Abstract:
:The anterograde spread of herpesvirus in the visual system subsequent to retinitis has been observed clinically. We compared the ability of two well-studied Herpes simplex virus (HSV) strains to be transported in the anterograde direction in the hamster visual system: strain McIntyre, representing HSV-1, and strain 186, representing HSV-2. Intravitreal injection of HSV-2 labeled more retinorecipient neurons than did HSV-1, suggesting important type differences in the ability of HSV to infect retinorecipient neurons after intravitreal injection. The most likely explanation for our results is that HSV-2 is more efficiently adsorbed than HSV-1 in the retinal ganglion cells. Our results also suggest that HSV may be useful as an anterograde transneuronal tracer for neuroanatomical studies of the visual system.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Norgren RB Jr,McLean JH,Bubel HC,Wander A,Bernstein DI,Lehman MNdoi
10.1016/0361-9230(92)90038-ykeywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
393-9issue
3eissn
0361-9230issn
1873-2747pii
0361-9230(92)90038-Yjournal_volume
28pub_type
杂志文章abstract::The effects of two diketopiperazines, Cyclo (His-Pro) (CHP) and Cyclo (Asp-Phe) (CAP), on striatal extracellular levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) were examined using in vivo microdialysis in anaesthetized rats. Treatment with ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(93)90171-7
更新日期:1993-01-01 00:00:00
abstract::Thyroid-stimulating hormone (TSH) stimulates the synthesis and release of thyroid hormones including triiodothyronine (T3) and thyroxine (T4). Semiquantitative analyses using northern blot and in situ hybridization suggested that TSH gene transcription is upregulated under conditions of hypothyroidism. However, no qua...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.06.004
更新日期:2007-09-14 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2016.05.010
更新日期:2016-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(89)90193-7
更新日期:1989-12-01 00:00:00
abstract::Although increasing evidence indicates that psychiatric symptoms are crucial characteristic of the early stage of Parkinson's disease (PD) and precede motor impairments, the neuronal firing activity of the basolateral nucleus of the amygdala (BLA) in the psychiatric symptom of PD and the involved mechanism are still u...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2011.05.009
更新日期:2011-07-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(95)02117-5
更新日期:1996-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00460-3
更新日期:2001-03-01 00:00:00
abstract::Horseradish peroxidase (HRP, Sigma Type VI) crystals were encased in a parafilm envelope and applied to the transected central ends of the left and right cervical vagus nerves and the anterior and posterior esophageal vagus nerves of adult male hooded rats. Injections of 30% HRP were made into the muscle wall of the f...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(84)90040-6
更新日期:1984-10-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2016.06.010
更新日期:2016-06-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2008.02.004
更新日期:2008-06-15 00:00:00
abstract::Developing animals are more sensitive than adults to the delayed neurotoxicity caused by chlorpyrifos exposure. In developing rat brain, chlorpyrifos doses that cause no discernible systemic toxicity and only a minor degree of cholinesterase inhibition, nevertheless evoke alterations in cell function and number that a...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(97)00329-8
更新日期:1998-01-01 00:00:00
abstract::We previously reported that systemic treatment with a noncompetitive antagonist affecting the NMDA subtype of excitatory amino acid (EAA) receptor, MK-801, inhibits photic induction of Fos-like immunoreactivity (Fos-lir) in the hamster suprachiasmatic nucleus (SCN). Because MK-801 blocks the Ca2+ channel associated wi...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90269-4
更新日期:1992-05-01 00:00:00
abstract::Cell-free incorporation of (14C) leucine into protein was 38% greater for cerebral cortical microsomes from 22-day old neonatally thyroidectomized rats compared to littermate controls. In contrast, incorporation by liver microsomes of hypothyroid rats was 33% lower compared to controls, confirming their deficient horm...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(80)90275-0
更新日期:1980-01-01 00:00:00
abstract::The lateral hypothalamic area (LHA) and globus pallidus (GP) are basically involved in the regulation of feeding and metabolic processes. In the LHA, glucose-sensitive (GS) neurons were described: their activity was found to be specifically suppressed by electrophoretic application of glucose, and these neurons appear...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(94)00269-7
更新日期:1995-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(92)90020-x
更新日期:1992-08-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(97)00403-6
