Medial versus lateral parabrachial nucleus lesions in the rat: effects on mercaptoacetate-induced feeding and conditioned taste aversion.

Abstract:

:The two experiments of the present study examined the influence of bilateral electrophysiologically-guided ibotenic acid lesions of the medial (gustatory) and lateral (viscerosensory) subdivisions of the parabrachial nucleus (PBN) on lipoprivic feeding and on the acquisition of a conditioned taste aversion. In Experiment 1, mercaptoacetate (0, 400, 600, or 800 micromol/kg) failed to enhance food intake in normal rats maintained and tested on standard laboratory chow. In the same procedure, rats with lesions of the medial or lateral PBN consumed less food during baseline but nonetheless were sensitive to the orexigenic action of mercaptoacetate. In Experiment 2, both types of PBN lesions prevented acquisition of a conditioned taste aversion induced by the oral self administration of lithium chloride. The results suggest that PBN neurons essential for conditioned taste aversion are not involved in the mercaptoacetate-induced feeding of rats maintained and tested on standard laboratory chow.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Trifunovic R,Reilly S

doi

10.1016/s0361-9230(02)00766-9

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

107-13

issue

1

eissn

0361-9230

issn

1873-2747

pii

S0361923002007669

journal_volume

58

pub_type

杂志文章
  • Amphetamine: effects on meal patterns and macronutrient selection.

    abstract::Catecholaminergic systems, specifically in the region of the lateral perifornical hypothalamus (PFH), have been linked to the inhibition of feeding behavior. The present studies examined the effects of d-amphetamine (AMPH), which is believed to act through the release of endogenous catecholamines (CAs), on spontaneous...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(86)90200-5

    authors: Leibowitz SF,Shor-Posner G,Maclow C,Grinker JA

    更新日期:1986-11-01 00:00:00

  • Epigenetic regulation of death of crayfish glial cells but not neurons induced by photodynamic impact.

    abstract::Epigenetic processes are involved in regulation of cell functions and survival, but their role in responses of neurons and glial cells to oxidative injury is insufficiently explored. Here, we studied the role of DNA methylation and histone deacetylation in reactions of neurons and surrounding glial cells to photodynam...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2014.01.005

    authors: Sharifulina SA,Komandirov MA,Uzdensky AB

    更新日期:2014-03-01 00:00:00

  • Hypothalamic c-fos-like immunoreactivity in high-fat diet-induced obese and resistant mice.

    abstract::Some C57Bl/6 mice become obese, whereas others remain lean when raised on a high-fat diet. The mechanisms underlying this interindividual susceptibility to diet-induced obesity remain unknown. Because hypothalamus plays a major role in the regulation of body weight, this study was conducted to identify the differences...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(00)00228-8

    authors: Xin X,Storlien LH,Huang XF

    更新日期:2000-07-01 00:00:00

  • Dose-dependent brainstem neuropathology following repeated arteether administration in rats.

    abstract::Histopathological effects of the artemisinin antimalarial, beta-arteether, were evaluated in rats. Arteether (3.125-12.5 mg/kg/day, IM, in sesame oil) was administered for 7 consecutive days. Seven days following the last injection, histological evaluation of the brainstem was performed. Rats treated with 12.5 mg/kg s...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/s0361-9230(97)00339-0

    authors: Genovese RF,Newman DB,Li Q,Peggins JO,Brewer TG

    更新日期:1998-01-01 00:00:00

  • Hippocampal theta activity in the acute precollicular rat.

    abstract::In eleven acute precollicular rats, cortical and hippocampal EEG activity was recorded. Hippocampal theta activity of low frequency (mean 4.5 c/sec) was found in nine rats and in four occupied above 50% of the recording time. In contrast, in the cortex the synchronized EEG activity dominated. The electrical stimulatio...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(89)90006-3

    authors: Gottesmann C,Gandolfo G,Zernicki B

    更新日期:1989-06-01 00:00:00

  • The Pro-LHRH system of the rat brain. Effects of changes in the endocrine background.

    abstract::The gonadotropin-releasing hormone-associated peptide (GAP) and luteinizing hormone-releasing hormone (LHRH) portions of the LHRH precursor were localized by immunocytochemistry in prepubertal female rats, in adult female rats at different stages of the estrous cycle, and in ovariectomized rats. Our results indicate t...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(88)90082-2

    authors: Merchenthaler I,Culler MD,Negro-Vilar A,Petrusz P,Flerko B

    更新日期:1988-06-01 00:00:00

  • Transient cerebral vasodilatory effect of neuropeptide Y mediated by nitric oxide.

