Abstract：
:The thiol reagent cysteamine was administered to adult male rats with the aim of investigating its effect on different neural and pineal components. As expected, immunoreactive somatostatin decreased in the median eminence (ME) (p less than 0.05) and gastric antrum (p less than 0.05) after cysteamine; however, no significant change was observed in the pineal IRS content after drug treatment. A decrease in norepinephrine was observed in the ME (p less than 0.001), hypothalamus (p less than 0.001) and pineal gland (p less than 0.05), together with a rise in ME (p less than 0.005) and hypothalamic dopamine (p less than 0.005) content; these results are consistent with a dopamine-beta-hydroxylase inhibiting effect of cysteamine. No effect was observed on hypothalamic serotonin and 5-hydroxyindole-acetic acid content. Pineal N-acetyltransferase (NAT) activity was significantly higher (p less than 0.05) after cysteamine than after saline, but no statistically significant effect was observed on pineal melatonin content. The mechanism involved in the NAT rise is presumably not related to the known stimulatory effect of norepinephrine, which fell after cysteamine. It is suggested that cysteamine may act at an intracellular level, inhibiting NAT degradation, an effect demonstrated in vitro and thought to be related to a thiol:disulfide exchange mechanism.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Webb SM,Champney TH,Steger RW,Vaughan MK,Reiter RJdoi
10.1016/0361-9230(86)90051-1subject
Has Abstractpub_date
1986-03-01 00:00:00pages
315-20issue
3eissn
0361-9230issn
1873-2747pii
0361-9230(86)90051-1journal_volume
16pub_type
杂志文章abstract：:Preprodynorphin and preproenkephalin are protein precursors from which are derived two classes of opioid neurotransmitter peptides. Dynorphin A((1-17)) is produced by proteolytic processing of prodynorphin, and processing of proenkephalin yields the enkephalin peptides. We report here on the isolation and sequencing o...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2004.01.008
更新日期：2004-03-15 00:00:00
abstract：:Recent investigations of the nucleus ambiguus (NA) have attempted to identify motoneurons associated with the branchiomeric muscles of the larynx and pharynx. However, relatively little attention has been directed to the levator veli palatini muscle (LVP) which is critical in respiration, deglutition and eustachian tu...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(83)90165-x
更新日期：1983-09-01 00:00:00
abstract：:Various hypotheses are reviewed concerning the mechanisms of feeding induced by insulin or 2DG. New data are presented to show that elevated plasma ketone levels are not sufficient to suppress 2DG feeding, suggesting that nourishment of the brain either does not occur or is not sufficient to stop 2DG feeding. We find ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(85)90111-x
更新日期：1985-06-01 00:00:00
abstract：:The forebrain is characterized by a dense, localized dopamine (DA) innervation pattern, a diffuse, widespread norepinephrine (NE) innervation pattern, and a serotonin (5-HT) innervation intermediate between the DA and NE patterns. These innervation patterns have implied that basic differences exist in the way DA, NE a...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(82)90143-5
更新日期：1982-07-01 00:00:00
abstract：:Recent findings in epigenetics shed new light on the regulation of gene expression in the central nervous system (CNS) during stress. The most frequently studied epigenetic mechanisms are DNA methylation, histone modifications and microRNA activity. These mechanisms stably determine cell phenotype but can also be resp...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2013.07.003
更新日期：2013-09-01 00:00:00
abstract：:To compare the developmental pattern of the visual tecto- and thalamofugal pathways in the altricial pigeon, we examined the posthatch differentiation of the retinothalamic system. Choleratoxin was injected into the left and right eye to visualize the retinal innervation pattern of the lateral geniculate nucleus of th...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.10.036
更新日期：2008-03-18 00:00:00
