Pineal modulation of ACTH 1-17 effect upon murine corticosterone production.

Abstract:

:In tests of corticosterone production in vitro, aqueous pineal homogenate (APH) modulates the effect of a short-chain ACTH analogue, ACTH 1-17, added to adrenals from different circadian stages. Adrenal and pineal glands from female B6D2F1 mice, standardized on staggered LD 12:12 regimens, were obtained at the same clock-hour from each room, in order to cover 6 different circadian stages. Adrenals from each circadian stage were bisected and incubated with APH from the same circadian stage (isophasic incubation) or from one of the other 5 circadian stages (heterophasic incubation). ACTH 1-17 (0.05 IU) was added to each incubation medium. After 4 hours of incubation at 37 degrees C with 95% O2 and 5% CO2, the media were stored at -20 degrees C until corticosterone RIA were done. APH was found to have a statistically significant modulatory effect upon the stimulation by ACTH 1-17 of adrenal corticosterone production in vitro. This APH effect changed rhythmically as a function of circadian stage from amplification over no effect to attenuation, as a so-called feed-sideward.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Sánchez de la Peña S,Halberg F,Halberg E,Ungar F,Cornelissen G,Sánchez E,Brown G,Scheving LE,Yunis EG,Vecsei P

doi

10.1016/0361-9230(83)90060-6

subject

Has Abstract

pub_date

1983-07-01 00:00:00

pages

117-25

issue

1

eissn

0361-9230

issn

1873-2747

pii

0361-9230(83)90060-6

journal_volume

11

pub_type

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