Abstract:
:The primary objective of this study was to determine whether pretreatment with kappa- and delta-opioid agonists potentiates naltrexone-induced suppression of water consumption following 24h of deprivation. This study also examined the temporal effects of agonist-induced antinociception using the tail-flick and hot-plate tests. Adult male Sprague-Dawley rats were water deprived 20 h and then given an injection (s.c. or i.c.) of an opioid agonist or saline. Drugs included the mu-opioid agonists morphine and DAMGO ([d-Ala2,NMePhe4,Gly-ol5]-enkephalin), the kappa-opioid agonists spiradoline, bremazocine, and U69,593, and the delta-opioid agonists BW 373U86 and DPDPE ([D-Pen2, D-Pen5]-enkephalin). Three hours and forty-five minutes later, animals received a single dose of naltrexone (0.1-30 mg/kg, s.c.) or saline. Fifteen minutes later, animals were allowed free access to water for 30 min. For the tail-flick and hot-plate tests, animals were given a single injection of agonist and tested in both procedures every 30 min for up to 2h, then hourly up to 6h post-injection. Naltrexone dose-dependently suppressed fluid consumption 24h after deprivation. The effects of naltrexone on drinking were potentiated following pretreatment with at least one dose of the agonists tested except BW 373U86. With the exception of BW 373U86, DAMGO, and DPDPE, all of the opioid agonists produced significant antinociception in the hot-plate test. Only BW 373U86 failed to have an antinociceptive effect in the tail-flick test. By 4h after treatment, drug-induced antinociception had largely waned, suggesting the potentiation of naltrexone-induced drinking suppression was not a result of a direct interaction with the agonists. In conclusion, kappa-opioid and delta-opioid receptors appear to contribute to the manifestation of acute opioid dependence, albeit to a lesser degree than mu-opioid receptors.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
White DA,Ballard ME,Harmon AC,Holtzman SGdoi
10.1016/j.brainresbull.2008.04.002subject
Has Abstractpub_date
2008-08-15 00:00:00pages
597-604issue
6eissn
0361-9230issn
1873-2747pii
S0361-9230(08)00168-8journal_volume
76pub_type
杂志文章abstract::In eleven acute precollicular rats, cortical and hippocampal EEG activity was recorded. Hippocampal theta activity of low frequency (mean 4.5 c/sec) was found in nine rats and in four occupied above 50% of the recording time. In contrast, in the cortex the synchronized EEG activity dominated. The electrical stimulatio...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90006-3
更新日期:1989-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(79)90052-2
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2006.01.008
更新日期:2006-04-14 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(86)90037-7
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(98)00063-x
更新日期:1998-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.01.015
更新日期:2008-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00460-3
更新日期:2001-03-01 00:00:00
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journal_title:Brain research bulletin
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更新日期:1992-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(77)90038-7
更新日期:1977-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(82)90169-1
更新日期:1982-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(78)90014-x
更新日期:1978-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00601-3
更新日期:2001-10-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.11.009
更新日期:2012-02-10 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90165-x
更新日期:1983-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90021-3
更新日期:1994-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)00220-u
更新日期:1995-01-01 00:00:00
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更新日期:2010-01-15 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90215-j
更新日期:1992-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90075-0
更新日期:1989-02-01 00:00:00
abstract::In tests of corticosterone production in vitro, aqueous pineal homogenate (APH) modulates the effect of a short-chain ACTH analogue, ACTH 1-17, added to adrenals from different circadian stages. Adrenal and pineal glands from female B6D2F1 mice, standardized on staggered LD 12:12 regimens, were obtained at the same cl...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90060-6
更新日期:1983-07-01 00:00:00
abstract::The putative behavioral effects of the enantiomers of BAY K 8644 and the behavioral responses to (+/-)-BAY K 8644 following chronic injection were assessed on motor function in mice. The interaction of the enantiomers of BAY K 8644 with mouse brain dihydropyridine binding sites was also evaluated. The calcium channel ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90019-6
更新日期:1988-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90103-5
更新日期:1984-04-01 00:00:00
abstract::The effects of two diketopiperazines, Cyclo (His-Pro) (CHP) and Cyclo (Asp-Phe) (CAP), on striatal extracellular levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) were examined using in vivo microdialysis in anaesthetized rats. Treatment with ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90171-7
更新日期:1993-01-01 00:00:00
abstract::The effects of two indirect (dexfenfluramine and fluoxetine) and one direct (RU 24969) serotonergic agonists on diet selection over a 12-hr period were examined. Rats were habituated to eat, during the dark period, from two isoenergetic diets that differed in carbohydrate and protein content. Drugs were injected intra...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(90)90130-r
更新日期:1990-06-01 00:00:00
abstract::Scientific reports suggest that the exposure to long-term stressors throughout or during late gestation increase anxiety- and depression-like behaviors of offspring in their later life. Moreover, several studies concluded that increasing age correlates with increased anxiety behaviors in humans and rodents. In the pre...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.08.015
更新日期:2012-02-10 00:00:00
abstract::From a psychophysiological point of view, arousal is a fundamental feature of behavior. As reported in different empirical studies based on insights from theories of consumer behavior, store atmosphere should evoke phasic arousal reactions to attract consumers. Most of these empirical investigations used verbal scales...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2005.06.012
更新日期:2005-11-15 00:00:00