Antidepressant-like effects of insulin and IGF-1 are mediated by IGF-1 receptors in the brain.


:Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain. However, insulin receptors are important for brain function since insulin receptor knockout mice have depressive-like activity. Depression and cognitive problems are also associated with low insulin-like growth factor-1 (IGF-1) in the elderly. Rodent studies showed chronic IGF-1 administration had antidepressant-like (AD) activity. We asked if insulin in the brain might act through the IGF-1 receptor, as it does in some tissues. We used acute insulin or IGF-1 infusions into the 3rd ventricle (icv) in rats and tested animals in a forced swim test. We found that antidepressive-like behavior is mediated by insulin and IGF-1. Further, administration of the IGF-1 receptor antagonist JB-1 blocked the antidepressive-like activity of the insulin and IGF-1, indicating a strong relationship between insulin, IGF-1 and depression. Insulin acts at least partially through the IGF-1 receptor and is responsive to receptor antagonism. The model offers promise for future studies of the mechanism of depression, and therapy to increase insulin sensitivity and IGF-1 action including exercise and nutrition.


Brain Res Bull


Brain research bulletin


Mueller PL,Pritchett CE,Wiechman TN,Zharikov A,Hajnal A




Has Abstract


2018-10-01 00:00:00












  • Locus coeruleus stimulation modulates olfactory bulb evoked potentials.

    abstract::Field-evoked potentials from the main olfactory bulb in response to stimulation of the olfactory nerve and lateral olfactory tract were measured without and with conditioning stimulation of the locus coeruleus noradrenergic system. The locus coeruleus conditioning stimulus suppressed or inhibited the late components o...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Perez H,Hernandez A,Almli CR

    更新日期:1987-06-01 00:00:00

  • Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance.

    abstract::Rats were tested in the elevated plus-maze test of anxiety after a probe injection of chlordiazepoxide (CDP 5 mg/kg) following short-term (5 days) or long-term (20 days) pretreatment with 5 or 20 mg/kg/day. After short-term pretreatment with either dose, the probe dose had anxiolytic effects (it increased the % number...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: File SE,Baldwin HA,Aranko K

    更新日期:1987-11-01 00:00:00

  • What are the functions of fish brain pallium?

    abstract::There is some experimental evidence that the pallial areas of a fish's brain are involved in distincted learning functions. Recently published data suggest that the medial pallium is essential for avoidance learning and the lateral pallium is crucial for spatial learning and is also involved in temporal aspects of the...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Vargas JP,López JC,Portavella M

    更新日期:2009-08-14 00:00:00

  • Beta-endorphin injected into the nucleus of the raphe magnus facilitates metastatic tumor growth.

    abstract::Electrical stimulation of the periaqueductal gray of the rat's midbrain analgesia leads to an increase in the number of artificial pulmonary metastases from the Walker 256 tumor. In an effort to investigate the influence of the pain suppression system and its associated peptides on this phenomenon, we activated the pa...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Simon RH,Arbo TE,Lundy J

    更新日期:1984-05-01 00:00:00

  • Comparison of thalamic populations in mammals and birds: expression of ErbB4 mRNA.

    abstract::The expression of ErbB4 mRNA was examined in dorsal thalamic regions of chicks and rats. In rats, ErbB4 expression was observed in the habenular nuclei, the paraventricular nucleus, intermediodorsal nucleus, the central medial thalamic nucleus, the posterior nucleus, the parafascicular nucleus, the subparafascicular n...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Bruce LL,Kornblum HI,Seroogy KB

    更新日期:2002-02-01 00:00:00

  • Reduction of histamine H1 receptor binding induced by high-fat diet can be prevented by DHA and dietary fiber in specific brain areas of male rats.

    abstract::High-fat (HF) diet and obesity are risk factors for a number of mental health problems including depression, cognitive dysfunction, dementia, and neurodegenerative diseases. Histamine H1 receptors (H1Rs) are involved in many of these conditions. This study examined H1R receptor binding density in the brain of male rat...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Wu Z,Yu Y,Wu Y,Patch C,Szabo A,Huang XF

