Abstract:
:The effects of ACTH4-10, a peptide fragment of corticotropin, on rat dorsal root ganglia (DRG), spinal cord and sciatic nerve were studied following a crush lesion of the sciatic nerve. The in vitro total protein synthesis rate of DRG L4, L5 and L6, measured one and three days after ipsilateral nerve crush, were not altered by various ACTH4-10 treatment regimes. Likewise, neither ACTH4-10 treatment of sham-operated rats nor in vitro exposure of control ganglia to peptide, resulted in changes in synthesis rate. Four days after crush lesion, the amounts of actin and tubulin in the ventral horn L2-L5 region of the spinal cord and of actin in DRG L5 were estimated following 2-dimensional separation. No significant effect of ACTH treatment was found. Degeneration-associated changes in the protein profiles of segments of sciatic nerve were not altered by ACTH4-10 treatment. The data are discussed in relation to the possible site of action of neurotrophic ACTH-like peptides.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Edwards PM,Verhaagen J,Spierings T,Schotman P,Jennekens FG,Gispen WHdoi
10.1016/0361-9230(85)90149-2subject
Has Abstractpub_date
1985-09-01 00:00:00pages
267-72issue
3eissn
0361-9230issn
1873-2747pii
0361-9230(85)90149-2journal_volume
15pub_type
杂志文章abstract::The effects of intrathecally (i.t.) administered naloxone or glibenclamide, a blocker of adenosine triphosphate-sensitive potassium (KATP) channels, on the antinociception produced by i.t. apomorphine were observed by an integrated electromyogram measurement of hindlimb flexor reflex in lightly pentobarbital-anestheti...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(99)00002-7
更新日期:1999-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:2003-01-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90071-5
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更新日期:1994-01-01 00:00:00
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journal_title:Brain research bulletin
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doi:10.1016/j.brainresbull.2005.01.009
更新日期:2005-04-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90219-a
更新日期:1991-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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更新日期:1999-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(76)90043-5
更新日期:1976-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-04-14 00:00:00
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pub_type: 杂志文章
doi:10.1016/0361-9230(95)02142-6
更新日期:1996-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2015.06.005
更新日期:2015-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(83)90181-8
更新日期:1983-08-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2003.12.001
更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1984-10-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1016/0361-9230(85)90209-6
更新日期:1985-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1986-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.07.004
更新日期:2008-10-22 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/s0361-9230(97)00238-4
更新日期:1997-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.04.002
更新日期:2008-08-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)90230-5
更新日期:1994-01-01 00:00:00
abstract::Neonatal rats, when spinalized on the fourteenth postnatal day, showed minimal recovery of function in their hindlimbs. Bridging the cut spinal cord with E16 fetal spinal cord tissue did not improve functional recovery. Bridging, plus treatment with GM1 ganglioside, caused a significant (p less than 0.05) improvement ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90272-l
更新日期:1991-07-01 00:00:00
abstract::The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 18...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90038-y
更新日期:1992-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(82)90184-8
更新日期:1982-07-01 00:00:00
abstract::The function of the phasic dopamine signal, seen in response to salient and rewarding stimuli, has been heavily debated. The reward prediction error hypothesis has been criticised for the suggestion that such a complex signal could be derived at short latencies, relying only on subcortical inputs. However, as more has...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2006.08.010
更新日期:2006-12-11 00:00:00