Abstract:
:In the unanesthetized cat, TRH was injected into the cerebral ventricles (ICV) through chronically implanted cannulae and the nature of the evoked salivation was investigated. TRH injected in doses from 0.1 to 1.0 mg evoked salivation which was not dose-dependent. The antimuscarinic drug atropine as well as the ganglionic blocking agent mecamylamine injected also ICV prevented the salivation induced by ICV TRH. On the other hand, virtually no effect on the TRH-salivation was induced by the following drugs injected ICV: alpha and the beta adrenergic blocking agents, yohimbine and propranolol; dopamine antagonist, chlorpromazine; 5-hydroxytryptamine antagonist, methysergide; and the antihistamine, antazoline. Further, in cats pretreated with ICV reserpine and 6-hydroxydopamine, but not with ICV 5,6-dihydroxytryptamine and hemicholinium, the salivation caused by ICV TRH was abolished. It is concluded that central cholinoceptive and catecholaminergic mechanisms are involved in the salivation induced by ICV TRH.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Beleslin DB,Jovanovic-Micic D,Tomic-Beleslin Ndoi
10.1016/0361-9230(87)90021-9subject
Has Abstractpub_date
1987-03-01 00:00:00pages
463-5issue
3eissn
0361-9230issn
1873-2747pii
0361-9230(87)90021-9journal_volume
18pub_type
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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