The maintenance of individual differences in the sensitivity of acute and neuropathic pain behaviors to electroacupuncture in rats.

Abstract:

:"Responder" Sprague-Dawley (SD) rats that were sensitive to electroacupuncture (EA) in an acute thermal pain test (i.e. tail flick latency [TFL] test) maintained sensitivity to EA in the warm allodynia test after peripheral nerve injury. Similarly, the "non-responder" SD rats that were insensitive to EA in the TFL test were also insensitive to EA in the allodynia test. The EA-induced analgesic effects in the TFL test were significantly higher in CCK-A receptor deficient, Otsuka Long-Evans Tokushima Fatty (OLETF) rats than in their littermates, Long-Evans Tokushima Otsuka (LETO) rats. Similarly, the anti-allodynic effects of EA were significantly greater in OLETF rats than in LETO rats. These results suggest that the individual differences in the sensitivity of acute pain behavior to EA were maintained in neuropathic pain behavior following peripheral nerve injury, and that CCK-A receptor expression plays an important role in mediating this phenomenon.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Kim SK,Moon HJ,Park JH,Lee G,Shin MK,Hong MC,Bae H,Jin YH,Min BI

doi

10.1016/j.brainresbull.2007.07.006

subject

Has Abstract

pub_date

2007-10-19 00:00:00

pages

357-60

issue

5

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(07)00214-6

journal_volume

74

pub_type

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