更新日期:1998-01-01 00:00:00
abstract::The periventricular tissue surrounding the anteroventral third ventricle (AV3V) is critically involved in the maintenance of normal body fluid balance and distribution. The present review examines the anatomical, neurochemical, and functional relationship of the AV3V with neural systems subserving body fluid homeostas...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/0361-9230(85)90209-6
更新日期:1985-12-01 00:00:00
abstract::Among the brain areas studied only pars distalis and pars intermedia are found to contain beta-lipotropin activating enzyme indicating the these may be the exclusive organs for a physiologically significant conversion of beta-lipotropin into beta-endorphin. beta-Endorphin inactivating enzyme is found to be rather unif...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(77)90079-x
更新日期:1977-07-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00337-3
更新日期:2000-09-15 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(82)90067-3
更新日期:1982-03-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(00)00362-2
更新日期:2000-12-01 00:00:00
abstract::The olfactory bulbectomized (OBX) rat model of depression has been widely used in studies on the behavioral and neurochemical aspects of human depression. The objective of the present investigation was to assess open field (OF) activity and the brain regional 5-HT(1A) receptor densities of the sham operated (SHX) and ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2007.09.005
更新日期:2008-03-28 00:00:00
abstract::Current treatments for Parkinson's disease (PD) rely on a dopamine replacement strategy and are reasonably effective, particularly in the early stages of the disease. However, chronic dopaminergic therapy is limited by the development of a range of side effects, including dyskinesia. This has led to a search for alter...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2004.10.011
更新日期:2005-12-15 00:00:00
abstract::The possible existence of two separate RSA generators in the dorsal hippocampus raises questions as to the degree of coupling or independence of both. In order to answer these questions bipolar EEG recording were made in the CA1 and dentate gyrus of freely moving rats during conditions of RSA generation by different m...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/s0361-9230(81)80063-9
更新日期:1981-01-01 00:00:00
abstract::Prey-catching behavior (PCB) of the frog consists of a sequence of coordinated activity of muscles which is modified by various sensory signals. The aim of the present study was, for the first time, to examine the involvement of the trigeminal afferents in the swallowing phase of PCB. Experiments were performed on Ran...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2013.09.006
更新日期:2013-10-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a degenerative disease with a progressive loss of motor neurons in the central nervous system (CNS). However, there are unsolved problems with the therapies for this disease. α-Lipoic acid (LA) is a natural, universal antioxidant capable of scavenging hydroxyl radicals as well as...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2018.05.019
更新日期:2018-06-01 00:00:00
abstract::Stroke is one of the leading causes of mortality and morbidity worldwide. Due to its poor prognosis, there is a major negative impact on the patients and their family's life quality. However, despite the severity of this pathology tissue plasminogen activator (tPA) is the only FDA approved treatment for ischemic strok...
journal_title:Brain research bulletin
pub_type: 杂志文章,评审
doi:10.1016/j.brainresbull.2019.07.015
更新日期:2019-10-01 00:00:00
abstract::The contribution deals with the distribution of alkaline phosphatase and 5-nucleotidase in the medulla oblongata of Taphozous melanopogon (a Microchiroptera), for the first time. The main highlights of the study are: (1) Cranial nerve nuclei demonstrate intense activity of alkaline phosphatase, whereas except nucleus ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(79)90030-3
更新日期:1979-07-01 00:00:00
abstract::Following main olfactory bulb (MOB) stimulation at frequencies of 0.1-0.3 Hz, in addition to early field potentials, a frequency-sensitive, surface negative late N2 wave (latency range: 63-96 msec) followed occasionally by a late N3 transient, was evoked in the piriform cortex and endopiriform nucleus of the rat. The ...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/0361-9230(88)90133-5
更新日期:1988-04-01 00:00:00
abstract::The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates the tachykinin NK1 receptor, but with binding site and signaling pathways different from Substance P (SP). NK1 receptor is involved in nociception, but our earlier data showed that it has no role in chronic neuropathic hyperalges...
journal_title:Brain research bulletin
pub_type: 杂志文章
doi:10.1016/j.brainresbull.2019.01.015
更新日期:2019-04-01 00:00:00