5-Aminoimidazole-4-carboxamide riboside (AICAr) administration reduces cerebral ischemic damage in the Mongolian gerbil.

abstract：:Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression ar...

journal_title：Brain research bulletin

authors： Yuluğ B,Ozan E,Gönül AS,Kilic E

更新日期：2009-03-30 00:00:00

abstract：:Although interleukin-1β (IL-1β) is a prototypical pro-inflammatory cytokine, the specific mechanisms underlying the role of its cognate receptor, the interleukin-1 receptor (IL-1R) in peripheral sensitization remain to be investigated. Since emerging evidence in the literature indicates that IL-1β can modulate membran...

journal_title：Brain research bulletin

authors： Kwon SG,Roh DH,Yoon SY,Choi SR,Choi HS,Moon JY,Kang SY,Beitz AJ,Lee JH

更新日期：2017-04-01 00:00:00

abstract：:We have studied the molecular and cellular mechanisms underlying the acute and chronic effects of opiate on neurons of the rat locus coeruleus (LC). Acutely, opiates inhibit LC neurons by activating K+ channels and inhibiting a novel sodium-dependent inward current. Both of these actions are mediated via pertussis tox...

journal_title：Brain research bulletin

authors： Nestler EJ,Alreja M,Aghajanian GK

更新日期：1994-01-01 00:00:00

abstract：:Calcium/calmodulin-dependent protein-kinase II (CaMKII) is a ubiquitous intracellular enzyme, which is implicated in learning and memory mechanisms in the central nervous system, however its contribution to peripheral cholinergic neurotransmission is not well characterized. This study evaluated the impact of CaMKII on...

journal_title：Brain research bulletin

authors： Mukhamedyarov MA,Kochunova JO,Yusupova ER,Haidarov BA,Zefirov AL,Palotás A

更新日期：2010-04-05 00:00:00

abstract：:The nucleus locus coeruleus (LC) has been implicated in the modulation of the spinal sensorimotor function. The aim of the present study was to examine the effect of electrical stimulation of the LC on sensorimotor function in the trigeminal system. The following two cases of sensorimotor behaviors mediated by the tri...

journal_title：Brain research bulletin

authors： Matsutani K,Tsuruoka M,Shinya A,Furuya R,Kawawa T

更新日期：2000-12-01 00:00:00

abstract：:Fipronil, a GABA(A) receptor antagonist, is replacing many insecticide uses formerly fulfilled by organophosphates like chlorpyrifos. Few studies have addressed the potential for fipronil to produce developmental neurotoxicity. We compared the neurotoxicity of fipronil and chlorpyrifos in undifferentiated and differen...

journal_title：Brain research bulletin

authors： Lassiter TL,MacKillop EA,Ryde IT,Seidler FJ,Slotkin TA

更新日期：2009-03-30 00:00:00

abstract：:Accumulating evidence points to the amyloid-β (Aβ) peptide as the culprit in the pathogenesis of Alzheimer's disease (AD). β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1) is a protease that is responsible for initiating Aβ production. Although precise mechanisms that trigger Aβ accumulation remain unc...

journal_title：Brain research bulletin

authors： Ohno M

更新日期：2016-09-01 00:00:00

abstract：:Aluminium is highly neurotoxic and inhibits prenatal and postnatal development of the brain in humans and experimental animals. However, the incorporation of aluminium into the brain of fetuses and sucklings during gestation and lactation has not been well clarified because aluminium lacks a suitable isotope for a tra...

journal_title：Brain research bulletin

authors： Yumoto S,Nagai H,Matsuzaki H,Matsumura H,Tada W,Nagatsuma E,Kobayashi K

更新日期：2001-05-15 00:00:00

abstract：:Isoflurane (ISO) is an anesthesia and can result in neuron injury. A previous study has indicated that microRNA-302b-3p (miR-302b-3p) exerts a crucial function in modulating cerebral ischemia/reperfusion damage-induced neuronal injury. We sought to examine the role of miR-302b-3p in ISO-induced neuronal injury. In the...

journal_title：Brain research bulletin

authors： Li L,Lu S,Fan X

更新日期：2020-12-25 00:00:00

abstract：:Aβ plaques of Alzheimer's disease (AD) are believed to precede cognitive deficits or clinical manifestation by decades. However, validated biomarkers for early diagnosis of the AD disease are still not available. In this present study, we combined MRI-based neuroimages and histological assessment of the glial response...

