Abstract:
:A continuous rhythmic discharge in the subthalamic nucleus (STN), lateral habenular nucleus, and ventral tegmental area (VTA) is associated with tremor in cats lightly anesthetized with barbiturate. The pontine raphe nuclei centralis superior and inferior also show barbiturate dependent slow wave and unitary activity. Stimulation of the raphe region produces evoked potentials and synchronization of the oscillatory activity in STN and VTA. The latency of the evoked response is shortest in STN. Extensive raphe lesions abolish the rhythmic activity in STN and VTA, but lesions which do not completely destroy nuclei centralis superior and inferior are not effective. In single cell recordings 81% of 142 cells in the pontine raphe region and medial reticular formation are inhibited following VTA stimulation. Fifty-four percent of 129 cells in the same region were inhibited when tested with STN stimulation. Forty-seven raphe paramedian reticular formation cells showed convergence of inhibitory input from STN, VTA, and contralateral sciatic nerve (Group II and III fibers). Depletion of serotonin with rho-chlorophenylalanine did not affect the appearance of barbiturate rhythmic activity. It is concluded that the pontine raphe region is not essential for maintenance of the oscillatory activity in STN and VTA, and that the raphe region is on the output side of the system.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Sutin J,Tsubokawa T,McBride Rdoi
10.1016/0361-9230(76)90053-8subject
Has Abstractpub_date
1976-01-01 00:00:00pages
93-102issue
1eissn
0361-9230issn
1873-2747pii
0361-9230(76)90053-8journal_volume
1pub_type
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journal_title:Brain research bulletin
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brain research bulletin
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更新日期:2004-03-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1992-02-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1976-05-01 00:00:00
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更新日期:2000-03-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(91)90125-4
更新日期:1991-09-01 00:00:00
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pub_type: 杂志文章,评审
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