Perspectives in anatomy and pathology of paraplegia in experimental animals.

Abstract:

:Three models of inducing spinal trauma in experimental animals--weight-dropping model, severance-by-knife model, and laceration-type-lesions model--are reviewed critically. Contributions by these models in understanding paraplegia in anatomical and pathological terms are brought out. Important distinctions between subthreshold traumas vs. threshold and suprathreshold traumas, transient and permanent paraplegic syndrome, and regeneration of served axonal fibers vs. prevention of development of permanent paraplegia, are stressed while evaluating each model of spinal trauma. Conceptual contributions by these three models and their bearing on the potential clinical applications are discussed.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Das GD

doi

10.1016/0361-9230(89)90123-8

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

7-32

issue

1

eissn

0361-9230

issn

1873-2747

pii

0361-9230(89)90123-8

journal_volume

22

pub_type

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