    更新日期:2013-08-01 00:00:00

  • Comparison of fractal and power spectral EEG features: effects of topography and sleep stages.

    abstract::Fractal nature of the human sleep EEG was revealed recently. In the literature there are some attempts to relate fractal features to spectral properties. However, a comprehensive assessment of the relationship between fractal and power spectral measures is still missing. Therefore, in the present study we investigated...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Weiss B,Clemens Z,Bódizs R,Halász P

    更新日期:2011-04-05 00:00:00

  • Exercise suppresses COX-2 pro-inflammatory pathway in vestibular migraine.

    abstract::Migraine and dizziness are relatively common disorders. Patients with dizziness have a higher incidence of migraines than the general population. The discomfort experienced by these patients is often poorly controlled by medication. However, the pathophysiology of vestibular migraine (VM) remains unclear. We hypothesi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Lee YY,Yang YP,Huang PI,Li WC,Huang MC,Kao CL,Chen YJ,Chen MT

    更新日期:2015-07-01 00:00:00

  • Distribution of substance P and enkephalin-like immunoreactivity in the substantia nigra of rat, cat and monkey.

    abstract::A comparative study of the distribution of substance P (SP) and enkephalin (ENK) immunoreactivity in the substantia nigra (SN) of the rat, cat and squirrel monkey (Saimiri sciureus) was undertaken by means of the indirect immunofluorescence technique. In the rat a dense neuronal network composed of fine fibers display...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Inagaki S,Parent A

    更新日期:1984-08-01 00:00:00

  • Morphine pretreatment increases opioid inhibitory effects on maternal behavior.

    abstract::Ongoing maternal behavior in rats is under the inhibitory influence of opiates. Exposure to drugs of abuse may result in a progressive and enduring enhancement of their reinforcing effects. Little attention has been paid to the possibility that puerperal treatment with morphine may lead to sensitization to this drug, ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Miranda-Paiva CM,Nasello AG,Yin AJ,Felicio LF

    更新日期:2001-07-01 00:00:00

  • High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin.

    abstract:BACKGROUND:Statins are cholesterol lowering drugs that decrease the risk of cardiovascular events, but they are related with a few unfavorable symptoms in skeletal muscle including myopathy, and mild to moderate fatigue. Additionally, there has been discrepancies about the impacts of statins on brain and cognition. Thi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Okudan N,Belviranli M

    更新日期:2020-12-01 00:00:00

  • Developmental disruptions and behavioral impairments in rats following in utero RNAi of Dyx1c1.

    abstract::Developmental malformations of cortex have been shown to co-occur with language, learning, and other cognitive deficits in humans. Rodent models have repeatedly shown that animals with such developmental malformations have deficits related to auditory processing and learning. More specifically, freeze-lesion induced m...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Threlkeld SW,McClure MM,Bai J,Wang Y,LoTurco JJ,Rosen GD,Fitch RH

    更新日期:2007-03-15 00:00:00

  • Effects of stimulus presentation rate on the activity of primary somatosensory cortex: a functional magnetic resonance imaging study in humans.

    abstract::To investigate the effect of stimulus presentation rate on the activity of primary somatosensory cortex, we performed echo-planar functional magnetic resonance imaging using a 1.5-tesla magnetic resonance system. Eight right-handed normal volunteers underwent functional magnetic resonance imaging during somatosensory ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Takanashi M,Abe K,Yanagihara T,Oshiro Y,Watanabe Y,Tanaka H,Hirabuki N,Nakamura H,Fujita N

    更新日期:2001-01-15 00:00:00

  • Regional distribution of beta-lipotropin converting enzymes in rat pituitary and brain.

    abstract::Among the brain areas studied only pars distalis and pars intermedia are found to contain beta-lipotropin activating enzyme indicating the these may be the exclusive organs for a physiologically significant conversion of beta-lipotropin into beta-endorphin. beta-Endorphin inactivating enzyme is found to be rather unif...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Kenessey A,Graf L

