Biochemical markers for post-operative fatigue after major surgery.

abstract：:Nitric oxide (NO) is the main activator of the soluble guanylate cyclase (sGC)-guanosine 3'5' cyclic monophosphate (cGMP) pathway. The level of cGMP is regulated by phosphodiesterases (PDEs), which break down cGMP. It has been reported that levels of NO in the central nervous system (CNS) can greatly increase during d...

journal_title：Brain research bulletin

authors： Rapôso C,Luna RL,Nunes AK,Thomé R,Peixoto CA

更新日期：2014-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) constitutes a heterogeneous cerebral insult induced by traumatic biomechanical forces. Mitochondria play a critical role in brain bioenergetics, and TBI induces several consequences related with oxidative stress and excitotoxicity clearly demonstrated in different experimental model involv...

journal_title：Brain research bulletin

authors： Courtes AA,Gonçalves DF,Hartmann DD,da Rosa PC,Cassol G,Royes LFF,de Carvalho NR,Soares FAA

更新日期：2020-10-01 00:00:00

abstract：:The forebrain is characterized by a dense, localized dopamine (DA) innervation pattern, a diffuse, widespread norepinephrine (NE) innervation pattern, and a serotonin (5-HT) innervation intermediate between the DA and NE patterns. These innervation patterns have implied that basic differences exist in the way DA, NE a...

journal_title：Brain research bulletin

authors： Fallon JH,Loughlin SE

更新日期：1982-07-01 00:00:00

abstract：:The effects of unilateral and bilateral electrolytic lesions of the dorsal raphe nuclei (DRN) of 30-day-old rats, on the spontaneous and induced ovulation, were analyzed. The bilateral lesion and the lesion on the right side of the DRN delayed the age of first vaginal estrous. None of the animals with bilateral lesion...

journal_title：Brain research bulletin

authors： Ayala ME,Rosas P,Dominguez R

更新日期：1994-01-01 00:00:00

abstract：:Obesity and consumption of diet rich in fat are known to contribute to the development of Alzheimer's disease (AD) which is a complex and multifactorial neurodegenerative disease and a leading cause of mortality with unmet medical needs. Hypercholesterolemia was discovered to increase neuropathological changes along w...

journal_title：Brain research bulletin

authors： Zameer S,Alam M,Hussain S,Vohora D,Ali J,Najmi AK,Akhtar M

更新日期：2020-08-01 00:00:00

abstract：:It was found that neurons in the posterior orbitofrontal cortex, area 13, of the rhesus monkey were activated from self-stimulation electrodes (in 142 of 168 possible instances), and that neurons in the anterior orbitofrontal areas were much less likely to be activated from the self-stimulation electrodes (in only 28 ...

journal_title：Brain research bulletin

authors： Mora F,Avrith DB,Rolls ET

更新日期：1980-03-01 00:00:00

abstract：:There is growing evidence that Vitamin D(3) (1,25-dihydroxyvitamin D(3)) is involved in brain development. We have recently shown that the brains of newborn rats from Vitamin D(3) deficient dams were larger than controls, had increased cell proliferation, larger lateral ventricles, and reduced cortical thickness. Brai...

journal_title：Brain research bulletin

authors： Féron F,Burne TH,Brown J,Smith E,McGrath JJ,Mackay-Sim A,Eyles DW

更新日期：2005-03-15 00:00:00

abstract：OBJECTIVE:Parkinson's disease (PD) is a frequent degenerative disease of the nervous system with undefined pathogenesis. This study explored the protective effect of microRNA (miR)-218-5p on dopaminergic neuron injury in substantia nigra (SN) of rats with PD through the regulation of LIM and SH3 domain protein 1 (LASP1...

journal_title：Brain research bulletin

authors： Ma X,Zhang H,Yin H,Geng S,Liu Y,Liu C,Zhao J,Liu Y,Wang X,Wang Y

更新日期：2021-01-01 00:00:00

abstract：:The objective of this study was to determine the organization of coactivation in the arm and shoulder muscles. Normal human subjects made alternate movements of a joint in the horizontal plane, either adduction-abduction of the second finger and shoulder, ulnar-radial deviation of the wrist, or extension-flexion of th...

journal_title：Brain research bulletin

authors： Yamazaki Y,Suzuki M,Ohkuwa T,Itoh H

更新日期：2003-02-15 00:00:00

abstract：:The effects of two indirect (dexfenfluramine and fluoxetine) and one direct (RU 24969) serotonergic agonists on diet selection over a 12-hr period were examined. Rats were habituated to eat, during the dark period, from two isoenergetic diets that differed in carbohydrate and protein content. Drugs were injected intra...

