Abstract：
:Stroke is one of the leading causes of mortality and morbidity worldwide. Due to its poor prognosis, there is a major negative impact on the patients and their family's life quality. However, despite the severity of this pathology tissue plasminogen activator (tPA) is the only FDA approved treatment for ischemic stroke. Moreover, there is no effective treatment for hemorrhagic stroke and only some palliative procedures are often performed to improve the patient's quality of life. Considering this, nanotechnology can offer some advantages for the development of new therapies for stroke. Among the various types of nanomaterials, liposomes are the most extensively studied due to their biocompatibility, biodegradability, and low toxicity. Liposomes, as a drug delivery system, are able to mask therapeutic compounds and allow their passage through the blood-brain barrier. Liposomes also protect drugs from degradation in a biological environment, increasing the circulation time and accumulation in the target tissue. Hence, this review highlights the potential of liposomes applications for delivery of therapeutic compounds for treating stroke.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Bruch GE,Fernandes LF,Bassi BLT,Alves MTR,Pereira IO,Frézard F,Massensini ARdoi
10.1016/j.brainresbull.2019.07.015subject
Has Abstractpub_date
2019-10-01 00:00:00pages
246-256eissn
0361-9230issn
1873-2747pii
S0361-9230(19)30011-5journal_volume
152pub_type
杂志文章,评审abstract：:A method is described for the isolation and culture of neurons in the adult mammalian brain. The cell could be maintained in primary culture for more than several weeks. Whereas the neurons freshly dissociated from the adult brain did not respond to any of the neurotransmitter substances applied, the neurons regained ...
journal_title：Brain research bulletin
pub_type： 杂志文章
doi：10.1016/0361-9230(91)90058-r
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pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Brain research bulletin
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2020-05-01 00:00:00
