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Medial versus lateral parabrachial nucleus lesions in the rat: effects on mercaptoacetate-induced feeding and conditioned taste aversion.

Abstract：

:The two experiments of the present study examined the influence of bilateral electrophysiologically-guided ibotenic acid lesions of the medial (gustatory) and lateral (viscerosensory) subdivisions of the parabrachial nucleus (PBN) on lipoprivic feeding and on the acquisition of a conditioned taste aversion. In Experiment 1, mercaptoacetate (0, 400, 600, or 800 micromol/kg) failed to enhance food intake in normal rats maintained and tested on standard laboratory chow. In the same procedure, rats with lesions of the medial or lateral PBN consumed less food during baseline but nonetheless were sensitive to the orexigenic action of mercaptoacetate. In Experiment 2, both types of PBN lesions prevented acquisition of a conditioned taste aversion induced by the oral self administration of lithium chloride. The results suggest that PBN neurons essential for conditioned taste aversion are not involved in the mercaptoacetate-induced feeding of rats maintained and tested on standard laboratory chow.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Trifunovic R,Reilly S

doi

10.1016/s0361-9230(02)00766-9

keywords:

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

107-13

issue

1

eissn

0361-9230

issn

1873-2747

pii

S0361923002007669

journal_volume

58

pub_type

杂志文章

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