Fenfluramine binds 5-hydroxytryptophan.

abstract：:In order to test the functional significance of noradrenergic neurotransmission for brain maturation, rat pups were injected daily with clonidine from 8-21 days of postnatal life. In adulthood, single cell responses to microiontophoretically applied neurotransmitters were studied in different layers of the hippocampus...

journal_title：Brain research bulletin

authors： Gorter JA,Mirmiran M,Bos NP,Van der Werf D

更新日期：1989-10-01 00:00:00

abstract：:The morphological interactions between astroglial and neuronal elements were elucidated in the rat suprachiasmatic nucleus (SCN) by light and electron microscopic immunocytochemistry using antibodies against glial fibrillary acidic protein (GFAP), vasoactive intestinal peptide (VIP) and arginine-vasopressin (AVP). Thr...

journal_title：Brain research bulletin

authors： Tamada Y,Tanaka M,Munekawa K,Hayashi S,Okamura H,Kubo T,Hisa Y,Ibata Y

更新日期：1998-01-01 00:00:00

abstract：:Endocannabinoid system activity contributes to the homeostatic defense against aging and thus may counteract the progression of brain aging. The cannabinoid type 1 (CB1) receptor activity declines with aging in the brain, which impairs neuronal network integrity and cognitive functions. However, the underlying mechani...

journal_title：Brain research bulletin

authors： Kataoka K,Bilkei-Gorzo A,Nozaki C,Togo A,Nakamura K,Ohta K,Zimmer A,Asahi T

更新日期：2020-07-01 00:00:00

abstract：:The purinergic signaling system, including P2 receptors, plays an important role in various central nervous system (CNS) disorders. Over the last few decades, a substantial amount of accumulated data suggest that most P2 receptor subtypes (P2X1, 2, 3, 4, 6, and 7, and P2Y1, 2, 6, 12, and 13) regulate neuronal/neurogli...

journal_title：Brain research bulletin

authors： Huang L,Otrokocsi L,Sperlágh B

更新日期：2019-09-01 00:00:00

abstract：:The most severe manifestation of Herpes Simplex Type 1 virus (HSV-1) infection is encephalitis characterized by arousal impairment and seizures that can evolve to coma and death. Previous studies reported the involvement of suppressor of cytokine signaling (SOCS) proteins, specifically SOCS1 and SOCS3, in HSV-1 infect...

journal_title：Brain research bulletin

authors： da Cunha Sousa LF,Rachid MA,Lima GK,de Miranda AS,de Carvalho Vilela M,Lacerda Queiroz N,Rodrigues DH,Campos MA,Kroon EG,Machado FS,Teixeira AL

更新日期：2016-10-01 00:00:00

abstract：:Until now, economic theory has not systematically integrated the influence of emotions on decision-making. Since evidence from neuroscience suggests that decision-making as hypothesized in economic theory depends on prior emotional processing, interdisciplinary research under the label of "neuroeconomics" arose. The k...

journal_title：Brain research bulletin

authors： Kenning P,Plassmann H

更新日期：2005-11-15 00:00:00

abstract：:Electroretinographic evoked potentials (ERGs) were recorded in dark adapted crayfish by the application of pulses of light (0.09 Cd/ft2) presented every 2.5 min. Heterolateral illumination (HI) for sixty min (0.06-0.3 Cd/ft2) induced up to 50% decrease in ERG after a latency of 12-25 min. ERG depression was proportion...

journal_title：Brain research bulletin

authors： Barrera-Mera B,Abasta EM

更新日期：1978-03-01 00:00:00

abstract：:Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect, yet the role of the insulin receptor in mediating depression is not clearly established because insulin receptors are not required for glucose entry into the brain. However, insulin receptors are important for brain function...

journal_title：Brain research bulletin

authors： Mueller PL,Pritchett CE,Wiechman TN,Zharikov A,Hajnal A

更新日期：2018-10-01 00:00:00

abstract：:Axons of retinal ganglion cells showed responses not previously emphasized: (a) many tonic units discharged oscillations, 2--12 spikes per burst, interburst intervals 20--300 msec; (b) phasic units showed concentric or flanking ON and OFF fields, response frequency depended on balance of retinal excitation and inhibit...

journal_title：Brain research bulletin

authors： O'Benar JD

更新日期：1976-11-01 00:00:00

abstract：:Gamma-secretase (GS) is an enzyme complex that cleaves numerous substrates, and it is best known for cleaving amyloid precursor protein (APP) to form amyloid-beta (Aβ) peptides. Aberrant cleavage of APP can lead to Alzheimer's disease, so much research has been done to better understand GS structure and function in ho...