    更新日期:1977-07-01 00:00:00

  • Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B.

    abstract::The availability of mutant mice that lack either MAO A or MAO B has created unique profiles in the central and peripheral availability of serotonin, norepinephrine, dopamine, and phenylethylamine. This paper summarizes some of the current known phenotypic findings in MAO A knock-out mice and contrast these with those ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Holschneider DP,Chen K,Seif I,Shih JC

    更新日期:2001-11-15 00:00:00

  • Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.

    abstract::Aged (25-27 months) Long-Evans female rats were distinguished according to whether they showed no significant impairment (AU), moderate impairment (AMI), or severe impairment (ASI) in a spatial reference-memory task. Young (3-5 months) rats served as controls. Electrically evoked overflow of tritium was assessed in hi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Birthelmer A,Stemmelin J,Jackisch R,Cassel JC

    更新日期:2003-05-15 00:00:00

  • Projections from the pericruciate cortex to the nucleus of Darkschewitsch and other structures at the mesodiencephalic junction in the cat.

    abstract::After injecting a mixture of tritiated amino acids into various regions of the frontal cortices of cats, autoradiograms of the mesodiencephalic junctional region were processed. When the injections were placed in the lateral part of the motor area of the hand or arm regions, silver grains were manifested in the nucleu...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Nakamura Y,Kitao Y,Okoyama S

    更新日期:1983-04-01 00:00:00

  • Zinc release from Schaffer collaterals and its significance.

    abstract::On the basis of the evidence that approximately 45% of Schaffer collateral boutons are zinc-positive, zinc release from Schaffer collaterals and its action were examined in hippocampal slices. When zinc release from Schaffer collaterals was examined using ZnAF-2, a membrane-impermeable zinc indicator, ZnAF-2 signal in...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Takeda A,Nakajima S,Fuke S,Sakurada N,Minami A,Oku N

    更新日期:2006-02-15 00:00:00

  • Potent inhibitory input to locus coeruleus from the nucleus prepositus hypoglossi.

    abstract::Previous studies reported afferents to LC from the nucleus tractus solitarius (NTS), while more recent anatomic experiments indicate that the area of the nucleus prepositus hypoglossi (PrH), but not the NTS, provides robust innervation of LC. In the present experiments, the contribution of these two dorsomedial medull...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Ennis M,Aston-Jones G

    更新日期:1989-05-01 00:00:00

  • Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.

    abstract:OBJECTIVE:Parkinson's disease (PD) is a frequent degenerative disease of the nervous system with undefined pathogenesis. This study explored the protective effect of microRNA (miR)-218-5p on dopaminergic neuron injury in substantia nigra (SN) of rats with PD through the regulation of LIM and SH3 domain protein 1 (LASP1...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Ma X,Zhang H,Yin H,Geng S,Liu Y,Liu C,Zhao J,Liu Y,Wang X,Wang Y

    更新日期:2021-01-01 00:00:00

  • Relation between RNA content and ageing in neurons of the dorsal lateral geniculate nucleus.

    abstract::We carried out a study to establish ribonucleic acid (RNA) content in the nucleus and cytoplasm of single neuronal cells from the dorsal lateral geniculate nucleus (dLGN) of 3-30 month-old rats. Mean RNA content was calculated as the product of RNA concentration and nuclear or cytoplasmic surface. The analysis of neur...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Villena A,Díaz F,Chavarria I,Requena V,Peláez A,Pérez De Vargas I

    更新日期:1998-06-01 00:00:00

  • Blockade of stress-induced prolactin release in monosodium glutamate-treated rats.

    abstract::To elucidate the role of the medial basal hypothalamus (MBH) in stress-induced prolactin (Prl) release, adult male rats which had received monosodium glutamate (MSG 4 mg/g) on alternate days for the first 10 days of life were subjected to ether stress for 2 min. Blood samples were drawn at 0, 15, 30 and 60 min after e...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Mizunuma H,Khorram O,McCann SM

    更新日期:1983-01-01 00:00:00

  • Recovery of function in spinalized, neonatal rats.