journal_title：Brain research bulletin

authors： Luo SQ,Li ET

更新日期：1990-06-01 00:00:00

abstract：:Many similarities exist between the inhibitory influence of estrogen on food intake (FI) and body weight (BWt) in female rats and the effect of lateral hypothalamic (LH) lesions on energy balance. Thus, a possible interaction of small electrolytic LH lesions (0.8 mA/10 sec) with hormone-dependent changes in FI, BWt an...

journal_title：Brain research bulletin

authors： Nance DM,Gorski RA

更新日期：1978-09-01 00:00:00

abstract：:Entrainment of the dominant circadian pacemaker localised to the hypothalamic suprachiasmatic nuclei (SCN) is mediated partially via the indirect retino-geniculo-hypothalamic projection to the SCN, which is presumed to utilise enkephalin and other neurotransmitters, to modulate circadian rhythmicity. In the present st...

journal_title：Brain research bulletin

authors： Cutler DJ,Mundey MK,Mason R

更新日期：1999-09-15 00:00:00

abstract：:Groups of male Sprague-Dawley rats were predominantly fed either a high-fat or a high-carbohydrate (CHO) diet. For designated 2-day periods, their diets were switched. After baseline measurements of food and water intake, the rats were made diabetic by injections of either 40 or 46-50 mg/kg streptozotocin. Food and wa...

journal_title：Brain research bulletin

authors： Koopmans HS,Xavier Pi-Sunyer F

更新日期：1986-12-01 00:00:00

abstract：:Serotonin 5-HT1A receptors belong to the superfamily of G-protein-coupled receptors. Receptor activation of G-proteins can be determined by agonist-stimulated [35S]GTPgammaS binding in the presence of excess GDP, and in vitro autoradiographic adaptation of this technique allows visualization of receptor-activated G-pr...

journal_title：Brain research bulletin

authors： Sim LJ,Xiao R,Childers SR

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:To explore the unified and disease specific structural features of the brain in patients spanning six mental disorders who experience own-thought auditory verbal hallucinations (OTAVH). METHODS:A pilot study was conducted on 25 patients with schizophrenia (FUSCH-OTAVH), 20 patients with major depression diso...

journal_title：Brain research bulletin

authors： Zhuo C,Lin X,Wang C,Song X,Xu X,Li G,Xu Y,Tian H,Zhang Y,Wang W,Zhou C

更新日期：2020-07-01 00:00:00

abstract：:The effects of the peptide transmitter neurotensin (NT) on the release of acetylcholine (ACh), gamma-aminobutyric acid (GABA), glutamate (Glu), aspartate (Asp), and taurine from the prefrontal cortex (PFC) of freely moving rats were studied by transversal microdialysis. Neurotensin (0.2 and 1 microM) administered loca...

journal_title：Brain research bulletin

authors： Petkova-Kirova P,Rakovska A,Della Corte L,Zaekova G,Radomirov R,Mayer A

更新日期：2008-09-30 00:00:00

abstract：:The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson's disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging. However, the exact molecular mechani...

journal_title：Brain research bulletin

authors： Anandhan A,Jacome MS,Lei S,Hernandez-Franco P,Pappa A,Panayiotidis MI,Powers R,Franco R

更新日期：2017-07-01 00:00:00

abstract：:Over the last 15 years, many publications described the use of peptide sequences that have been dubbed cell penetrating peptides (CPP), Trojan Horse peptides, protein transduction domains, or membrane-translocating sequences. These mostly positively charged domains bring attached cargo across biological membranes. One...

journal_title：Brain research bulletin

authors： Dietz GP,Bähr M

更新日期：2005-12-15 00:00:00

abstract：:The issue of possible neurobiological effects of the electromagnetic field (EMF) exposure is highly controversial. To determine whether electromagnetic field exposure could act as an environmental stimulus capable of producing stress responses, we employed the hippocampus, a sensitive target of electromagnetic radiati...

journal_title：Brain research bulletin

authors： Yang XS,He GL,Hao YT,Xiao Y,Chen CH,Zhang GB,Yu ZP

更新日期：2012-07-01 00:00:00

abstract：:We have studied the effects of 14-methoxymetopon (HS 198), a potent opioid agonist, on the responses to the tail electric stimulation test and plus-maze activity of adult male rats. The prototype mu agonist morphine was used as the drug of reference. Besides we addressed the effects of HS 198 on the serum corticostero...

