Abstract:
:Neural progenitors in the subgranular zone of the hippocampal formation form a continuously proliferating cell population, generating new granule neurons throughout adult life. Between 10 days and 1 month after their formation, many of the newly generated cells die. The present study investigated whether a partial lesion of one of the main nuclei projecting to the hippocampus, the medial septum (MS), affects survival and differentiation of cells during this critical period. Rats were injected with BrdU and 5 days later excitotoxic lesion of the MS was applied by infusion of either 30 or 60 nmol of N-methyl-D-aspartate (NMDA). One week after the lesion, quantification of immunopositive cells revealed that the number of GABAergic cells was significantly reduced in both lesioned groups, whereas a decline in cholinergic cell number was observed only after injection of 60 nmol of NMDA. The partial septohippocampal denervation significantly reduced hippocampal neurogenesis. Survival of newly generated neurons was decreased by approximately 40%. The MS lesion did not affect proliferation of hippocampal progenitors. The present study points out the importance of a functional septohippocampal pathway for the regulation of hippocampal neurogenesis and highlights the potential role of GABA as a mediator in this phenomenon.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Van der Borght K,Mulder J,Keijser JN,Eggen BJ,Luiten PG,Van der Zee EAdoi
10.1016/j.brainresbull.2005.06.018keywords:
subject
Has Abstractpub_date
2005-09-30 00:00:00pages
117-25issue
1-2eissn
0361-9230issn
1873-2747pii
S0361-9230(05)00239-Xjournal_volume
67pub_type
杂志文章abstract::Neurobiotin and Lucifer yellow, indicators of gap junctional coupling, were applied to primary afferent fibers of the frog. Following application of tracers to cervical or lumbar dorsal root fibers, a large number of labeled granule cells were detected in the corpus cerebelli, the brainstem, and the spinal cord. The v...
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journal_title:Brain research bulletin
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:1977-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brainresbull.2006.10.014
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2021-01-10 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2004.12.007
更新日期:2005-03-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90047-0
更新日期:1988-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90019-6
更新日期:1988-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2012.06.008
更新日期:2012-10-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(87)90066-9
更新日期:1987-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90133-5
更新日期:1988-04-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2010.12.005
更新日期:2011-04-05 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1978-11-01 00:00:00