journal_title：Brain research bulletin

authors： Carroll CM,Li YM

更新日期：2016-09-01 00:00:00

abstract：:Prey-catching behavior (PCB) of the frog consists of a sequence of coordinated activity of muscles which is modified by various sensory signals. The aim of the present study was, for the first time, to examine the involvement of the trigeminal afferents in the swallowing phase of PCB. Experiments were performed on Ran...

journal_title：Brain research bulletin

authors： Kecskes S,Matesz C,Birinyi A

更新日期：2013-10-01 00:00:00

abstract：:Neurochemical and morphological effects of neonatal anoxia on monoamine systems were studied after 100% N2 exposure for 25 min at 30 h postnatally (postnatal day 2-P2). At 20 min after anoxia, reductions of tissue levels of cerebellar noradrenaline (NA) and striatal dopamine (DA) and metabolites were seen, while 5-hyd...

journal_title：Brain research bulletin

authors： Dell'Anna ME,Luthman J,Lindqvist E,Olson L

更新日期：1993-01-01 00:00:00

abstract：:The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 18...

journal_title：Brain research bulletin

authors： Norgren RB Jr,McLean JH,Bubel HC,Wander A,Bernstein DI,Lehman MN

更新日期：1992-03-01 00:00:00

abstract：:The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition in...

journal_title：Brain research bulletin

authors： Kakinoki H,Ishizawa K,Fukunaga M,Fujii Y,Kamei C

更新日期：1998-07-15 00:00:00

abstract：:Although originally developed as a research tool for studying glial-glial and glial-axonal interactions, the technique of transplanting glial cell into the central nervous system has more recently been employed as a potential means for repairing persistent demyelination in clinical disease. It has now been clearly est...

journal_title：Brain research bulletin

authors： Franklin RJ

更新日期：2002-04-01 00:00:00

abstract：:Spinocerebellar ataxia type 2 is caused by a polyglutamine stretch in the protein ataxin-2 that is due to an expansion of a CAG repeat in the spinocerebellar ataxia-2 gene. The function of wild-type ataxin-2 has not been clarified. A widespread distribution of this protein throughout the brain has been reported. We ex...

journal_title：Brain research bulletin

authors： Fusco FR,Viscomi MT,Bernardi G,Molinari M

更新日期：2001-10-01 00:00:00

abstract：:Norepinephrine (NE) and dopamine (DA) levels and turnover were measured in 17 discrete brain regions of Swiss-Webster (NIH) mice made aggressive by prolonged isolation. The NE steady state level was significantly lower in olfactory tubercle and substantia nigra and significantly higher in the septal area of the aggres...

journal_title：Brain research bulletin

authors： Tizabi Y,Massari VJ,Jacobowitz DM

更新日期：1980-01-01 00:00:00

abstract：:The non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist dizocilpine (MK-801) attenuates morphine-induced immediate-early gene expression in the rat striatum in a sexually dimorphic manner that depends in part on gonadal steroids. To determine if this effect was dependent on modulation of glutamate receptor...

journal_title：Brain research bulletin

authors： D'Souza DN,Harlan RE,Garcia MM

更新日期：2003-01-15 00:00:00

abstract：:During normal ageing, photoreceptors of the human retina undergo various structural changes. We examined retinas from 33 donors (56 eyes; age span 13-94 years) by electron microscopy to see morphological changes in the cones with ageing. We show mitochondrial alterations and occurrence of electron-dense globules in th...

journal_title：Brain research bulletin

authors： Nag TC,Wadhwa S,Chaudhury S

更新日期：2006-12-11 00:00:00

abstract：:Space motion sickness (SMS) and spatial orientation and motion perception disturbances occur in 70-80% of astronauts. People select "rest frames" to create the subjective sense of spatial orientation. In microgravity, the astronaut's rest frame may be based on visual scene polarity cues and on the internal head and bo...

journal_title：Brain research bulletin

authors： Harm DL,Parker DE,Reschke MF,Skinner NC

更新日期：1998-11-15 00:00:00

abstract：:Extracellular recordings were made from 467 anti-dromically identified neurosecretory neurons and 148 non-neurosecretory neurons in the paraventricular nucleus of the hypothalamus of hemispherectomized cats under pentobarbital anesthesia. Stimulation of the dorsal, median, and pontine raphe nuclei excited 31%, 26%, an...