    abstract::Neonatal rats, when spinalized on the fourteenth postnatal day, showed minimal recovery of function in their hindlimbs. Bridging the cut spinal cord with E16 fetal spinal cord tissue did not improve functional recovery. Bridging, plus treatment with GM1 ganglioside, caused a significant (p less than 0.05) improvement ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Commissiong JW,Sauve Y,Csonka K,Karoum F,Toffano G

    更新日期:1991-07-01 00:00:00

  • AMPA receptor antagonists, GYKI 52466 and NBQX, do not block the induction of long-term potentiation at therapeutically relevant concentrations.

    abstract::The involvement of alpha-amino-3-hydroxy-5-methylizoxazole-4-propionic acid (AMPA) receptors in induction of long-term potentiation (LTP) was examined in rat hippocampal slice preparation. Using conventional extracellular recording, excitatory postsynaptic potentials (EPSPs) and population action potentials (PSs), evo...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Kapus G,Székely JI,Durand J,Ruiz A,Tarnawa I

    更新日期:2000-08-01 00:00:00

  • Histoenzymological mapping of alkaline phosphatase and 5-nucleotidase in the medulla oblongata of a microchiropteran bat (Taphozous melanopogon Temminck).

    abstract::The contribution deals with the distribution of alkaline phosphatase and 5-nucleotidase in the medulla oblongata of Taphozous melanopogon (a Microchiroptera), for the first time. The main highlights of the study are: (1) Cranial nerve nuclei demonstrate intense activity of alkaline phosphatase, whereas except nucleus ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Hafiza B,Sood PP

    更新日期:1979-07-01 00:00:00

  • Asymmetry in the left and right habenulo-interpeduncular tracts in the frog.

    abstract::In the frog Rana esculenta the left dorsal habenula includes a lateral and a medial component, whereas the right dorsal habenula is only represented by one nucleus. The efferents of the habenular nuclei to the interpeduncular nucleus were herein investigated with the retrograde horseradish peroxidase tracing. Injectio...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Gugliemotti V,Fiorino L

    更新日期:1998-01-01 00:00:00

  • Sex differences in interhemispheric correlation and spectral power of EEG activity.

    abstract::EEG activity was recorded from left and right parietal cortex in adult male and female rats on a daily basis during 3 days. Absolute and relative power and interhemispheric correlation of the EEG activity were calculated and compared between males and females. Interhemispheric correlation of the theta rhythm was highe...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Juárez J,Corsi-Cabrera M

    更新日期:1995-01-01 00:00:00

  • Construction of a simple spike counter for analysis of electrophysiological recording data.

    abstract::A method for constructing a simple spike counter from a conventional calculator by taking advantage of the "adding display to memory" function [(M+) key] is described. The modification involves connecting the (M+) key to a dissecting pin and to a metallic notebook binder which is taped on to a transparent plastic shee...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Chan A,Dudley CA,Moss RL

    更新日期:1983-12-01 00:00:00

  • Misexpression of miR-196a induces eye anomaly in Xenopus laevis.

    abstract::miR-196a is located in the posterior trunk and plays a role in limb development. Here we show that miR-196a is able to induce eye anomaly in Xenopus laevis. Microinjection of synthetic miRNA precursor molecule for mammalian miR-196a into Xenopus embryo is sufficient for miR-196a overexpression during early development...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Qiu R,Liu Y,Wu JY,Liu K,Mo W,He R

    更新日期:2009-04-06 00:00:00

  • The "olfactostriatum" of snakes: a basal ganglia vomeronasal structure in tetrapods.

    abstract::The olfactostriatum is a portion of the basal ganglia of snakes situated ventromedially to the nucleus accumbens proper. It receives a major vomeronasal input from the nucleus sphericus, the primary target of accessory olfactory bulb efferents. Recently, the ophidian olfactostriatum has been characterized on the basis...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Martinez-Marcos A,Ubeda-Bañon I,Lanuza E,Halpern M

    更新日期:2005-09-15 00:00:00