    abstract::The effects of intracarotidly injected neuropeptide Y (NPY; 0.1 micrograms/kg) on the local cerebral blood volume (CBV) and blood flow (CBF) in the parieto-temporal cortex were examined by the photoelectric method in 17 anesthetized cats. CBV reflects the cumulative crosssectional area of the cerebral microvascular be...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90107-m

    authors: Kobari M,Fukuuchi Y,Tomita M,Tanahashi N,Yamawaki T,Takeda H,Matsuoka S

    更新日期:1993-01-01 00:00:00

  • Differential interactive effects of gliotoxin and MPTP in the substantia nigra and the locus coeruleus in BALB/c mice.

    abstract::We have previously demonstrated that chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) infusion to the substantia nigra (SN) and the locus coeruleus (LC) both produce a long-lasting neurotoxicity on dopamine (DA) and norepinephrine (NE) neurons in these two areas, respectively. In the present study, we furth...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90215-w

    authors: Chang FW,Wang SD,Lu KT,Lee EH

    更新日期:1993-01-01 00:00:00

  • A role for the central histaminergic system in the leptin-mediated increase in cardiovascular dynamics.

    abstract::The central nervous system (CNS) histaminergic neurons have been shown to regulate feeding behavior and are a target of leptin in the brain. The present study aimed to examine the involvement of the histaminergic system in the leptin-mediated regulation of cardiovascular dynamics. We investigated the cardiovascular re...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2004.09.009

    authors: Rao SP,Dunbar JC

    更新日期:2005-01-15 00:00:00

  • Tumor necrosis factor-alpha induces pial arteriolar dilation in newborn pigs.

    abstract::The present study in piglets was designed to examine cerebrovascular effects of tumor necrosis factor-alpha (TNF alpha) and potential mechanisms involved. Anesthetized new-born pigs with closed cranial windows implanted were used. Effects of nitric oxide synthase (NOS) inhibitors, NG-nitro-L-arginine (L-NNA) and amino...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(95)02142-6

    authors: Shibata M,Parfenova H,Zuckerman SL,Leffler CW

    更新日期:1996-01-01 00:00:00

  • Monkey P3 in an "oddball" paradigm: pharmacological support for multiple neural sources.

    abstract::Two experiments examined the effects of the alpha-2 antagonist L657,743 on monkey electroencephalographic (EEG) and event-related potential (ERP) activity following auditory and visual stimuli. In the first experiment, EEG was recorded before and after the administration of a saline placebo or L657,743 (0.01, 0.05 mg/...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(93)90142-x

    authors: Pineda JA,Westerfield M

    更新日期:1993-01-01 00:00:00

  • Role of iNOS-NO-cGMP signaling in modulation of inflammatory and myelination processes.

    abstract::Nitric oxide (NO) is the main activator of the soluble guanylate cyclase (sGC)-guanosine 3'5' cyclic monophosphate (cGMP) pathway. The level of cGMP is regulated by phosphodiesterases (PDEs), which break down cGMP. It has been reported that levels of NO in the central nervous system (CNS) can greatly increase during d...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2014.04.002

    authors: Rapôso C,Luna RL,Nunes AK,Thomé R,Peixoto CA

    更新日期:2014-05-01 00:00:00

  • Effects of morphine on cortex, hippocampus and medial thalamus: a comparison between urethane-anaesthetized and paralyzed-awake rats.

    abstract::Urethane is often used as a central anaesthetic in neurophysiological studies of drug effects. In this experiment, the effect of morphine on cortical EEG and single units of hippocampus and medial thalamus were compared in urethane-anaesthetized and paralyzed-awake rats. In each case, there was evidence of a morphine-...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(80)90183-5

    authors: Linseman MA

    更新日期:1980-03-01 00:00:00

  • Localization of motoneurons innervating the levator veli palatini muscle in the cat.

    abstract::Recent investigations of the nucleus ambiguus (NA) have attempted to identify motoneurons associated with the branchiomeric muscles of the larynx and pharynx. However, relatively little attention has been directed to the levator veli palatini muscle (LVP) which is critical in respiration, deglutition and eustachian tu...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(83)90165-x

    authors: van Loveren H,Saunders MC,Keller JT

    更新日期:1983-09-01 00:00:00

  • FGF9 knockout in GABAergic neurons induces apoptosis and inflammation via the Fas/caspase-3 pathway in the cerebellum of mice.

