Perspectives in anatomy and pathology of paraplegia in experimental animals.


:Three models of inducing spinal trauma in experimental animals--weight-dropping model, severance-by-knife model, and laceration-type-lesions model--are reviewed critically. Contributions by these models in understanding paraplegia in anatomical and pathological terms are brought out. Important distinctions between subthreshold traumas vs. threshold and suprathreshold traumas, transient and permanent paraplegic syndrome, and regeneration of served axonal fibers vs. prevention of development of permanent paraplegia, are stressed while evaluating each model of spinal trauma. Conceptual contributions by these three models and their bearing on the potential clinical applications are discussed.


Brain Res Bull


Brain research bulletin


Das GD




Has Abstract


1989-01-01 00:00:00














  • Microarray assay of circular RNAs reveals cicRNA.7079 as a new anti-apoptotic molecule in spinal cord injury in mice.

    abstract::Traumatic spinal cord injury (SCI) can lead to motor disturbance, sensory deficit, or autonomic dysfunction. The role of circRNAs in the pivotal physiopathological processes of SCI has been demonstrated recently. However, no similar research has been performed to explore the circRNAs involved in apoptosis after SCI. T...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Yao Y,Wang J,He T,Li H,Hu J,Zheng M,Ding Y,Chen YY,Shen Y,Wang LL,Zhu Y

    更新日期:2020-11-01 00:00:00

  • Progesterone receptor isoforms expression in the prepuberal and adult male rat brain.

    abstract::Progesterone receptor (PR) isoforms expression was determined in several regions of the prepuberal and adult male rat brain by using reverse transcription coupled to polymerase chain reaction. Rats under a 14:10-h light-dark cycle, with lights on at 0600 h were used. We found that in the hypothalamus of prepuberal ani...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Guerra-Araiza C,Reyna-Neyra A,Salazar AM,Cerbón MA,Morimoto S,Camacho-Arroyo I

    更新日期:2001-01-01 00:00:00

  • Atorvastatin attenuates the antinociceptive tolerance of morphine via nitric oxide dependent pathway in male mice.

    abstract::The development of morphine-induced antinociceptive tolerance limits its therapeutic efficacy in pain management. Atorvastatin, or competitive inhibitor of 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase, is mainstay agent in hypercholesterolemia treatment. Beyond the cholesterol-lowering activity, exploratio...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Hassanipour M,Amini-Khoei H,Shafaroodi H,Shirzadian A,Rahimi N,Imran-Khan M,Rezayat SM,Dehpour A

    更新日期:2016-07-01 00:00:00

  • A narrative analysis of the link between modern medicine and traditional medicine in Africa: a case of mental health in Uganda.

    abstract:BACKGROUND:Traditional Medicine Practices (TMP) which are premised on indigenous knowledge and experiences within a local context of the culture and environment, are common place in low income countries. In Africa and in Uganda specifically, nearly 80% of the Ugandan population relies on TMP for the care of their menta...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Abbo C,Odokonyero R,Ovuga E

    更新日期:2019-02-01 00:00:00

  • Increased vasopressinergic activity following DOCA administration in the rat.

    abstract::The dynamics of hypothalamic arginine vasopressin (AVP) release was examined during the development of hypertension in rats with deoxycorticosterone (DOCA)-NaCL induced hypertension. Experiments were performed in four groups of uninephrectomized Sprague-Dawley rats 3, 7, 14 and 21 days after treatment with: (I) DOCA a...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Chen YF,Lindheimer MD,Oparil S

    更新日期:1986-01-01 00:00:00

  • Ultrastructure of HRP-labelled neurons: a comparison of two sensitive techniques.

    abstract::Rat sciatic nerves were transected and placed in a solution of HRP. Following perfusion, L4-6 spinal segments and sensory ganglia were cut into 60 micron sections. Alternate sections were processed with the glucose oxidase (GOD) or the benzidine dihydrochloride (BDHC) procedure. Sections were then either mounted on gl...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Mawe GM,Bresnahan JC,Beattie MS

    更新日期:1983-04-01 00:00:00

  • Response inhibition failure to visual stimuli paired with a "single-type" stressor in PTSD patients: an fMRI pilot study.

