Abstract：
:Cocaine is a major stimulant drug which can have rewarding and locomotor activating effects. It is used by non-addicts to enhance concentration and performance in a work or social setting. It was suggested that cocaine may amplify the impact of mood and sensory stimulation on behaviour. Here we tested whether cocaine can enhance the impact of novel sensory stimulation on exploratory locomotor activity. In this study the effects of cocaine (0, 2.5, 5.0, 10mg/kg, i.p.) on the locomotor response induced by on-off light stimulation with different light intensities (0, 22, 83, 440 lx) was investigated. Visual stimulation increased locomotor activity and grooming behaviour. Cocaine more dramatically increased locomotion and rearing behaviour but suppressed grooming. Also, visual stimulation effects on grooming were reduced by cocaine. The additive relationship between the cocaine and visual stimulation effects on locomotion and rearing combined with their opposing impact upon grooming point to independent mechanisms mediating cocaine- and visual stimulation-induced behavioural activation.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Pum ME,Rubio AR,Carey RJ,Silva MA,Müller CPdoi
10.1016/j.brainresbull.2010.12.015subject
Has Abstractpub_date
2011-02-28 00:00:00pages
229-34issue
3eissn
0361-9230issn
1873-2747pii
S0361-9230(11)00003-7journal_volume
84pub_type
杂志文章abstract：:Gonadotropin-releasing hormone (GnRH) is the neuropeptide that links the brain to the reproductive system. Most vertebrate species express two forms of GnRH, which differ in amino acid sequence, localization, distribution, and embryological origin. The GnRH system in the ventral forebrain produces a species-specific G...
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.brainresbull.2007.10.031
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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更新日期：2001-03-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(90)90257-z
更新日期：1990-07-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2012.02.011
更新日期：2012-04-10 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(97)00118-4
更新日期：1997-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(94)90062-0
更新日期：1994-01-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/j.brainresbull.2009.11.008
更新日期：2010-03-16 00:00:00
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pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2008-03-18 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2000-09-15 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2000-05-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
doi：10.1016/j.brainresbull.2008.12.002
更新日期：2009-03-30 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(84)90209-0
更新日期：1984-01-01 00:00:00
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journal_title：Brain research bulletin
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更新日期：2021-01-07 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：2006-07-31 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/s0361-9230(00)00353-1
更新日期：2000-10-01 00:00:00
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journal_title：Brain research bulletin
pub_type： 杂志文章,评审
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更新日期：2019-08-01 00:00:00
abstract：:Adenoviral vector directed gene transfer to rat facial motoneurons occurs efficiently following intra-parenchymal injection of relatively high dosages (> or =10(7) pfu per injection) of a prototype first generation adenoviral vector. However, high level of transgene expression, as observed during the first week follow...
journal_title：Brain research bulletin
pub_type： 杂志文章
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更新日期：1998-09-15 00:00:00