    abstract::Fibroblast growth factor 9 (FGF9) is a member of the fibroblast growth factor family and is widely expressed in the central nervous system (CNS). However, it is not clear how the working mechanism of FGF9 is involved in cerebellar development. To address this question, we deleted the Fgf9 gene specifically in GABAergi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2019.10.012

    authors: Guo M,Chen H,Duan W,Li Z,Li Y,Ma Y,Xu X,Yi L,Bi Y,Liu Y,Zhang J,Li C

    更新日期:2020-01-01 00:00:00

  • Phenotypic characteristics of hybrid cells generated by transferring neuronal nuclei into bone marrow stromal cell cytoplasts.

    abstract::Bone marrow stromal cells (BMSCs) are promising donor cells for transplantation therapies for a variety of diseases. However, there still lack efficient ways to induce directional differentiation of BMSCs to promote their practical use in transplantation therapy. In this study, we constructed hybrid cells by transferr...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2011.11.001

    authors: Zhou Z,Xu Y,Zhong Q,Zheng J

    更新日期:2012-02-10 00:00:00

  • Valproic acid suppresses the synaptic response mediated by the NMDA receptors in rat amygdalar slices.

    abstract::The mechanism of action of the anticonvulsant drug valproic acid (VPA) was studied in rat amygdaloid slices using intracellular recording techniques. In the presence of bicuculline (20 microM), stimulation of the endopyriform nucleus evoked an excitatory postsynaptic potential (EPSP) followed by a paroxysmal depolariz...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(94)90202-x

    authors: Gean PW,Huang CC,Hung CR,Tsai JJ

    更新日期:1994-01-01 00:00:00

  • Altered conditioned taste aversion and glucose utilization in related brain nuclei of diabetic GK rats.

    abstract::The impact of diabetes and especially hyperglycemia on brain glucose utilization and insulin binding are still not clear. This is probably due to the fact that most studies have been performed in streptozotocin treated rats that are highly hyperglycemia and that could have an effect per se on the brain. The aim of the...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(95)00060-r

    authors: Marfaing-Jallat P,Portha B,Pénicaud L

    更新日期:1995-01-01 00:00:00

  • Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression.

    abstract::In this study, we compared the depression-like symptoms induced by olfactory bulbectomy (OBX) in the two inbred Wistar and Long Evans rat strains. We also analyzed the self-regulated oral intake of nicotine in these strains and the effect of nicotine on the depression-like symptoms of olfactory bulbectomy. Furthermore...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2008.05.007

    authors: Vieyra-Reyes P,Mineur YS,Picciotto MR,Túnez I,Vidaltamayo R,Drucker-Colín R

    更新日期:2008-09-05 00:00:00

  • Subthalamic local field potential oscillations during ongoing deep brain stimulation in Parkinson's disease.

    abstract::How deep brain stimulation (DBS) acts and how the brain responds to it remains unclear. To investigate the mechanisms involved, we analyzed changes in local field potentials from the subthalamic area (STN-LFPs) recorded through the deep brain macroelectrode during monopolar DBS of the subthalamic nucleus area (STN-DBS...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2008.01.023

    authors: Rossi L,Marceglia S,Foffani G,Cogiamanian F,Tamma F,Rampini P,Barbieri S,Bracchi F,Priori A

    更新日期:2008-07-30 00:00:00

  • Tryptophan increases extracellular serotonin in the lateral hypothalamus of food-deprived rats.

    abstract::Although it is well established that increases in tryptophan availability can increase brain serotonin synthesis, the effect of tryptophan loads on serotonin release is not as clear. We have used in vivo microdialysis in order to monitor extracellular serotonin in the lateral hypothalamus to examine this issue. Trypto...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(90)90174-x

    authors: Schwartz DH,Hernandez L,Hoebel BG

    更新日期:1990-12-01 00:00:00

  • IGF-1R stimulation alters microglial polarization via TLR4/NF-κB pathway after cerebral hemorrhage in mice.

    abstract::Intracerebral hemorrhage (ICH) is a common neurological disease, causing severe disability and even deaths. Stem cell transplantation has been increasingly used in stroke therapy, and neural stem cells (NSCs) are a good source for stem cell transplantation. However, the regulatory mechanism of NSCs remains unclear. In...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2020.08.026

    authors: Sun Z,Wu K,Gu L,Huang L,Zhuge Q,Yang S,Wang Z

    更新日期:2020-11-01 00:00:00

  • Excitation of hypothalamic paraventricular neurons by stimulation of the raphe nuclei.

