Abstract：
:In rats, on the 25th day after the start of a thiamine-deficient (TD) diet, impairment of avoidance learning was significantly induced in proportion to the decrease somatostatin (SST) fluorescence intensity in the cortex, amygdala, thalamus, hypothalamus, and hippocampus, including the CA1, CA2, and dentate gyrus (DG). Only a single injection of thiamine HCl (0.5 mg/rat, subcutaneous) on the 14th day after the start of a TD diet improved the amnesia to the level of the pair-fed control and prevented the decrease in the SST level. Whereas these reversal effects of thiamine treatment were not found when the treatment was given on the 21st day after the start of a TD diet. These results indicate that, after a certain degree of thiamine deficiency, TD-induced behavioral effects might be reversible, but some neuronal fibers might be irreversibly damaged, probably due to the reduction of thiamine-dependent enzymes in brain mitochondria. The results also suggest the possibility that SST in the brain may be closely related to the avoidance learning impairment induced by TD.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Nakagawasai O,Tadano T,Niijima F,Tan-No K,Kisara Kdoi
10.1016/s0361-9230(99)00201-4keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
47-55issue
1eissn
0361-9230issn
1873-2747pii
S0361-9230(99)00201-4journal_volume
51pub_type
杂志文章abstract：:Ethanol has a pharmacological profile similar to other centrally acting drugs, which facilitate GABAergic transmission. GABA is known to produce its effects by increasing the conductance to Cl- ions. In this study, we have examined the effect of ethanol on GABA-induced 36Cl-influx in primary spinal cord cultured neuro...
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1994-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-04-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1998-07-15 00:00:00
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pub_type： 杂志文章
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更新日期：2003-11-15 00:00:00
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pub_type： 杂志文章
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更新日期：1990-02-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1984-06-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1987-10-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2000-01-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2003-06-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90135-x
更新日期：1994-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90136-8
更新日期：1991-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(89)90212-8
更新日期：1989-10-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2009.05.005
更新日期：2009-08-14 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(99)00039-8
更新日期：1999-04-01 00:00:00
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更新日期：2007-01-09 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1982-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2002-02-01 00:00:00
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journal_title：Brain research bulletin
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更新日期：2017-09-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(82)90097-1
更新日期：1982-06-01 00:00:00
abstract：:The biochemical balance between right- and left-ascending DA systems is an essential factor to regulate behavioral lateralization. However, there is no electrophysiological evidence for the regulation of interhemispheric DA systems. In the present paper we report electrophysiological evidence supporting the hypothesis...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90070-z
更新日期：1991-08-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2012.06.008
更新日期：2012-10-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2003-09-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.06.022
更新日期：2007-09-28 00:00:00
abstract：:The gonadotropin-releasing hormone-associated peptide (GAP) and luteinizing hormone-releasing hormone (LHRH) portions of the LHRH precursor were localized by immunocytochemistry in prepubertal female rats, in adult female rats at different stages of the estrous cycle, and in ovariectomized rats. Our results indicate t...
journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1988-06-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0361-9230(93)90142-x
更新日期：1993-01-01 00:00:00