journal_title：Brain research bulletin

authors： Urigüen L,Fernández B,Romero EM,De Pedro N,Delgado MJ,Guaza C,Schmidhammer H,Viveros MP

更新日期：2002-03-15 00:00:00

abstract：:In the present study, multi-electrode array recording was used to examine dorsal horn activity following stimulation of primary afferents in a rat dorsal root attached-spinal cord slice preparation. The multi-electrode array probe was placed under the dorsal horn slice and local field potentials evoked by stimulation ...

journal_title：Brain research bulletin

authors： Yu F,Zhao ZY,He T,Yu YQ,Li Z,Chen J

更新日期：2017-05-01 00:00:00

abstract：:Neural progenitors in the subgranular zone of the hippocampal formation form a continuously proliferating cell population, generating new granule neurons throughout adult life. Between 10 days and 1 month after their formation, many of the newly generated cells die. The present study investigated whether a partial les...

journal_title：Brain research bulletin

authors： Van der Borght K,Mulder J,Keijser JN,Eggen BJ,Luiten PG,Van der Zee EA

更新日期：2005-09-30 00:00:00

abstract：:In recent years, increasing number of data indicate that cerebral structures exert a direct, pituitary-independent, neural regulatory action on the endocrine glands. In addition, both experimental and clinical observations indicate functional asymmetry of the control system. Therefore, the objective of the present stu...

journal_title：Brain research bulletin

authors： Banczerowski P,Csaba Z,Csernus V,Gerendai I

更新日期：2000-09-15 00:00:00

abstract：:Fetal mouse raphe and hippocampal tissue (from embryos with crown-rump length (CRL) 13-16 mm) was transplanted into adult and aged isogenetic mice to study the growth of serotonergic fibers between host and donor tissue. A specific antibody against serotonin (5-HT) was used to immunocytochemically visualize 5-HT conta...

journal_title：Brain research bulletin

authors： Azmitia EC,Perlow MJ,Brennan MJ,Lauder JM

更新日期：1981-12-01 00:00:00

abstract：:We quantitated the activity of ornithine decarboxylase (ODC) in homogenates and subcellular fractions of inner ear tissues from the rat and guinea pig and demonstrate inhibition of cochlear ODC by the aminoglycoside neomycin. Subcellular fractionation showed the enzyme associated with the post-mitochondrial supernatan...

journal_title：Brain research bulletin

authors： Henley CM 3rd,Gerhardt HJ,Schacht J

更新日期：1987-12-01 00:00:00

abstract：:We examined whether reticulospinal sympathoexcitatory neurons in the rostral ventrolateral medulla (RVLM) have muscarinic receptors and ACh inputs, and whether these cholinergic mechanisms on RVLM neurons are involved in the pressor response induced by peripheral administration of physostigmine. Microiontophoretic app...

journal_title：Brain research bulletin

authors： Kubo T,Taguchi K,Sawai N,Ozaki S,Hagiwara Y

更新日期：1997-01-01 00:00:00

abstract：:The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to...

journal_title：Brain research bulletin

authors： Wilkins HM,Swerdlow RH

更新日期：2017-07-01 00:00:00

abstract：:Depression and anxiety have been reported as the major neuropsychiatric consequences following stroke. Minocycline, a neuroprotective drug has minimized depressive symptoms in patients with major depressive disorders and anxiety-like symptoms. In addition, minocycline demonstrated efficacy and seemed a promising neuro...

journal_title：Brain research bulletin

authors： Camargos QM,Silva BC,Silva DG,Toscano ECB,Oliveira BDS,Bellozi PMQ,Jardim BLO,Vieira ÉLM,de Oliveira ACP,Sousa LP,Teixeira AL,de Miranda AS,Rachid MA

更新日期：2020-02-01 00:00:00

abstract：:Songbirds have emerged as extremely important animals for investigating sex steroid hormone effects on the central nervous system. The masculinizing effects of exogenous estrogen on the neural circuits controlling song in female zebra finches are well documented. There is evidence that estrogens are necessary for the ...

journal_title：Brain research bulletin

authors： Schlinger BA

更新日期：1997-01-01 00:00:00

abstract：:The neuropathology of Alzheimer disease is characterized by senile plaques, neurofibrillary tangles and cell death. These hallmarks develop according to the differential vulnerability of brain networks, senile plaques accumulating preferentially in the associative cortical areas and neurofibrillary tangles in the ento...

journal_title：Brain research bulletin

authors： Savioz A,Leuba G,Vallet PG,Walzer C

更新日期：2009-10-28 00:00:00