Abstract：
:The effects of the peptide transmitter neurotensin (NT) on the release of acetylcholine (ACh), gamma-aminobutyric acid (GABA), glutamate (Glu), aspartate (Asp), and taurine from the prefrontal cortex (PFC) of freely moving rats were studied by transversal microdialysis. Neurotensin (0.2 and 1 microM) administered locally in the PFC produced a concentration-dependent increase in the extracellular levels of ACh, GABA, and Asp, but not of Glu or taurine. The increase produced by 1 microM NT reached a maximum of about 240% for ACh, 370% for GABA, and 380% for Asp. Lower doses of NT (0.05 microM) did not cause a significant change in ACh, GABA, or Asp output in the PFC. Higher concentrations of NT (2 microM) did not induce further increases in the level of neurotransmitters. A high-affinity selective neurotensin receptor (NTR1) antagonist SR 48692 (0.5 microM) perfused locally blocked neurotensin (1 microM)-evoked ACh, GABA, and Asp release. Local infusion of the sodium channel blocker tetrodotoxin (TTX) (1 microM) decreased the release of ACh, had no significant effect on GABA or Asp release, and prevented the 1 microM neurotensin-induced increase in ACh, GABA, and Asp output. Removal of calcium from the Ringer's solution prevented the peptide from having any effects on the neurotransmitters. Thus, in vivo NT plays a modulatory role in the PFC by interacting with cortical neurons releasing GABA and Asp and with ACh-containing neurons projecting to the PFC. The NT effects are of neural origin, as they are TTX-sensitive, and mediated by the NTR1 receptor, as they are antagonized by SR 48692.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Petkova-Kirova P,Rakovska A,Della Corte L,Zaekova G,Radomirov R,Mayer Adoi
10.1016/j.brainresbull.2008.04.003subject
Has Abstractpub_date
2008-09-30 00:00:00pages
129-35issue
2-3eissn
0361-9230issn
1873-2747pii
S0361-9230(08)00169-Xjournal_volume
77pub_type
杂志文章abstract：:The antinociceptive response of mice to the amino acid L-arginine (L-ARG) has been attributed to either an opioid mechanism or a non-opioid but nitric oxide (NO)-dependent mechanism. Earlier it was reported that the mechanism of nitrous oxide-induced antinociception involved opioid components and was also dependent on...
journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2002-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：1978-11-01 00:00:00
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pub_type： 杂志文章
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更新日期：1992-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0361-9230(01)00678-5
更新日期：2002-02-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2016.04.003
更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(89)90058-0
更新日期：1989-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0361-9230(81)80021-4
更新日期：1981-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2016.01.008
更新日期：2016-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(93)90030-f
更新日期：1993-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(81)90102-7
更新日期：1981-07-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2018.08.009
更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1998-08-01 00:00:00
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更新日期：2007-03-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(94)90202-x
更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2009-01-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(89)90075-0
更新日期：1989-02-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(80)90167-7
更新日期：1980-05-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1986-05-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(85)90149-2
更新日期：1985-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2016.10.004
更新日期：2017-03-01 00:00:00
abstract：:Reserpine depletes dopamine (DA) levels and increases tyrosine hydroxylase (TH) activity in the rat corpus striatum. TH is activated not only by enhancement of DA neuronal impulse flow, but also by cessation of impulse flow. To assist in the understanding of the relative contribution of impulse flow to the regulation ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(81)80037-8
更新日期：1981-02-01 00:00:00
abstract：:In the present study we investigated the effect of electrolytic lesion of the medial septal area (MSA) on the pressor and dipsogenic response to cholinergic activation and angiotensin II (ANGII) injection into the subfornical organ (SFO) in rats. In addition the effect of MSA lesion on the natriuresis, kaliuresis and ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90191-0
更新日期：1994-01-01 00:00:00
