Role of intraamygdaloid acylated-ghrelin in spatial learning.

Abstract:

:According to recently published papers acylated-ghrelin (A-Ghr) modifies memory and learning. The basolateral nucleus of amygdala (ABL) participates in the regulation of memory and learning mechanisms. Previously we verified A-Ghr responsive neurons in the ABL by electrophysiological methods. In male Wistar rats effects of bilateral intraamygdaloid microinfusion of 50 ng, 100 ng A-Ghr, 15 ng Ghr receptor antagonist d-Lys3-GHRP-6 (ANT) or ANT+50 ng A-Ghr [dissolved in 0.15M sterile saline], or vehicle in 0.4 microl volume were investigated in Morris water maze paradigm. 50 ng A-Ghr significantly reduced latency to find the platform located in one of the quadrants of the maze. Effect of 50 ng A-Ghr was blocked by ANT pretreatment. ANT alone had no effect. Our results show that place learning linked memory processes are facilitated by A-Ghr in the rat ABL. It is a specific effect, because it could be eliminated by ANT pretreatment.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Tóth K,László K,Lénárd L

doi

10.1016/j.brainresbull.2009.10.003

subject

Has Abstract

pub_date

2010-01-15 00:00:00

pages

33-7

issue

1

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(09)00318-9

journal_volume

81

pub_type

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