    abstract::Patients with post-traumatic stress disorder (PTSD) tend to misinterpret innocuous stimuli as potential threats, possibly due to a conditioning provoked by traumatic episodes. Previous neuroimaging evidence has shown an abnormal activation of the amygdala and prefrontal cortex in PTSD patients during fear conditioning...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Brunetti M,Sepede G,Ferretti A,Mingoia G,Romani GL,Babiloni C

    更新日期:2015-05-01 00:00:00

  • Silencing of miR-302b-3p alleviates isoflurane-induced neuronal injury by regulating PTEN expression and AKT pathway.

    abstract::Isoflurane (ISO) is an anesthesia and can result in neuron injury. A previous study has indicated that microRNA-302b-3p (miR-302b-3p) exerts a crucial function in modulating cerebral ischemia/reperfusion damage-induced neuronal injury. We sought to examine the role of miR-302b-3p in ISO-induced neuronal injury. In the...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Li L,Lu S,Fan X

    更新日期:2020-12-25 00:00:00

  • NMDA and non-NMDA receptor antagonists inhibit photic induction of Fos protein in the hamster suprachiasmatic nucleus.

    abstract::We previously reported that systemic treatment with a noncompetitive antagonist affecting the NMDA subtype of excitatory amino acid (EAA) receptor, MK-801, inhibits photic induction of Fos-like immunoreactivity (Fos-lir) in the hamster suprachiasmatic nucleus (SCN). Because MK-801 blocks the Ca2+ channel associated wi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Abe H,Rusak B,Robertson HA

    更新日期:1992-05-01 00:00:00

  • Sexual dimorphism in the pituitary-adrenal response to tumor necrosis factor-alpha, but not to interleukin-6, in the rat.

    abstract::It is known that the pituitary-adrenal responses to lipopolysaccharide and interleukin (IL)-1 are sexually dimorphic in rodents, with females having an enhanced secretion of adrenocorticotropin (ACTH) and corticosterone. This study investigated whether the ACTH and corticosterone responses to tumor necrosis factor (TN...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Watanobe H

    更新日期:2002-01-15 00:00:00

  • Behavioral and dorsal raphe neuronal activity following acute and chronic methylphenidate in freely behaving rats.

    abstract::Concomitant behavioral and dorsal raphe (DR) neuronal activity were recorded following acute and chronic dose response of methylphenidate (MPD) in freely moving rats previously implanted with permanent semi-microelectrodes using telemetric (wireless) technology. On experimental day (ED) 1, the neuronal and locomotor a...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Tang B,Dafny N

    更新日期:2013-09-01 00:00:00

  • Molecular and cellular mechanisms of opiate action: studies in the rat locus coeruleus.

    abstract::We have studied the molecular and cellular mechanisms underlying the acute and chronic effects of opiate on neurons of the rat locus coeruleus (LC). Acutely, opiates inhibit LC neurons by activating K+ channels and inhibiting a novel sodium-dependent inward current. Both of these actions are mediated via pertussis tox...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Nestler EJ,Alreja M,Aghajanian GK

    更新日期:1994-01-01 00:00:00

  • Effect of progesterone on monoamine turnover in the brain of the estrogen-primed rat.

    abstract::The effect of progesterone (P) on monoamine levels and turnover was evaluated in 8 brain nuclei in estrogen-primed rats. Animals were subcutaneously (SC) injected with P or vehicle 21 hours after SC treatment with 5 micrograms of estradiol benzoate (EB). EB-primed animals treated with P showed high levels of lordosis ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Renner KJ,Krey LC,Luine VN

    更新日期:1987-08-01 00:00:00

  • Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats.

    abstract::Pax6 is an important transcription factor expressed in several discrete domains of the developing central nervous system. It has been reported that Pax6 is involved in the specification of subtypes of hindbrain motor neurons. Pax6 homozygous mutant (rSey2/rSey2) rats die soon after birth, probably due to impaired resp...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Ikeda K,Onimaru H,Inada H,Tien Lin S,Arata S,Osumi N

    更新日期:2019-10-01 00:00:00

  • Comparison of fractal and power spectral EEG features: effects of topography and sleep stages.

