Abstract：
:Our previous results showed that neurochemical destruction of the amygdaloid terminal field of the mesolimbic dopaminergic system caused disturbances in body weight regulation and feeding. In the present experiments, it was studied whether 6-hydroxydopamine (6-OHDA)-induced bilateral lesions of the mesolimbic dopaminergic system in the lateral preoptic area produce similar symptoms in rats. To enhance the selectivity of the neurotoxin, 6-OHDA was also used after desmethylimipramine (DMI) premedication. Both 6-OHDA and 6-OHDA + DMI treatments resulted in hypophagia, hypodipsia and body weight decrease. A significant increase of water intake was found in sham-operated controls and lesioned animals, in response to extracellular dehydration caused by polyethylene glycol. Intracellular dehydration induced by hypertonic saline resulted in increase of water intake of all animals; however, 6-OHDA- and 6-OHDA + DMI-treated rats drank less than the controls. Similar observation has been made when food intakes were compared after 2-deoxy-D-glucose treatment. Results show that mesolimbic dopaminergic elements play an essential role in the regulation of feeding.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Lénárd L,Karádi Z,Jandó G,Yoshimatsu H,Hajnal A,Sándor P,Oomura Ydoi
10.1016/0361-9230(91)90125-4subject
Has Abstractpub_date
1991-09-01 00:00:00pages
359-65issue
3-4eissn
0361-9230issn
1873-2747pii
0361-9230(91)90125-4journal_volume
27pub_type
杂志文章abstract：:The present study was conducted to evaluate plasma levels of monoamine neurotransmitter metabolites in spontaneous recurrences of methamphetamine psychosis (i.e., flashbacks). The subjects were 50 physically healthy females comprised of 25 who experienced flashbacks (flashbackers), 18 who did not experienced methamphe...
journal_title：Brain research bulletin
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-01-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2017-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1980-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：1977-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2000-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：1984-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-11-20 00:00:00
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pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(95)00081-o
更新日期：1995-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.01.011
更新日期：2004-04-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0361-9230(03)00065-0
更新日期：2003-06-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/s0361-9230(97)00458-9
更新日期：1998-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(86)90237-6
更新日期：1986-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(94)90230-5
更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1978-03-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1993-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.06.002
更新日期：2004-08-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.09.020
更新日期：2009-03-30 00:00:00
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pub_type： 杂志文章
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更新日期：1981-02-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2010-01-15 00:00:00
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pub_type： 杂志文章
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更新日期：2018-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-03-15 00:00:00
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pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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更新日期：2020-12-01 00:00:00