abstract：:Intrathecal grafting of cells as biological pumps to deliver monoamines, endorphins, and/or trophic factors, has been shown to be effective in treating chronic pain both in experimental animals and in clinical trials. We have tested whether intrathecal implantation of neuroblastoma cells reduces heat hyperalgesia and ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(02)00867-5
更新日期：2002-11-30 00:00:00
abstract：:The effects of two indirect (dexfenfluramine and fluoxetine) and one direct (RU 24969) serotonergic agonists on diet selection over a 12-hr period were examined. Rats were habituated to eat, during the dark period, from two isoenergetic diets that differed in carbohydrate and protein content. Drugs were injected intra...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90130-r
更新日期：1990-06-01 00:00:00
abstract：:Recent studies demonstrate that activation of Ca(2+)-permeable N-methyl-D-aspartate (NMDA) receptors upregulates phosphorylation of mitogen-activated protein kinases (MAPKs) in heterologous cells and neurons. In cultured rat striatal neurons, the present work systematically evaluated the role of a number of protein ki...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2008.11.004
更新日期：2009-03-30 00:00:00
abstract：OBJECTIVE:Cerebral ischemic stroke (IS) threatens the daily life of individuals, with high mortality. Emerging studies have deciphered the independent roles of the long non-coding RNA growth-arrest-specific transcript 5 (GAS5), microRNA (miR)-455-5p and phosphatase and tensin homolog (PTEN) in IS, but the understanding...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2020.12.002
更新日期：2021-02-01 00:00:00
abstract：:Three models of inducing spinal trauma in experimental animals--weight-dropping model, severance-by-knife model, and laceration-type-lesions model--are reviewed critically. Contributions by these models in understanding paraplegia in anatomical and pathological terms are brought out. Important distinctions between sub...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/0361-9230(89)90123-8
更新日期：1989-01-01 00:00:00
abstract：:The morphological interactions between astroglial and neuronal elements were elucidated in the rat suprachiasmatic nucleus (SCN) by light and electron microscopic immunocytochemistry using antibodies against glial fibrillary acidic protein (GFAP), vasoactive intestinal peptide (VIP) and arginine-vasopressin (AVP). Thr...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(97)00403-6
更新日期：1998-01-01 00:00:00
abstract：:The topographical distribution of glutamate uptake, GABA uptake, and GAD activity was studied in caudal, intermediate and rostral areas of the nucleus of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the of the solitary tract (NTS), dorsal motor nucleus of the vagus (DMN) and the hypoglossal nu...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(85)90176-5
更新日期：1985-01-01 00:00:00
abstract：:Behavioral abnormalities have been reported in young and adult animals exposed to benzodiazepines prenatally. The presence of neurochemical alterations in the GABAergic system after prenatal benzodiazepine exposure was assessed in a chick model which avoids prenatal and postnatal maternal effects. The GABAA receptor c...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(89)90143-3
更新日期：1989-09-01 00:00:00
abstract：:Retinal injuries and diseases are major causes of human disability involving vision impairment by the progressive and permanent loss of retinal neurons. During development, assembly of this tissue entails a successive and overlapping, signal-regulated engagement of complex events that include proliferation of progenit...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2018.10.016
更新日期：2019-09-01 00:00:00
abstract：:Corticotropin-releasing factor (CRF) is the major neuromodulator of the hypothalamic-pituitary-adrenal axis, regulating the behavioural, endocrine, autonomic and immune responses to stress. Together with the recently discovered members of the CRF peptide family, urocortin 1, urocortin 2 and urocortin 3, it also has ne...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.07.003
更新日期：2008-01-31 00:00:00
abstract：:We celebrate in 1998 the centenary of the discovery of the Golgi apparatus. Neurones have played a special role in the history of this cell organelle, primarily because the endocellular apparatus was discovered in nerve cells by Camillo Golgi when he was studying the cerebellum of an owl. In the following years, the a...