    abstract::Fractal nature of the human sleep EEG was revealed recently. In the literature there are some attempts to relate fractal features to spectral properties. However, a comprehensive assessment of the relationship between fractal and power spectral measures is still missing. Therefore, in the present study we investigated...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Weiss B,Clemens Z,Bódizs R,Halász P

    更新日期:2011-04-05 00:00:00

  • Cells with neuronal characteristics differentiate and persist for one year in rat optic nerve explants cultures.

    abstract::Evidence concerning the presence or absence of common neuronglia lineages in the postnatal mammalian central nervous system is still a matter of speculation. We address this problem using optic nerve explants, which show an extremely long survival in culture. Morphological, immunocytochemical and immunochemical method...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Omlin FX,Riederer BM

    更新日期:1992-01-01 00:00:00

  • Body weight supported gait training: from laboratory to clinical setting.

    abstract::After spinal cord injury (SCI) of the cat or rat neuronal centres below the level of lesion exhibit plasticity that can be exploited by specific training paradigms. In individuals with complete or incomplete SCI, human spinal locomotor centers can be activated by appropriate afferent input. This includes to facilitate...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审


    authors: Dietz V

    更新日期:2009-01-15 00:00:00

  • Involvement of the serotonergic system in the hypoactive and antinociceptive effects of nicotine in mice.

    abstract::Pretreatment with the 5-HT2 antagonist ketanserin and the 5-HT1A/2 antagonist spiperone did not reduce nicotine-induced hypomotility in mice, nor did MDL 7222, a selective 5-HT3 antagonist. In addition, 8-OH-DPAT and buspirone, 5-HT1A agonists, had no significant effects on nicotine-induced hypomotility. However, 8-OH...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Damaj MI,Glennon RA,Martin BR

    更新日期:1994-01-01 00:00:00

  • Lack of evidence for serotonergic effect on the cellular development of the olfactory bulb in the postnatal rat.

    abstract::Serotonin has been postulated to influence several developmental parameters. The potential role of serotonin in the development of the rat olfactory bulb, a simple cortical structure, was determined following selective depletion of serotonin to the olfactory bulb of neonate rats. In the neonate, 5,7-dHT was injected i...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: McLean JH,Darby-King A

    更新日期:1994-01-01 00:00:00

  • A single-nucleotide polymorphism induced alternative splicing in Tacr3 involves in hypoxic-ischemic brain damage.

    abstract::Single-nucleotide polymorphism (SNP) and Alternative splicing (AS) were found to be implicated in certain diseases, nevertheless, the contributions of mRNA SNPs and AS to pathogenesis in developing rat brains with hypoxic-ischemic encephalopathy (HIE) remained largely vague. Additionally, the disease associated with T...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Xue LL,Wang F,Xiong LL,Du RL,Zhou HL,Zou Y,Wu MX,Yang MA,Dai J,He MX,Wang TH

    更新日期:2020-01-01 00:00:00

  • Prenatal heroin exposure alters cholinergic receptor stimulated activation of the PKCbetaII and PKCgamma isoforms.

    abstract::Prenatal exposure of mice to heroin (SC injection of 10mg/kg to the dams on gestational days 9-18) resulted at adulthood in behavioral deficits related to septohippocampal cholinergic innervation accompanied with both presynaptic and postsynaptic cholinergic hyperactivity; including an increase membrane PKC activity, ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Yaniv SP,Naor Z,Yanai J

    更新日期:2004-05-30 00:00:00

  • Endogenous opioids and hypogonadism in human obesity.

    abstract::Massively obese males often show symptoms of hypogonadism, but the mechanism for this is unclear. Increased endogenous opioid inhibition of the hypothalamic GnRH pulse generator resulting in insufficient stimulation of the pituitary gonadotroph has been proposed as a possible mechanism. If this hypothesis is correct, ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Blank DM,Clark RV,Heymsfield SB,Rudman DR,Blank MS

    更新日期:1994-01-01 00:00:00

  • Cerebral cortex and amino acid neurotransmitters: higher levels of aspartic acid but not GABA in the frontal cortex of the rat.