journal_title：Brain research bulletin

authors： Kawano S,Osaka T,Kannan H,Yamashita H

更新日期：1992-04-01 00:00:00

abstract：:Recent in vivo electrophysiological studies in our laboratory demonstrated medial thalamus (MT) induced short-term facilitation in the middle layers of the anterior cingulate cortex (ACC). The aim of the present study was to investigate different forms of short-term plasticity (STP) in layer II/III of the ACC in an in...

journal_title：Brain research bulletin

authors： Lee CM,Sylantyev S,Shyu BC

更新日期：2007-01-09 00:00:00

abstract：:Electrophysiological responses to olfactory and gustatory stimuli were recorded in the same neural elements in the parabrachial nuclei (PbN) of rats under Flaxedil. Responses to olfactory stimuli varied in temporal pattern and magnitude from responses to gustatory stimuli. Intravenous infusion of Nembutal while record...

journal_title：Brain research bulletin

authors： Di Lorenzo PM,Garcia J

更新日期：1985-12-01 00:00:00

abstract：:Aβ plaques of Alzheimer's disease (AD) are believed to precede cognitive deficits or clinical manifestation by decades. However, validated biomarkers for early diagnosis of the AD disease are still not available. In this present study, we combined MRI-based neuroimages and histological assessment of the glial response...

journal_title：Brain research bulletin

authors： Liu L,Liu Y,Li N,Huang R,Zheng X,Huang L,Hou S,Yuan Q

更新日期：2020-03-01 00:00:00

abstract：:Ouabain, tetrodotoxin, and calcium selective ionophore (A23187) were administered bilaterally into the hypothalamus of the unrestrained, fully conscious cat, while body temperature and other indicators of thermoregulatory responses were monitored continuously. Posterior hypothalamic microinjection of 2.0 to 10.0 ng or...

journal_title：Brain research bulletin

authors： Jones DL,Veale WL,Cooper KE

更新日期：1980-01-01 00:00:00

abstract：:The vertebrate neural tube consists of a series of neuromeres along its anteroposterior axis. Between amphioxus that possesses no neuromeres and gnathostomes, the lamprey occupies a critical position in the phylogeny for the origin of the segmented brain. To clarify the rhombomeric configuration of the Japanese lampre...

journal_title：Brain research bulletin

authors： Murakami Y,Ogasawara M,Satoh N,Sugahara F,Myojin M,Hirano S,Kuratani S

更新日期：2002-02-01 00:00:00

abstract：:Adenoviral vector directed gene transfer to rat facial motoneurons occurs efficiently following intra-parenchymal injection of relatively high dosages (> or =10(7) pfu per injection) of a prototype first generation adenoviral vector. However, high level of transgene expression, as observed during the first week follow...

journal_title：Brain research bulletin

authors： Hermens WT,Verhaagen J

更新日期：1998-09-15 00:00:00

abstract：:Brief cerebral ischemia leads to selective neuronal necrosis (SNN), which is characterized by neuronal death with sparing of glial and vascular elements of the central nervous system. Understanding the pathophysiology of SNN may help elucidating the mechanisms and consequences of neuronal injury in humans following br...

journal_title：Brain research bulletin

authors： Arsava EM,Gurer G,Gursoy-Ozdemir Y,Karatas H,Dalkara T

更新日期：2009-03-16 00:00:00

abstract：PURPOSE:We assessed the potential of resting-state fMRI lag analysis (RSLA) in detecting epileptic activation and in estimating anti-epileptic effects of Levetiracetam (LEV) in Rolandic epilepsy. METHODS:Forty-three children with Rolandic epilepsy underwent simultaneous EEG-fMRI. They were grouped into LEV vs drug-naï...

journal_title：Brain research bulletin

authors： Xu Q,Hu Z,Yang F,Bernhardt BC,Zhang Q,Stufflebeaskm SM,Zhang Z,Lu G

更新日期：2020-09-01 00:00:00

abstract：:Here we asked if insulin activation of the nucleus accumbens in vitro is reflected by an increase in (3)H-deoxyglucose ([(3)H]DG) uptake, thus subserving a new model to study molecular mechanisms of central insulin actions. Additionally, we investigated the dependence of this insulin effect on endocannabinoids and cor...

journal_title：Brain research bulletin

authors： Pinheiro BS,Lemos C,Neutzling Kaufmann F,Marques JM,da Silva-Santos CS,Carvalho E,Mackie K,Rodrigues RJ,Cunha RA,Köfalvi A

更新日期：2016-06-01 00:00:00