journal_title：Brain research bulletin

authors： Liu L,Liu Y,Li N,Huang R,Zheng X,Huang L,Hou S,Yuan Q

更新日期：2020-03-01 00:00:00

abstract：:Ca(2+)/calmodulin-dependent kinase II (CaMKII) is an abundant synaptic signalling molecule that is essential for memory formation and the induction of synaptic potentiation. Additionally, CaMKII plays a prominent role in synaptic tagging and metaplasticity. These abilities are mediated by kinase activity as well as bi...

journal_title：Brain research bulletin

authors： Lucchesi W,Mizuno K,Giese KP

更新日期：2011-04-25 00:00:00

abstract：:Neonatal post-hemorrhagic hydrocephalus is associated with cognitive decline and a serious deterioration in the patient's quality of life. The underlying impairments to neurons are not well understood. Here, we used the method described by Cherian et al. to construct a model of hydrocephalus after intra-ventricular he...

journal_title：Brain research bulletin

authors： Chen X,Huang X,Li B,Zhao Z,Jiang L,Huang C,Lu Y

更新日期：2010-08-30 00:00:00

abstract：:Fatty acid amide hydrolase (FAAH) is an enzyme that metabolizes endocannabinoids and fatty acid amides possibly linked to activation of the opioid system. To examine how this enzyme affects spinal signalling, electrophysiological recordings in the dorsal horn and qPCR on dorsal horn tissue following systemic administr...

journal_title：Brain research bulletin

authors： Eriksen GS,Jacobsen LM,Mahmood A,Pedersen LM,Gjerstad J

更新日期：2012-02-10 00:00:00

abstract：:Parkinson's-diseased (PD) brains have been reported to contain increased quantities of iron within the zona compacta of the substantia nigra (SN). To test whether excess iron in the SN could cause a PD-like loss of dopaminergic neurons, various concentrations of iron were infused unilaterally within the SN of adult ma...

journal_title：Brain research bulletin

authors： Sengstock GJ,Olanow CW,Dunn AJ,Arendash GW

更新日期：1992-04-01 00:00:00

abstract：:The rostral pons of the cat and rhesus monkey were examined for the presence of labeled cells following injections of horseradish peroxidase (HRP) into the lumbar spinal cord. Labeled cells were found in the ipsilateral dorsolateral pontine tegmentum and in the contralateral ventrolateral pontine reticular formation. ...

journal_title：Brain research bulletin

authors： Hancock MB,Fougerousse CL

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:Transcranial near-infrared stimulation (tNIRS) can penetrate the scalp and skull and can reach the superficial layers of the cerebral cortex. In this study, we evaluated whether an 820-nm tNIRS can modulate the excitability of the primary motor cortex (M1) as measured by transcranial magnetic stimulation (TMS...

journal_title：Brain research bulletin

authors： Song P,Han T,Lin H,Li S,Huang Q,Dai X,Wang R,Wang Y

更新日期：2020-02-01 00:00:00

abstract：:The influence of gender and stage of the estrous cycle on the levels of acetylcholine, serotonin, and noradrenaline in the hippocampus and on the susceptibility of the cholinergic septo-hippocampal pathway to the neurotoxic effect of ethylcholine aziridinium (AF64A) was investigated in the rat. Levels of acetylcholine...

journal_title：Brain research bulletin

authors： Hörtnagl H,Hansen L,Kindel G,Schneider B,el Tamer A,Hanin I

更新日期：1993-01-01 00:00:00

abstract：:Glaucoma is no longer viewed simply as elevated intraocular pressure (IOP) that damages the optic nerve. In addition to high IOP, evidence is rapidly accumulating that suggests damage to the optic nerve may be initiated or sustained by any number of factors including ischemia, excitotoxicity, neurotrophin insufficienc...

journal_title：Brain research bulletin

authors： Tezel G,Yang J,Wax MB

更新日期：2004-02-15 00:00:00

abstract：:Traumatic brain injury (TBI) is a major public-health problem for which mild TBI (MTBI) makes up majority of the cases. MTBI is a poorly-understood health problem and can persist for years manifesting into neurological and non-neurological problems that can affect functional outcome. Presently, diagnosis of MTBI is ba...

journal_title：Brain research bulletin

authors： Kan EM,Ling EA,Lu J

更新日期：2012-03-10 00:00:00

abstract：:Anxiety disorders and nicotine use are significant contributors to global morbidity and mortality as independent and comorbid diseases. Early-life stress, potentially via stress-induced hypothalamic-pituitary-adrenal axis (HPA) dysregulation, can exacerbate both. However, little is known about the factors that predisp...

journal_title：Brain research bulletin

authors： Caruso MJ,Reiss DE,Caulfield JI,Thomas JL,Baker AN,Cavigelli SA,Kamens HM

