Abstract:
:A newly developed technique employing the retrograde transport of horseradish peroxidase combined with immunocytochemistry is used to identify the cells of origin of descending spinal pathways and their putative neurotransmitters. With this technique the brainstem origins of descending serotonergic (5HT) pathways to the lumbar spinal cord have been determined in the monkey. Numerous 5HT stained neurons are found in the nucleus raphe obscurus and raphe magnus and in the adjacent reticular formation projecting to the lumbar spinal cord. The nucleus raphe pallidus contains relatively fewer descending 5HT neurons. In addition to the spinally projecting neurons containing 5HT, large multipolar shaped neurons within the raphe nuclei were found to project to the spinal cord, but these do not stain for 5HT immunoreactivity. These findings indicate that the raphe nuclear complex provides both serotonergic and non-serotonergic inputs to the spinal cord. The advantages and uses of the present double labeling method for localizing other neurotransmitter substances in identified neuronal pathways are discussed.
journal_name
Brain Res Bulljournal_title
Brain research bulletinauthors
Bowker RM,Westlund KN,Coulter JDdoi
10.1016/0361-9230(82)90140-xsubject
Has Abstractpub_date
1982-07-01 00:00:00pages
271-8issue
1-6eissn
0361-9230issn
1873-2747pii
0361-9230(82)90140-Xjournal_volume
9pub_type
杂志文章abstract::Autoradiography was employed to investigate the efferent projections from the lateral hypothalamus in the guinea pig. Lateral hypothalamic axons were traced along the medial forebrain bundle in both ascending and descending directions. Anteriorly, the label was traced along the medial forebrain bundle in both ascendin...
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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journal_title:Brain research bulletin
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更新日期:2008-12-16 00:00:00
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journal_title:Brain research bulletin
pub_type: 杂志文章
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pub_type: 杂志文章
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