Liposomes for drug delivery in stroke.

Abstract:

:Stroke is one of the leading causes of mortality and morbidity worldwide. Due to its poor prognosis, there is a major negative impact on the patients and their family's life quality. However, despite the severity of this pathology tissue plasminogen activator (tPA) is the only FDA approved treatment for ischemic stroke. Moreover, there is no effective treatment for hemorrhagic stroke and only some palliative procedures are often performed to improve the patient's quality of life. Considering this, nanotechnology can offer some advantages for the development of new therapies for stroke. Among the various types of nanomaterials, liposomes are the most extensively studied due to their biocompatibility, biodegradability, and low toxicity. Liposomes, as a drug delivery system, are able to mask therapeutic compounds and allow their passage through the blood-brain barrier. Liposomes also protect drugs from degradation in a biological environment, increasing the circulation time and accumulation in the target tissue. Hence, this review highlights the potential of liposomes applications for delivery of therapeutic compounds for treating stroke.

journal_name

Brain Res Bull

journal_title

Brain research bulletin

authors

Bruch GE,Fernandes LF,Bassi BLT,Alves MTR,Pereira IO,Frézard F,Massensini AR

doi

10.1016/j.brainresbull.2019.07.015

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

246-256

eissn

0361-9230

issn

1873-2747

pii

S0361-9230(19)30011-5

journal_volume

152

pub_type

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