Abstract:
:Comparative studies on developmental gene expression suggest that the ancestral chordate central nervous system comprised anterior, midbrain-hindbrain boundary (MHB) and posterior regions. The most anterior region consists of both forebrain and midbrain in vertebrates. It remains, however, unresolved when or how the vertebrate midbrain was established from this anterior zone. I previously reported a mouse PRD-class homeobox gene, Dmbx1, expressed in the presumptive midbrain at early developmental stages, and in the hindbrain at later stages, with exclusion from the MHB. To investigate the evolution of midbrain development, I have cloned Dmbx genes from amphioxus and from Ciona, representing the two most closely related lineages to the vertebrates, and examined embryonic Dmbx expression in these species. In amphioxus, no Dmbx expression is observed in the neural tube, supporting previous arguments that the MHB equivalent region has been secondarily lost in evolution. In Ciona, the CiDmbx gene is detected in neural cells posterior to Pax-2/5/8-positive cells (MHB homologue), but not in any cells anterior to them. These results support the lack of a midbrain homologue in Ciona, and suggest that midbrain development is a vertebrate innovation. Here, I report the full sequences of these genes and discuss the evolution of midbrain development in relation to the tripartite neural ground plan and the origin of the MHB organizer.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Takahashi Tdoi
10.1016/j.brainresbull.2005.03.013keywords:
subject
Has Abstractpub_date
2005-09-15 00:00:00pages
510-7issue
4-6eissn
0361-9230issn
1873-2747pii
S0361-9230(05)00110-3journal_volume
66pub_type
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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doi:10.1016/0361-9230(81)90086-1
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(95)00081-o
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1990-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1981-10-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(86)90237-6
更新日期:1986-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(96)00138-4
更新日期:1996-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(87)90021-9
更新日期:1987-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90045-y
更新日期:1992-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.brainresbull.2009.07.003
更新日期:2009-09-28 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(97)00403-6
更新日期:1998-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(97)00115-9
更新日期:1997-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90036-1
更新日期:1989-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2004.03.009
更新日期:2004-07-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2019.03.003
更新日期:2019-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1984-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2013.12.001
更新日期:2014-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2017.03.003
更新日期:2018-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(86)90217-0
更新日期:1986-10-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(97)00339-0
更新日期:1998-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2016.05.010
更新日期:2016-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(95)00060-r
更新日期:1995-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90168-w
更新日期:1992-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2005.08.015
更新日期:2005-12-15 00:00:00