Abstract:
:The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Kakinoki H,Ishizawa K,Fukunaga M,Fujii Y,Kamei Cdoi
10.1016/s0361-9230(98)00048-3subject
Has Abstractpub_date
1998-07-15 00:00:00pages
461-5issue
5eissn
0361-9230issn
1873-2747pii
S0361923098000483journal_volume
46pub_type
杂志文章abstract::"Responder" Sprague-Dawley (SD) rats that were sensitive to electroacupuncture (EA) in an acute thermal pain test (i.e. tail flick latency [TFL] test) maintained sensitivity to EA in the warm allodynia test after peripheral nerve injury. Similarly, the "non-responder" SD rats that were insensitive to EA in the TFL tes...
journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(78)90014-x
更新日期:1978-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.10.036
更新日期:2008-03-18 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2012.07.011
更新日期:2012-11-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90133-0
更新日期:1989-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.07.015
更新日期:2020-10-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2017.11.009
更新日期:2018-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1998-09-15 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00661-x
更新日期:2001-12-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2014.03.003
更新日期:2014-05-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.09.020
更新日期:2009-03-30 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2020.04.010
更新日期:2020-08-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90124-t
更新日期:1993-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(90)90277-7
更新日期:1990-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2017.07.021
更新日期:2017-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2010.02.013
更新日期:2010-04-29 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.08.010
更新日期:2018-09-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90124-2
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.02.033
更新日期:2005-07-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90040-6
更新日期:1984-10-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2019.11.011
更新日期:2020-02-01 00:00:00
abstract::Maternal immune activation during pregnancy is a risk factor for neurodevelopmental disorders, such as schizophrenia; however, a full mechanistic understanding has yet to be established. The activity of a transient cell population, the subplate neurons, is critical for the development of cortical inhibition and functi...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2017.10.006
更新日期:2017-10-01 00:00:00
abstract::Promoting remyelination and/or minimizing demyelination are key therapeutic strategies under investigation for diseases and injuries like multiple sclerosis (MS), spinal cord injury, stroke, and virus-induced encephalopathy. Myelination is essential for efficacious neuronal signaling. This myelination process is origi...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2019.07.013
更新日期:2019-10-01 00:00:00
abstract::To elucidate whether pineal melatonin secretion is affected by changes in day length, we determined the concentration of melatonin in human pineal glands obtained at autopsy from 66 male subjects, aged 16-84 years over a period of 12 consecutive months. Based on the time of death, a day-night difference in pineal mela...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(98)00105-1
更新日期:1998-10-01 00:00:00
abstract::The nucleus retroambiguus (NRA) is a group of neurons, located laterally in the caudal medulla oblongata. The NRA is thought to modulate abdominal pressure in the framework of respiration, vomiting, vocalization, probably parturition, and, in all likelihood mating behavior. The NRA exerts this control through its proj...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2005.08.011
更新日期:2006-01-15 00:00:00
abstract::To examine synaptic input and association of terminals containing dopamine and other transmitters to rat striatal nitric oxide synthase-expressing neurons, an electron microscopic study using tyrosine hydroxylase (TH) immunohistochemistry combined with histochemistry for NADPH-diaphorase (NADPHd) was performed. NADPHd...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(96)00035-4
更新日期:1996-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(01)00523-8
更新日期:2001-07-15 00:00:00
abstract::Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression ar...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2008.12.002
更新日期:2009-03-30 00:00:00
abstract::Administering increasing dosages of 5alpha-dihydrotestosterone propionate (DHTP) (0, 40, or 80 microgram/100 g in oil daily) to ovariectomized female rats treated concurrently with estradiol benzoate (EB) (1 microgram/100 g in oil daily) caused significant, equivalent reduction in lordotic responsiveness in rats maint...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(81)90090-3
更新日期:1981-07-01 00:00:00