    abstract::Endogenous levels of Aspartic acid, GABA and Glutamic acid plus Glutamine were measured in the frontal, occipital, temporal and parietal cortex. Aspartic acid levels were found higher in the frontal cortex than in the rest of the cortical areas studied. GABA, however, had a homogenous distribution among all cortical a...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Peinado JM,Gomez-Capilla JA,Mora F

    更新日期:1984-06-01 00:00:00

  • Increased expression of HERPUD1 involves in neuronal apoptosis after intracerebral hemorrhage.

    abstract::Homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein (HERPUD1) is involved in endoplasmic reticulum stress response. Immense amounts of research showed HERPUD1 plays multiple roles in various models. In this work, we explored the role of HERPUD1 during the pathophysiolog...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Ding W,Chen R,Wu C,Chen W,Zhang H,Fan X,Wang H,Ji Y,Xie L,Ning X,Shen L

    更新日期:2017-01-01 00:00:00

  • Hippocampal deafferentation and deefferentation and gastric pathology in rats.

    abstract::Previous studies have shown that large hippocampal lesions increase the gastric pathology found in restrained and unrestrained animals. The present experiments investigated the effects of lesions in the two major afferent and efferent pathways of the hippocampus, i.e., the dorsal pathway through the fimbria-fornix and...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Henke PG,Savoie RJ,Callahan BM

    更新日期:1981-10-01 00:00:00

  • Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation.

    abstract::Expression of the Huntington's disease (HD) mutation in mice (R6/2 line) causes a progressive neurological phenotype that includes deterioration of motor function resembling that seen in HD. The current study sought to determine whether or not chronic treatment of R6/2 mice with lithium chloride would have an effect o...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Wood NI,Morton AJ

    更新日期:2003-08-30 00:00:00

  • Sensitivity of lateral hypothalamic neurons to glycemic level: possible involvement of an indirect adrenergic mechanism.

    abstract::Most of the lateral hypothalamic neurons responding to moderate changes in blood glucose fail to be affected by direct glucose applications. Therefore their sensitivity to glycemic level must be mediated by an indirect mechanism. In order to test whether adrenergic afferents might be involved, the activity of lateral ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Orsini JC,Wiser AK,Himmi T,Boyer A,Perrin J

    更新日期:1991-04-01 00:00:00

  • Osthole alleviated diabetic neuropathic pain mediated by the P2X4 receptor in dorsal root ganglia.

    abstract::Diabetes mellitus (DM) is considered the primary cause of neuropathic pain. Osthole (7-methoxy-8[3-methylpent 2-enyl]coumarin) is a component extracted from Cnidium monnieri (L.) cusson plant seeds and has anti-inflammatory and anti-oxidative properties. The aim of the present study was to investigate the effects of o...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Yuan H,Ouyang S,Yang R,Li S,Gong Y,Zou L,Jia T,Zhao S,Wu B,Yi Z,Liu H,Shi L,Li L,Gao Y,Li G,Xu H,Liu S,Zhang C,Liang S

    更新日期:2018-09-01 00:00:00

  • Is the dentate gyrus an independent generator of in vitro recorded theta rhythm?

    abstract::In this study we investigated the ability of the dentate gyrus to independently generate cholinergically induced theta rhythm in vitro. Two different experiments were performed. In Experiment I, new laminar profiles of theta phase, amplitude, and current sources and sinks were constructed. In this experiment a gradual...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Kowalczyk T,Gołebiewski H,Konopacki J

    更新日期:2009-09-28 00:00:00

  • Hypophagic and dipsogenic effects of central 5-HT injections in pigeons.

    abstract::The present work describes a series of experiments designed to examine the possible role of central 5-HT circuits in the control of feeding and drinking in pigeons. Acute effects (within 1 h) of intracerebroventricular (ICV) injections of 5-HT (0, 9.7, 19.4, 38.7, 77.5, 155, and 310 nmol) in 24-h food-deprived (24FD) ...

    journal_title:Brain research bulletin

    pub_type: 杂志文章


    authors: Steffens SM,Casas DC,Milanez BC,Freitas CG,Paschoalini MA,Marino-Neto J

    更新日期:1997-01-01 00:00:00