Abstract:
:In the present study we investigated the effect of electrolytic lesion of the medial septal area (MSA) on the pressor and dipsogenic response to cholinergic activation and angiotensin II (ANGII) injection into the subfornical organ (SFO) in rats. In addition the effect of MSA lesion on the natriuresis, kaliuresis and diuresis after cholinergic activation of the SFO was also investigated. Sham- and MSA-lesioned rats with a stainless steel cannula implanted into the SFO was used. The injection of ANGII (12 ng) into the SFO in sham rats produced pressor (24 +/- 2 mmHg) and dipsogenic (9.6 +/- 1.1 ml/h) responses. MSA lesion, both acute (2-6 days) and chronic (15-19 days), reduced the pressor (14 +/- 2 mmHg) and dipsogenic (2.7 +/- 1 ml/h) responses to ANGII into SFO. The injection of the cholinergic agonist carbachol (2 nmol) into the SFO in sham rats produced pressor (48 +/- 4 mmHg), dipsogenic (10 +/- 1.2 ml/h), natriuretic (457 +/- 58 microEq/2 h) and kaliuretic (249 +/- 16 microEq/2 h) responses. Acute, but not chronic MSA lesion reduced the pressor (27 +/- 3 mmHg), natriuretic (198 +/- 55 microEq/2 h) and kaliuretic (128 +/- 16 microEq/2 h) responses to carbachol into SFO. No change in the dipsogenic response to carbachol into the SFO was observed in MSA-lesioned rats. Antidiuresis after carbachol was observed only in MSA-lesioned rats. The present results show that the MSA plays a role on the pressor, natriuretic and kaliuretic responses to cholinergic activation of the SFO in rats and on the pressor and dipsogenic responses to ANGII into the same area.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Colombari DS,Haibara AS,Camargo LA,Saad WA,Renzi A,DeLuca LA Jr,Menani JVdoi
10.1016/0361-9230(94)90191-0subject
Has Abstractpub_date
1994-01-01 00:00:00pages
249-54issue
3eissn
0361-9230issn
1873-2747pii
0361-9230(94)90191-0journal_volume
33pub_type
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