journal_title：Brain research bulletin
pub_type： 传,历史文章,杂志文章,评审
doi：10.1016/s0361-9230(98)00080-x
更新日期：1998-10-01 00:00:00
abstract：:Single units were recorded bilaterally from the caudate nuclei of cats before and after 50 microliter injections of either Merlis solution or L-DOPA (200 microgram) dissolved in Merlis into the left lateral cerebral ventricle. After injection of L-DOPA, but not Merlis solution, there was a period of unit silence in bo...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(77)90083-1
更新日期：1977-07-01 00:00:00
abstract：:Levels of serotonin were measureed in microdissected, individual brain nuclei in ovariectomized rats after treatment with ovarian hormones. Regions sampled included nuclei in the forebrain, rostral and medial hypothalamus, and midbrain tegmentum. Estradiol benzoate decreased levels of luteinizing hormone in plasma but...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(79)90044-3
更新日期：1979-07-01 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a devastating subtype of stroke because it has few viable therapeutic options to intervene against primary or second brain injury. Recently, evidence has suggested that ferroptosis, a nonapoptotic form of cell death, is involved in ICH. In this study, we examined whether ICH-induced n...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2019.08.013
更新日期：2019-11-01 00:00:00
abstract：:After sustaining a traumatic brain injury (TBI), a person's ability to make daily decisions can be affected. Simple tasks such as, deciding what to wear are no longer effortless choices, but are instead difficult decisions. This study explored the use of a discrimination task with a magnesium treatment in order to exa...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2018.02.019
更新日期：2018-05-01 00:00:00
abstract：:The purpose of this study was to elucidate the role of norepinephrine (NE) in the mediation of adrenocortical responses following limbic stimuli. The effects of stimulation of the dorsal and ventral hippocampus and the midbrain reticular formation on the plasma corticosterone (CS) levels was studied in rats with vehic...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(88)90197-9
更新日期：1988-10-01 00:00:00
abstract：:In rats, on the 25th day after the start of a thiamine-deficient (TD) diet, impairment of avoidance learning was significantly induced in proportion to the decrease somatostatin (SST) fluorescence intensity in the cortex, amygdala, thalamus, hypothalamus, and hippocampus, including the CA1, CA2, and dentate gyrus (DG)...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00201-4
更新日期：2000-01-01 00:00:00
abstract：:Simultaneous blood and cerebrospinal fluid (CSF) samples were taken from conscious sheep before, during and after parturition. Concentrations of plasma and CSF oxytocin were significantly elevated during contractions and particularly at birth. Mean prepartum CSF concentrations of oxytocin were around 55% of those foun...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90178-m
更新日期：1991-05-01 00:00:00
abstract：:The effect of serotonin synthesis inhibitor, p-chlorophenylalanine (PCPA), on induction and maintenance of pseudopregnancy as indicated by deciduoma formation was examined in female rats. Animals were injected with 1 mg/kg b.wt. of reserpine on the day of metestrus, and silk thread was passed through and placed in the...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(95)02117-5
更新日期：1996-01-01 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease and is clinically characterised by the death of corticospinal motor neurons (CSMNs), spinal and brainstem MNs and the degeneration of the corticospinal tract. Degeneration of CSMNs and MNs leads inexorably to muscle wastage and weakness, ...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2018.05.023
更新日期：2018-06-01 00:00:00
abstract：:The vertebrate neural tube consists of a series of neuromeres along its anteroposterior axis. Between amphioxus that possesses no neuromeres and gnathostomes, the lamprey occupies a critical position in the phylogeny for the origin of the segmented brain. To clarify the rhombomeric configuration of the Japanese lampre...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/s0361-9230(01)00669-4
更新日期：2002-02-01 00:00:00
abstract：:Hoe 065 is a compound structurally related to the angiotensin converting enzyme inhibitors and capable of increasing central cholinergic activity. The effects of this compound were studied on alcohol intake and on the reduction in alcohol intake produced by abutapril, an angiotensin converting enzyme inhibitor. Hoe 06...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90104-r
更新日期：1991-04-01 00:00:00
abstract：:Autophagy is the lysosome-mediated bulk degradation of cellular components for material recycling to maintain cellular homeostasis. Autophagy was initially regarded as a nonselective process, however, recent evidence indicates that this process can in fact be highly selective, especially for targeting and degrading or...
journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2017.11.009
更新日期：2018-03-01 00:00:00
abstract：:Somatostatin immunoreactive (SOM-I) perikarya were first observed in the ventral horn at E12, in the presumptive intermediate gray area at E14, and in the alar plate of the rostral spinal cord at E14. In general, after their initial appearance, their density increased and then decreased during development. A moderate ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(88)90125-6
更新日期：1988-07-01 00:00:00
