Apomorphine- and oxytocin-induced penile erection and yawning in male rats: effect of pertussis toxin.

Abstract:

:The effect of the intracerebroventricular (ICV) administration of pertussis toxin on penile erection and yawning induced by apomorphine and oxytocin was studied in male rats. Pertussis toxin (2 micrograms ICV) prevented the above behavioral responses to apomorphine (80 micrograms/kg SC) and oxytocin (30 ng ICV) on day 3 and 4, but not on day 0 and 1 after treatment. Oxytocin and apomorphine responses were restored on day 6. Similar results were obtained by microinjecting pertussis toxin (0.5 microgram) in the paraventricular nucleus of the hypothalamus, the most sensitive brain area for the induction of penile erection and yawning by oxytocin and apomorphine. The results suggest that G proteins are involved in the expression of above responses to apomorphine and oxytocin.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Stancampiano R,Melis MR,Argiolas A

doi

10.1016/0361-9230(92)90194-3

keywords:

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

315-8

issue

2

eissn

0361-9230

issn

1873-2747

pii

0361-9230(92)90194-3

journal_volume

28

pub_type

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