Abstract:
:The effects of transcranial magnetic stimulation (TMS), natalizumab (nata), dimethyl fumarate (DMF) and dexamethasone (DEX) on clinical score and oxidative stress produced by a single dose of myelin oligodendrocyte glycoprotein (MOG) in tail of Dark Agouti rats was studied. TMS (60Hz and 0.7 mT), nata (5mg/kg), DMF (15mg/kg) and DEX (300μg/kg) was applied for 21 after the administration of MOG (150μg). We estimated clinical score, as well as lipid peroxides, carbonylated proteins and reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio content in brain, spinal cord and blood. MOG triggered significant increase in clinical score and in the levels of lipid peroxides and carbonylated proteins levels, but reduced GSH/GSSG ratio in brain, spinal cord and blood. Both TMS and clinical treatments, although TMS more significantly, decreased the changes caused by MOG administration. These results support the antioxidant and neuroprotective action of TMS, as well as an activity higher than other clinical treatments.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Medina-Fernandez FJ,Escribano BM,Luque E,Caballero-Villarraso J,Gomez-Chaparro JL,Feijoo M,Garcia-Maceira FI,Pascual-Leone A,Drucker-Colin R,Tunez Idoi
10.1016/j.brainresbull.2017.11.018subject
Has Abstractpub_date
2018-03-01 00:00:00pages
140-145eissn
0361-9230issn
1873-2747pii
S0361-9230(17)30578-6journal_volume
137pub_type
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