Anterograde transport of HSV-1 and HSV-2 in the visual system.

Abstract:

:The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Norgren RB Jr,McLean JH,Bubel HC,Wander A,Bernstein DI,Lehman MN

doi

10.1016/0361-9230(92)90038-y

keywords:

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

393-9

issue

3

eissn

0361-9230

issn

1873-2747

pii

0361-9230(92)90038-Y

journal_volume

28

pub_type

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