2DG feeding. We find ...

journal_title：Brain research bulletin

authors： Rowland NE,Bellush LL,Carlton J

更新日期：1985-06-01 00:00:00

abstract：:Space motion sickness (SMS) and spatial orientation and motion perception disturbances occur in 70-80% of astronauts. People select "rest frames" to create the subjective sense of spatial orientation. In microgravity, the astronaut's rest frame may be based on visual scene polarity cues and on the internal head and bo...

journal_title：Brain research bulletin

authors： Harm DL,Parker DE,Reschke MF,Skinner NC

更新日期：1998-11-15 00:00:00

abstract：:Complex interactions between genetic and environmental factors exert a sustained influence on the pathogenesis of schizophrenia (SCZ). Adolescent social isolation is regarded as a typical paradigm for SCZ. However, the underlying pathological mechanisms are not fully understood. In this study, adolescent Sprague-Dawle...

journal_title：Brain research bulletin

authors： Sun L,Min L,Li M,Shao F,Wang W

更新日期：2018-09-01 00:00:00

abstract：:Vagal nerve stimulation (VNS) is known as an effective method of treatment in a number of neurological disorders. The low risk of side effects also makes it useful in clinical trials in other diseases. Branches of the vagal nerve innervate the anatomical structures known to be involved in memory processing. That is wh...

journal_title：Brain research bulletin

authors： Broncel A,Bocian R,Kłos-Wojtczak P,Kulbat-Warycha K,Konopacki J

更新日期：2020-02-01 00:00:00

abstract：:Regenerative medicine strategies rely on exogenous cell transplantation and/or endogenous cell stimulation. Biomaterials can help to increase the regenerative potential of cells and biomolecules by controlling transplanted cell fate and provide a local, sustained release of biomolecules. In this review, we describe th...

journal_title：Brain research bulletin

authors： Ho MT,Teal CJ,Shoichet MS

更新日期：2019-05-01 00:00:00

abstract：:The place conditioning paradigm has proven successful in identifying the neural mechanisms of drug reinforcement. Two classes of drugs, opiates and psychomotor stimulants, have received the most study, and in each case an important role for DA neurons of the mesolimbic system has been established. Moreover, both recep...

journal_title：Brain research bulletin

authors： Hoffman DC

更新日期：1989-10-01 00:00:00

abstract：:The olfactostriatum is a portion of the basal ganglia of snakes situated ventromedially to the nucleus accumbens proper. It receives a major vomeronasal input from the nucleus sphericus, the primary target of accessory olfactory bulb efferents. Recently, the ophidian olfactostriatum has been characterized on the basis...

journal_title：Brain research bulletin

authors： Martinez-Marcos A,Ubeda-Bañon I,Lanuza E,Halpern M

更新日期：2005-09-15 00:00:00

abstract：:The forebrain is characterized by a dense, localized dopamine (DA) innervation pattern, a diffuse, widespread norepinephrine (NE) innervation pattern, and a serotonin (5-HT) innervation intermediate between the DA and NE patterns. These innervation patterns have implied that basic differences exist in the way DA, NE a...

journal_title：Brain research bulletin

authors： Fallon JH,Loughlin SE

更新日期：1982-07-01 00:00:00

abstract：:Here we have investigated whether differences in levels of dopamine D1-like, D2-like receptors, dopamine D3 receptors, and dopamine transporter could be related to behaviors such as immobility response and locomotion between Wistar rats and Sprague-Dawley rats. The levels of the dopamine receptors and transporter were...

journal_title：Brain research bulletin

authors： Zamudio S,Fregoso T,Miranda A,De La Cruz F,Flores G

更新日期：2005-04-30 00:00:00

abstract：:Recent in vivo electrophysiological studies in our laboratory demonstrated medial thalamus (MT) induced short-term facilitation in the middle layers of the anterior cingulate cortex (ACC). The aim of the present study was to investigate different forms of short-term plasticity (STP) in layer II/III of the ACC in an in...

journal_title：Brain research bulletin

authors： Lee CM,Sylantyev S,Shyu BC

更新日期：2007-01-09 00:00:00

abstract：:It has been wildly accepted that willed movement(WM) training promotes neurological rehabilitation in patients with stroke. However, it was not clear whether the effect of WM is better than other forms of exercise. The purpose of this study is to assess different effects of WM and other forms of exercise on rats with ...

journal_title：Brain research bulletin

authors： Nie J,Yang X,Tang Q,Shen Q,Li S

更新日期：2016-01-01 00:00:00

abstract：:The effect of environmental odors emanating from large-scale hog operations on the mood of nearby residents was determined using the POMS (Profile of Mood States). The scores for six POMS factors and the TMD (total mood disturbance score) for 44 experimental subjects were compared to those of 44 control subjects who w...

journal_title：Brain research bulletin

authors： Schiffman SS,Miller EA,Suggs MS,Graham BG

更新日期：1995-01-01 00:00:00

abstract：:Trisomy of the whole or distal part of human chromosome 21 (HSA 21) (Ts21) results in Down Syndrome (DS), which is characterized in part by mental retardation and associated neurological abnormalities. Structural abnormalities observed frequently include reduced brain weight, decreased number and depth of sulci in the...