更新日期：2018-04-01 00:00:00

abstract：:In this study, we compared the depression-like symptoms induced by olfactory bulbectomy (OBX) in the two inbred Wistar and Long Evans rat strains. We also analyzed the self-regulated oral intake of nicotine in these strains and the effect of nicotine on the depression-like symptoms of olfactory bulbectomy. Furthermore...

journal_title：Brain research bulletin

authors： Vieyra-Reyes P,Mineur YS,Picciotto MR,Túnez I,Vidaltamayo R,Drucker-Colín R

更新日期：2008-09-05 00:00:00

abstract：:The olfactory bulb (OB) of the rat receives an extrinsic innervation from the most anterior part of the basal forebrain cholinergic complex. The effect of microiontophoretically applied acetylcholine (ACh) on OB unit activity was studied in 16 adult male rats. A total of 80 units was recorded and in 50% of the cases t...

journal_title：Brain research bulletin

authors： Ravel N,Akaoka H,Gervais R,Chouvet G

更新日期：1990-02-01 00:00:00

abstract：:A biotinylated oligonucleotide probe was used to demonstrate the presence in the heart of the portion of the proopiomelanocortin messenger RNA which contains the sequence for beta-endorphin. The probe indicated the presence of beta-endorphin messenger RNA in cardiac tissue and specifically in the cardiac muscle cell. ...

journal_title：Brain research bulletin

authors： Forman LJ,Bagasra O

更新日期：1992-03-01 00:00:00

abstract：:The effect of the intracerebroventricular (ICV) administration of pertussis toxin on penile erection and yawning induced by apomorphine and oxytocin was studied in male rats. Pertussis toxin (2 micrograms ICV) prevented the above behavioral responses to apomorphine (80 micrograms/kg SC) and oxytocin (30 ng ICV) on day...

journal_title：Brain research bulletin

authors： Stancampiano R,Melis MR,Argiolas A

更新日期：1992-02-01 00:00:00

abstract：:Electrical stimulation has been shown to have neuroprotective effects on ganglion cells and photoreceptors in axotomized and dystrophic retinas from Royal College of Surgeons (RCS) rats. This study determined whether electrical stimulation also has a neuroprotective effect on cells in the inner nuclear layer (INL) of ...

journal_title：Brain research bulletin

authors： Schmid H,Herrmann T,Kohler K,Stett A

更新日期：2009-04-06 00:00:00

abstract：:Impairment of endosomal/lysosomal functions are reported as some of the earliest changes in several age-related neurological disorders such as Alzheimer's disease. Dysregulation of the lysosomal system is also accompanied by the accumulation of age-associated pigments and several recent reports have indicated that thi...

journal_title：Brain research bulletin

authors： Ditaranto-Desimone K,Saito M,Tekirian TL,Saito M,Berg M,Dubowchik G,Soreghan B,Thomas S,Marks N,Yang AJ

更新日期：2003-02-15 00:00:00

abstract：:The effects of intracerebroventricular (ICV) colchicine (70 micrograms per rat) on systolic pressures and levels of hexokinase activity in the hypothalamic paraventricular (PVH) and supraoptic (SON) nuclei were investigated in adult normotensive and spontaneously hypertensive rats (SHR). One day after colchicine injec...

journal_title：Brain research bulletin

authors： Krukoff TL,Vincent DH

更新日期：1989-07-01 00:00:00

abstract：:The discovery of spontaneous neuronal replacement in the adult vertebrate brain has changed the way in which we think about the biology of memory. This is because neuronal replacement is likely to have an impact on what a brain remembers and what it learns. Neuronal replacement has also changed the way in which we go ...

journal_title：Brain research bulletin

authors： Nottebohm F

更新日期：2002-04-01 00:00:00

abstract：:Nutritional factors and nutritional deficiencies have been repeatedly associated with cognitive impairment. Most of the evidence is based on cross-sectional studies, which cannot prove whether a nutritional deficit is the cause or the consequence of an impaired cognitive status. In fact, cognitive impairment, in turn,...

journal_title：Brain research bulletin

authors： Del Parigi A,Panza F,Capurso C,Solfrizzi V

更新日期：2006-03-15 00:00:00

abstract：:There are cholinergic inputs responsible for pressor responses in the rostral ventrolateral medulla (RVLM) and stimulation of midbrain central gray (CG) increases arterial pressure via activation of neurons in the RVLM. In this study, we examined whether the CG was involved in mediation of the cholinergic inputs to th...

journal_title：Brain research bulletin

authors： Kubo T,Hagiwara Y,Sekiya D,Fukumori R

更新日期：1999-09-01 00:00:00