Abstract:
:The effect of the intracerebroventricular (ICV) administration of pertussis toxin on penile erection and yawning induced by apomorphine and oxytocin was studied in male rats. Pertussis toxin (2 micrograms ICV) prevented the above behavioral responses to apomorphine (80 micrograms/kg SC) and oxytocin (30 ng ICV) on day 3 and 4, but not on day 0 and 1 after treatment. Oxytocin and apomorphine responses were restored on day 6. Similar results were obtained by microinjecting pertussis toxin (0.5 microgram) in the paraventricular nucleus of the hypothalamus, the most sensitive brain area for the induction of penile erection and yawning by oxytocin and apomorphine. The results suggest that G proteins are involved in the expression of above responses to apomorphine and oxytocin.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Stancampiano R,Melis MR,Argiolas Adoi
10.1016/0361-9230(92)90194-3keywords:
subject
Has Abstractpub_date
1992-02-01 00:00:00pages
315-8issue
2eissn
0361-9230issn
1873-2747pii
0361-9230(92)90194-3journal_volume
28pub_type
杂志文章abstract::This study tested for the presence of androgen receptor-immunoreactivity in somatostatin, galanin, vasopressin, corticotropin-releasing hormone, and oxytocin neurons in the rat forebrain. The brains of adult male Sprague-Dawley rats were fixed with 4% paraformaldehyde. Androgen receptor was visualized in coronal secti...
journal_title:Brain research bulletin
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journal_title:Brain research bulletin
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pub_type: 临床试验,杂志文章
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