journal_title：Brain research bulletin

authors： Coyle JT,Oster-Granite ML,Gearhart JD

更新日期：1986-06-01 00:00:00

abstract：:Axons of retinal ganglion cells showed responses not previously emphasized: (a) many tonic units discharged oscillations, 2--12 spikes per burst, interburst intervals 20--300 msec; (b) phasic units showed concentric or flanking ON and OFF fields, response frequency depended on balance of retinal excitation and inhibit...

journal_title：Brain research bulletin

authors： O'Benar JD

更新日期：1976-11-01 00:00:00

abstract：:Electrical stimulation of the periaqueductal gray of the rat's midbrain analgesia leads to an increase in the number of artificial pulmonary metastases from the Walker 256 tumor. In an effort to investigate the influence of the pain suppression system and its associated peptides on this phenomenon, we activated the pa...

journal_title：Brain research bulletin

authors： Simon RH,Arbo TE,Lundy J

更新日期：1984-05-01 00:00:00

abstract：:Prenatal cocaine exposure increases mu-opioid receptor binding in dopaminergic terminal areas and enhances behavioral responsiveness to mu-opioid agonists. We investigated the influence of early postnatal cocaine treatment on in vitro mu- and delta-opioid receptor activation in male and female weanling rats. Pups rece...

journal_title：Brain research bulletin

authors： Meyer JS,Shani I,Rice D

更新日期：2000-09-15 00:00:00

abstract：:Administration of methionine enkephalin (ICV) to rats for 5 days resulted in the development of physical dependence as exemplified by a hypothermic response which peaked 2-8 hours after initiation of withdrawal. Twenty-four hours post-withdrawal, opioid receptor binding was determined in the striatum using a selective...

journal_title：Brain research bulletin

authors： Steece KA,DeLeon-Jones FA,Meyerson LR,Lee JM,Fields JZ,Ritzmann RF

更新日期：1986-08-01 00:00:00

abstract：:The purpose of this study was to determine whether elevated levels of 3,4-dihydroxyphenylacetic acid (DOPAC), the major metabolite of dopamine (DA) in the brain, could decrease the DA content in the striatum. Levels of DA were determined by high pressure liquid chromatography with electrochemical detection (HPLC-EC) i...

journal_title：Brain research bulletin

authors： Shiekhattar R,Ghasemzadeh MB,Adams RN

更新日期：1992-12-01 00:00:00

abstract：:Mouse models that replicate facets of human neurological diseases are often used at the pre-clinical stage to better understand the underlying mechanisms of a disease and test the target engagement of potential therapeutic interventions. We recently characterized a mouse model of childhood-onset parkinsonism-dystonia,...

journal_title：Brain research bulletin

authors： Giraldo G,Janus C

更新日期：2021-01-01 00:00:00

abstract：:Stimulation of the dorsal frontal cortex (area 10, FCtx) evoked two negative waves with short latencies (N1 and N2) followed by a large, longlasting positive wave (P) in the ventromedial nucleus (VMH) as well as in the more dorsal structures in the hypothalamus and the ventral thalamus. Since the N1 followed high freq...

journal_title：Brain research bulletin

authors： Ohta M,Oomura Y

更新日期：1979-03-01 00:00:00

abstract：:The influence of gender and stage of the estrous cycle on the levels of acetylcholine, serotonin, and noradrenaline in the hippocampus and on the susceptibility of the cholinergic septo-hippocampal pathway to the neurotoxic effect of ethylcholine aziridinium (AF64A) was investigated in the rat. Levels of acetylcholine...

journal_title：Brain research bulletin

authors： Hörtnagl H,Hansen L,Kindel G,Schneider B,el Tamer A,Hanin I

更新日期：1993-01-01 00:00:00

abstract：:The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition in...

journal_title：Brain research bulletin

authors： Kakinoki H,Ishizawa K,Fukunaga M,Fujii Y,Kamei C

更新日期：1998-07-15 00:00:00

abstract：:Parkinson's-diseased (PD) brains have been reported to contain increased quantities of iron within the zona compacta of the substantia nigra (SN). To test whether excess iron in the SN could cause a PD-like loss of dopaminergic neurons, various concentrations of iron were infused unilaterally within the SN of adult ma...

journal_title：Brain research bulletin

authors： Sengstock GJ,Olanow CW,Dunn AJ,Arendash GW

更新日期：1992-04-01 00:00:00

abstract：:Depression is a brain disorder and there is still only a partial understanding of its underlying pathophysiology. Antidepressant medications with a fast onset have not yet been developed. In addition to the monoaminergic systems, the brain glutaminergic system has been implicated in the etiology of depression. Animal ...

journal_title：Brain research bulletin

authors： Kovačević T,Skelin I,Minuzzi L,Rosa-Neto P,Diksic M

更新日期：2012-03-10 00:00:00