    abstract::Extracellular recordings were made from 467 anti-dromically identified neurosecretory neurons and 148 non-neurosecretory neurons in the paraventricular nucleus of the hypothalamus of hemispherectomized cats under pentobarbital anesthesia. Stimulation of the dorsal, median, and pontine raphe nuclei excited 31%, 26%, an...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(92)90105-7

    authors: Kawano S,Osaka T,Kannan H,Yamashita H

    更新日期:1992-04-01 00:00:00

  • The effects of lithium chloride on the activity of the afferent nerve fibers from the abdominal visceral organs in the rat.

    abstract::The effect of lithium chloride on the activity of the afferent nerve fibers from the abdominal organs was studied in anesthetized rats. The administration of the lithium chloride solution (0.15 M) over the mesentery increased afferent discharge rate of the splanchnic and vagal gastric nerve. Injection of the same solu...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(94)90094-9

    authors: Niijima A,Yamamoto T

    更新日期:1994-01-01 00:00:00

  • Alterations in the behavior, cognitive function, and BDNF level in adult male rats following neonatal blockade of GABA-A receptors.

    abstract::Gamma-aminobutyric acid (GABA) is an important inhibitory neurotransmitter in the mature brain. At an early developmental period, it acts in an excitatory manner that influences many processes of proliferation, migration, and differentiation of the neurons. Previous evidence indicated that manipulation of the GABAergi...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2021.01.006

    authors: Naderipoor P,Amani M,Abedi A,Sakhaie N,Sadegzadeh F,Saadati H

    更新日期:2021-01-10 00:00:00

  • Investigations of origins of serotonergic projection to developing rat visual cortex: a combined retrograde tracing and immunohistochemical study.

    abstract::The present study investigated whether the raphe neurons which give rise to the transient serotonergic fibers in the visual cortex of neonatal rats persist or disappear as the rats mature. Three experiments were performed employing the WGA-apoHRP-Au retrograde transport technique in conjunction with 5-HT or WGA-HRP im...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/0361-9230(91)90044-k

    authors: Koh T,Nakazawa M,Kani K,Maeda T

    更新日期:1991-11-01 00:00:00

  • A new model of transient focal cerebral ischemia for inducing selective neuronal necrosis.

    abstract::Brief cerebral ischemia leads to selective neuronal necrosis (SNN), which is characterized by neuronal death with sparing of glial and vascular elements of the central nervous system. Understanding the pathophysiology of SNN may help elucidating the mechanisms and consequences of neuronal injury in humans following br...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2008.11.005

    authors: Arsava EM,Gurer G,Gursoy-Ozdemir Y,Karatas H,Dalkara T

    更新日期:2009-03-16 00:00:00

  • Suppression of excitotoxicity and foreign body response by memantine in chronic cannula implantation into the rat brain.

    abstract::Chronic brain implants are accompanied by a tissue response that causes the loss of neurons in the vicinity of the implant and the formation of a glial scar that is also referred to as foreign body response. Despite immense progress in the field of brain-computer interface (BCI) research the biocompatibility of chroni...

    journal_title:Brain research bulletin

    pub_type: 杂志文章

    doi:10.1016/j.brainresbull.2015.08.001

    authors: Hayn L,Koch M

    更新日期:2015-08-01 00:00:00

  • Metabolic Dysfunction in Parkinson's Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism.

    abstract::The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson's disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging. However, the exact molecular mechani...

    journal_title:Brain research bulletin

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainresbull.2017.03.009

    authors: Anandhan A,Jacome MS,Lei S,Hernandez-Franco P,Pappa A,Panayiotidis MI,Powers R,Franco R

    更新日期:2017-07-01 00:00:00

  • Medicine and science in the life of Luigi Galvani (1737-1798).

    abstract::Together with its companion paper, dealing with the contribution of Luigi Galvani to the history of electrophysiology, this article provides a biographical sketch of the scientist of Bologna in the occasion of the bicentenary of his death. Studies on Galvani have focused mainly on his "discovery" of animal electricity...

    journal_title:Brain research bulletin

    pub_type: 传,历史文章,杂志文章

    doi:10.1016/s0361-9230(98)00023-9

    authors: Bresadola M

    更新日期:1998-07-15 00:00:00