Abstract:
:The sources of noradrenergic (NA) innervation to the hypoglossal nucleus (nXII) in the rat were investigated with double-labeling histochemical/immunocytochemical and lesion/degeneration techniques. Following injection of wheat germ-agglutinin conjugated to horseradish peroxidase into nXII, brain stem sections were reacted with tetramethylbenzidine, stabilized, and incubated in antiserum to tyrosine hydroxylase (TH). Double-labeled neurons were observed in three pontine sites bilaterally, although mainly ipsilaterally, that included the nucleus subceruleus (nSC; 68.75%) and the A7 (21.09%) and A5 (10.15%) cell groups. Confirmation of the above results and identification of the course taken by descending NA-nXII projections was accomplished by lesioning the rostral pons, the nSC, or the medullary catecholamine bundle (MB), the suspected route by which NA afferents reach nXII. Quantitative estimates of the reduction of TH immunoreactivity on the lesioned compared to nonlesioned side of nXII were made densitometrically. In each case, TH immunostaining was significantly decreased (75%) in the ipsilateral caudoventromedial district of nXII, the predominant target area of NA input. The results from this study establish that multiple NA sources in the pons project to nXII in the rat, the majority of NA-nXII afferents are derived from the nSC, and descending NA-nXII projections course in the MB. These data are discussed relative to tongue control.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Aldes LD,Chapman ME,Chronister RB,Haycock JWdoi
10.1016/0361-9230(92)90168-wkeywords:
subject
Has Abstractpub_date
1992-12-01 00:00:00pages
931-42issue
6eissn
0361-9230issn
1873-2747pii
0361-9230(92)90168-Wjournal_volume
29pub_type
杂志文章abstract::Fetal mouse raphe and hippocampal tissue (from embryos with crown-rump length (CRL) 13-16 mm) was transplanted into adult and aged isogenetic mice to study the growth of serotonergic fibers between host and donor tissue. A specific antibody against serotonin (5-HT) was used to immunocytochemically visualize 5-HT conta...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(81)90122-2
更新日期:1981-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:2004-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2003-04-15 00:00:00
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journal_title:Brain research bulletin
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更新日期:2021-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/s0361-9230(97)00238-4
更新日期:1997-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1981-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.12.005
更新日期:2020-12-11 00:00:00
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journal_title:Brain research bulletin
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doi:10.1016/j.brainresbull.2009.01.012
更新日期:2009-04-29 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(78)90058-8
更新日期:1978-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(76)90081-2
更新日期:1976-11-01 00:00:00
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journal_title:Brain research bulletin
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更新日期:2001-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90036-1
更新日期:1989-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(80)90254-3
更新日期:1980-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90114-1
更新日期:1988-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90259-e
更新日期:1993-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2016.08.009
更新日期:2017-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90174-8
更新日期:1988-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90040-0
更新日期:1983-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.11.010
更新日期:2019-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(79)90289-2
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Traditional Medicine Practices (TMP) which are premised on indigenous knowledge and experiences within a local context of the culture and environment, are common place in low income countries. In Africa and in Uganda specifically, nearly 80% of the Ugandan population relies on TMP for the care of their menta...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2018.07.018
更新日期:2019-02-01 00:00:00
abstract::In alpha-chloralose-anesthetized Sprague-Dawley (SD) rats with unilateral nucleus tractus solitarius (NTS) lesions, injection of the alpha(1)-adrenergic receptor agonist phenylephrine into the contralateral NTS dose-dependently increased arterial pressure (AP). Bunazosin (0.1 nmol) or prazosin (0.36 nmol), an alpha(1)...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(02)00757-8
更新日期:2002-08-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2004.10.010
更新日期:2005-02-15 00:00:00
abstract::The role of alpha-2 adrenoceptors in the milk-ejection reflex was investigated by making electrophysiological recordings from oxytocin neurones in the supraoptic nucleus of urethane-anaesthetised rats. Systemic administration of the alpha-2 adrenoceptor antagonist. Idazoxan (0.5 mg/kg, i.v.), temporarily suppressed OT...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(97)00115-9
更新日期:1997-01-01 00:00:00
abstract::Traumatic spinal cord injury (SCI) can lead to motor disturbance, sensory deficit, or autonomic dysfunction. The role of circRNAs in the pivotal physiopathological processes of SCI has been demonstrated recently. However, no similar research has been performed to explore the circRNAs involved in apoptosis after SCI. T...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.08.004
更新日期:2020-11-01 00:00:00
abstract::Recent accounts of major depression have tended to focus on dysfunction of frontothalamic-striatal reentrant circuits as a possible source of the disorder. Evidence of frontostriatal involvement in unipolar major depression from lesion and neuropsychological studies, and functional and structural imaging studies is ex...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/s0361-9230(98)00126-9
更新日期:1998-11-01 00:00:00
abstract::Serotonin has been postulated to influence several developmental parameters. The potential role of serotonin in the development of the rat olfactory bulb, a simple cortical structure, was determined following selective depletion of serotonin to the olfactory bulb of neonate rats. In the neonate, 5,7-dHT was injected i...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90062-0
更新日期:1994-01-01 00:00:00