Persistence of dihydrotestosterone inhibition of lordosis in estrogen-primed rats fed a tryptophan-deficient diet.

Abstract:

:Administering increasing dosages of 5alpha-dihydrotestosterone propionate (DHTP) (0, 40, or 80 microgram/100 g in oil daily) to ovariectomized female rats treated concurrently with estradiol benzoate (EB) (1 microgram/100 g in oil daily) caused significant, equivalent reduction in lordotic responsiveness in rats maintained either on a tryptophan-deficient corn diet or on a corn diet to which L-tryptophan was added. Whole brain concentrations of 5-hydroxytryptamine (5-HT) and of 5-hydroxyindoleacetic acid were approximately two times higher in rats fed corn+tryptophan versus corn alone. These findings suggest that the ability of DHTP to inhibit lordosis probably depends upon some mechanism other than a facilitation of 5HT release from serotonergic neurons.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Menniti FS,Erskine MS,Baum MJ

doi

10.1016/0361-9230(81)90090-3

subject

Has Abstract

pub_date

1981-07-01 00:00:00

pages

1-4

issue

1

eissn

0361-9230

issn

1873-2747

pii

0361-9230(81)90090-3

journal_volume

7

pub_type

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